Clinical Translation of a One-Stop-Shop Imaging Method for Abdominal CT

腹部 CT 一站式成像方法的临床转化

• 批准号: 10686103
• 负责人: Guang-Hong Chen
• 金额: $ 60.18万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686103
• 关键词: Abdomen; Academic Medical Centers; Address; Adrenal Glands; Anatomy; Attenuated; Clinical; Community Hospitals; Compton radiation; Computed Tomography Scanners; Data; Data Set; Developing Countries; Development; Diagnosis; Diagnostic; Dose; Elements; Environment; Evaluation; Future; Health Care Costs; Hospitals; Image; Imaging Techniques; Incidental Findings; Iodine; Lipids; Magnetic Resonance Imaging; Maps; Measurement; Measures; Medical; Methods; Modern Medicine; Modernization; Modification; Nodule; Pathway interactions; Patients; Penetration; Performance; Phase; Photons; Process; Radiation Dose Unit; Radiology Specialty; Research; Resolution; Roentgen Rays; Scanning; Series; Signal Transduction; Source; Speed; System; Techniques; Technology; Translating; Tube; X-Ray Computed Tomography; X-Ray Medical Imaging; abdominal CT; absorption; adenoma; attenuation; clinical application; clinical diagnostics; clinical implementation; clinical practice; clinical translation; community clinic; contrast enhanced; contrast enhanced computed tomography; detector; diagnostic accuracy; diagnostic tool; disease diagnosis; experience; image reconstruction; imaging facilities; imaging modality; imaging system; improved; innovation; novel; quantitative imaging; radiation risk; spectral energy; success; technology platform; temporal measurement; tool; uptake; virtual

ABSTRACT CT imaging is one of the primary diagnostic tools utilized in modern radiology departments, and its importance to modern medicine cannot be overstated. In recent years, spectral CT technologies have been developed to address one of the long-standing technical limitations associated with conventional single-kV CT imaging: anatomical structures with different material compositions may have the same CT number for a given acquisition. Current spectral CT imaging systems have been implemented using advanced x-ray source and/or detector technologies that enable image objects to be rapidly scanned using two distinct x-ray spectra. However, these hardware-based spectral CT systems are not without their own intrinsic limitations. Such limitations include a reduced field-of-view, slower scan speeds, misregistration between the high kV and low kV measurements in dual source systems, lack of tube current modulation for many fast kV-switching systems, and having other clinical workflow/efficiency challenges. In this application, we propose to implement and translate a novel single- kV spectral CT imaging method for abdominal CT applications that overcomes the limitations associated with current spectral CT imaging methods. With this new method, all conventional contrast-enhanced single-kV abdominal CT exams can be used to generate a deluxe series of CT images with the desired spectral CT functionalities including virtual non-contrast CT images, virtual mono-energetic CT images, and quantitative material basis images (i.e., one-stop-shop). This new method enables an integrated clinical workflow to improve clinical diagnostic accuracy while reducing both radiation dose and contrast dose to patients, all while reducing overall healthcare costs. Three specific aims will be carried out to accomplish the overarching objective of this project: 1) Implement and optimize techniques to achieve one-stop-shop single-kV spectral CT imaging for abdominal applications; 2) Validate the proposed one-stop-shop single-kV spectral CT imaging method using the hardware based spectral CT imaging methods; and 3) translate the one-stop-shop single-kV spectral CT imaging method to the clinical environment for clinical performance evaluations. Upon the completion of this project, a unique one-stop-shop CT imaging paradigm will have been implemented and translated to clinical abdominal CT exams to enable one-stop-shop abdominal CT diagnoses with just a single-kV contrast-enhanced CT acquisition. This new technique can be made available to all types of imaging facilities including community hospitals or clinics in developing nations, which is in stark contrast to hardware dual-energy CT and photon counting CT imaging which has been traditionally reserved to high profile academic medical centers that can afford the latest technological platforms.

抽象的 CT成像是现代放射科使用的主要诊断工具之一，其重要性 对现代医学的影响怎么强调都不为过。近年来，能谱CT技术的发展 解决与传统单 kV CT 成像相关的长期存在的技术限制之一： 对于给定的采集，具有不同材料成分的解剖结构可能具有相同的 CT 数。 当前的光谱 CT 成像系统已使用先进的 X 射线源和/或探测器来实现 能够使用两种不同的 X 射线光谱快速扫描图像对象的技术。然而，这些 基于硬件的能谱 CT 系统并非没有其固有的局限性。这些限制包括 视野缩小、扫描速度变慢、高 kV 和低 kV 测量之间的重合失调 双源系统，许多快速千伏开关系统缺乏管电流调制，并且具有其他 临床工作流程/效率挑战。在此应用中，我们建议实现并翻译一种新颖的单 用于腹部 CT 应用的 kV 能谱 CT 成像方法，克服了与 当前的能谱CT成像方法。通过这种新方法，所有传统的对比度增强单kV 腹部 CT 检查可用于生成一系列具有所需能谱 CT 的豪华 CT 图像 功能包括虚拟非造影 CT 图像、虚拟单能 CT 图像和定量 物质基础图像（即一站式服务）。这种新方法使集成的临床工作流程能够改善 临床诊断准确性，同时减少患者的辐射剂量和造影剂剂量，同时减少 总体医疗费用。为实现本次总体目标，将实施三个具体目标 项目：1）实施和优化技术，以实现一站式单kV能谱CT成像 腹部应用； 2) 使用以下方法验证所提出的一站式单 kV 能谱 CT 成像方法 基于硬件的能谱CT成像方法； 3）转化一站式单kV能谱CT 成像方法对临床环境进行临床性能评估。本次完成后 项目中，独特的一站式 CT 成像范式将得到实施并转化为临床 腹部 CT 检查，仅需单 kV 增强造影即可实现一站式腹部 CT 诊断 CT 采集。这项新技术可用于所有类型的成像设施，包括社区 发展中国家的医院或诊所，这与硬件双能CT和光子形成鲜明对比 传统上只有知名学术医疗中心才能使用的 CT 成像计数 负担得起最新的技术平台。