Patient Oriented Research in Clinical Nutrition

以患者为中心的临床营养研究

基本信息

批准号：
7185258
负责人：
Thomas R Ziegler
金额：
$ 16.12万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7185258
关键词：
3-nitrotyrosine Abdomen Academic Medical Centers Acetaminophen Acute Adipose tissue Adult Advisory Committees Affect Alabama Alberta province Allogeneic Bone Marrow Transplantation American American Medical Association Amino Acids Anabolic Agents Animal Experiments Animal Model Animals Apoptosis Appendix Applications Grants Area Arts Attenuated Autologous Bone Marrow Transplantation Award Awareness Bacterial Toxins Basic Science Belief Biochemistry Biography Biological Assay Biological Markers Biopsy Biopsy Specimen Biotechnology Blood Blood Vessels Blood specimen Body Weight decreased Bone Marrow Transplantation Book Chapters Boston Burn Trauma Burn injury C-reactive protein Caco-2 Cells Canada Cardiac Caring Cell Line Cell Proliferation Cell model Cell physiology Cells Centers for Disease Control and Prevention (U.S.)Chairperson Chemicals Child Child health care Childhood China Chronic Chronic Kidney Failure Class Clinic Clinical Clinical Endocrinology Clinical Investigator Clinical Investigator Award Clinical Nutrition Clinical Research Clinical Trials Clinical and Translational Science Awards Clinical assessments Cobalamin Collaborations Commit Committee Members Communicable Diseases Communities Complex Consult Continuing Education Controlled Clinical Trials Coupled Critical Care Critical Illness Critiques Cultured Cells Cysteine Cystic Fibrosis Cystine Cytoprotection Daily Dana-Farber Cancer Institute Data Dedications Development Diabetes Mellitus Diarrhea Diet Diet Research Dietary Proteins Dietary Sulfur Dietary Supplementation Dietary intake Digestive System Disorders Dipeptides Discipline Disease Doctor of Medicine Doctor of Philosophy Dose Double-Blind Method Down-Regulation EGF gene Education Educational Curriculum Educational process of instructing End Point Endocrinology Engraftment Enrollment Enteral Enteral Nutrition Environment Epidemic Epithelial Epithelial Cells Epithelium Equilibrium Equipment Excision Exhibits Exposure to Extracellular Fluid Faculty Failure Fellowship Female Flagellin Food deprivation (experimental)Fostering Foundations Functional disorder Fund Raising Funding Funding Opportunities Future GAG Gene GLP-2 Gastric Bypass Gastroenterologist Gastroenterology Gene Proteins Gene Targeting General Hospitals Generations Genes Germany Glucose Glutamine Glutathione Goals Grant Growth Growth Factor Growth Factor Interaction HT29 Cells Health Health Sciences Hematology Hemodialysis Hormones Hospital Costs Hospital Mortality Hospitals House Staffs Human Human Resources Hypersensitivity Immune Immune response Immunity Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulins In Vitro Incidence Income Individual Industry Infant Infection Inflammation Inflammatory Inflammatory Bowel Diseases Institute of Medicine (U.S.)Institutes Institution Insulin Insulin Resistance Insulin-Like Growth Factor I Intake Intensive Care Units Interdisciplinary Study Interleukin-6 Internal Medicine Internist Internships Intervention Intestinal Absorption Intestines Intravenous Investigation Iowa Isoprostanes Israel Italy Japan Joints Journals Junior Physician Kidney Kidney Failure Laboratories Laboratory Technicians Lead Leadership Learning Left Legal patent Length of Stay Letters Light Link Lipids Lipopolysaccharides Liquid substance Literature Lobbying Lung Macronutrients Nutrition Malignant Neoplasms Malnutrition Manuscripts Master of Public Health Master of Science Measurement Measures Mechanical ventilation Medial Mediating Mediator of activation protein Medical Medical Education Medical Students Medical center Medicine Mediterranean Diet Mentored Clinical Scientist Development Program Mentors Mentorship Messenger RNA Metabolic Metabolic syndrome Metabolism Metalloproteases Methodology Methods Mexican Michigan Microbiology Micronutrients Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Minority Mission Modality Modeling Molecular Molecular Biology Moods Morbidity - disease rate Motor Mucous Membrane Multicenter Studies NCI Scholars Program Names National Center for Research Resources National Institute of Diabetes and Digestive and Kidney Diseases National Research Service Awards Neurology Nigeria Nomads North Carolina Nosocomial Infections Numbers Nurses Nutrient Nutritional Nutritional Study Nutritional Support Nutritionist Obesity Ohio Operative Surgical Procedures Oral Osteopathic Medicine Outcome Oxandrolone Oxidation-Reduction Oxidative Stress Paper Parenteral Nutrition Parkinson Disease Pathway interactions Patients Pediatric Neurology Pediatrics Peer Review PepT1 protein Peptides Performance Pharmacists Pharmacology Phase Phase II Clinical Trials Physicians Pilot Projects Placebo Control Plasma Play Population Positioning Attribute Postdoctoral Fellow Preparation Prevention Preventive Primates Principal Investigator Problem-Based Learning Program Research Project Grants Protein Chemistry Protein-Energy Malnutrition Proteins Proteomics Protocols documentation Psychiatry Public Health Schools Publications Publishing Publishing Peer Reviews Pyrimidine Pyrimidines Quality of life Randomized Randomized Controlled Clinical Trials Randomized Controlled Trials Rate Rattus Reading Receptor Signaling Recombinant Growth Factor Recombinant Growth Hormone Recombinants Recommendation Recording of previous events Recruitment Activity Regulation Rehabilitation therapy Rehydrations Relative (related person)Reporting Research Research Design Research Personnel Research Project Grants Research Training Residencies Residual state Resistance Resolution Resources Role Rotation Rural SECTM1 gene Safety Sampling Satiation Schools Science Scientist Score Sepsis Series Serum Services Short Bowel Syndrome Sickle Cell Anemia Site Skeletal Muscle Skeleton Small Intestines Societies Somatomedins Somatotropin Source Spain Specialist Staging Standards of Weights and Measures Staphylococcus aureus Stomach Stress Students Study Subject Sulfur Sulfur Amino Acids Supplementation Support of Research Surgeon Symptoms Syndrome System T-Lymphocyte Techniques Technology Tern Testing Thalassemia Therapeutic Agents Thioredoxin Time Tissues Title Tokyo Total Parenteral Nutrition Toxic effect Training Training Programs Transgenic Animals Translating Translational Research Transplantation Trefoil USA Georgia United States United States Food and Drug Administration United States National Institutes of Health Universities University Hospitals Up-Regulation Uracil Variant Visceral Vitamin D Weaning Week Weight Western Asia Georgia Woman Work Writing Zinc Zinc deficiency absorption abstracting bacterial resistance base career cell growth clinical effect clinical efficacy college comparative concept conditionally essential amino acid cytokine day design dietary supplements editorial experience extracellular farm worker fascinate food science ghrelin hospital laboratories improved in vivo indexing instructor insulin sensitivity interest keratinocyte growth factor lectures lipid metabolism liver transplantation man medical schools member metabolic abnormality assessment metabolomics microbial colonization mortality multidisciplinary nitrogen balance novel nutrition nutrition education oncology oral mucositis orotate oxidation patient oriented research pediatric department pilot trial pre-clinical prevent professor programs prospective protein expression r-hGH-M ranpirnase repaired research and development research study response role model sickling size skills success symposium tool translational study tube feeding

项目摘要

DESCRIPTION (provided by applicant): This application for a Midcareer Investigator Award in Patient Oriented Research (K24) seeks support for a physician nutrition specialist and established investigator in clinical and translational nutrition science. The P.I. is committed to performing patient-oriented research (POR), focused on nutrition, and in mentoring clinical residents, fellows and junior faculty in clinical nutrition research to develop a new cadre of investigators in Clinical Nutrition. This proposal will provide protected time to enable the P.I. to advance his research and mentoring efforts in nutrition-oriented research, and provide additional training and resources that will in turn enhance his ability to mentor physicians and other clinical investigators in nutrition-related studies. The applicant has a unique training background in nutrition and medicine and an excellent record of federal, foundation and industry funding for his investigator-initiated POR and translational research. He has a strong publication record and a history of leadership roles in national nutrition-related societies and service on editorial boards of front-line nutrition journals. At Emory, the P.I. serves in the leadership of the NIH-funded GCRC, K12 Emory Mentored Clinical Research Scholars (EMCRS) and K30 Masters of Science in Clinical Research (MSCR) programs, the Center for Clinical and Molecular Nutrition and the graduate program in Nutrition and Health Science - all of which provide opportunities for mentoring in POR. The P.I. has mentored more than 18 trainees, including a current cadre of 5 physician junior faculty members in Medicine, Surgery, Neurology and Pediatrics, 2 Ph.D. junior faculty clinical investigators, and 3 Ph.D. students who conduct both clinical and translational nutrition research. The candidate's research program includes GCRC-based studies on the efficacy and mechanisms of glutamine in catabolic states, including critical care and sickle cell anemia, on metabolic adaptation in short bowel syndrome and after medical/surgical weight loss, and studies on diet-related redox control. The specific aims of this K24 are: 1) to provide protected time enabling the P.I. to increase his mentoring activities among current and new trainees in POR; 2) to facilitate the P.I.'s development of new research skills in nutritional metabolomics and new redox-related measures within the context of his current clinical research, enabling him to train mentees in these new measures; and 3) to faciliate the career development of the applicant.

描述（由申请人提供）：本申请以患者为导向的研究（K24）中的职业生涯中期研究员奖寻求对临床和转化营养科学领域的医师营养专家和知名研究员的支持。 P.I.致力于开展以患者为中心的研究（POR），重点关注营养学，并指导临床营养研究领域的临床住院医生、研究员和初级教师，以培养临床营养领域的新研究人员骨干。该提案将为 P.I. 提供受保护的时间。推进他在营养导向研究方面的研究和指导工作，并提供额外的培训和资源，从而增强他在营养相关研究中指导医生和其他临床研究人员的能力。申请人在营养和医学方面拥有独特的培训背景，并在其研究者发起的 POR 和转化研究中获得联邦、基金会和行业资助的良好记录。他拥有良好的发表记录，并在国家营养相关学会中担任领导职务，并在一线营养期刊的编辑委员会任职。在埃默里大学，P.I.领导 NIH 资助的 GCRC、K12 埃默里指导临床研究学者 (EMCRS) 和 K30 临床研究理学硕士 (MSCR) 项目、临床和分子营养中心以及营养与健康科学研究生项目 -所有这些都提供了 POR 指导的机会。 P.I.已指导超过 18 名学员，其中包括 5 名现任内科、外科、神经病学和儿科医师初级教员，2 名博士生。初级临床研究人员和 3 名博士。进行临床和转化营养研究的学生。该候选人的研究项目包括基于 GCRC 的谷氨酰胺在分解代谢状态（包括重症监护和镰状细胞性贫血）中的功效和机制的研究、短肠综合征和药物/手术减肥后的代谢适应的研究，以及与饮食相关的氧化还原的研究控制。 K24 的具体目标是：1) 提供受保护的时间，使 P.I.加强对 POR 现有学员和新学员的指导活动； 2) 促进 P.I. 在其当前临床研究的背景下发展营养代谢组学和新的氧化还原相关措施方面的新研究技能，使他能够对学员进行这些新措施的培训； 3) 促进申请人的职业发展。