NEUROPATHOLOGY CORE

神经病理学核心

• 批准号: 7437355
• 负责人: CAROL A MILLER
• 金额: $ 9.38万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7437355
• 关键词: Aging; Alzheimer' s Disease; Amyloid beta-Protein; Ants; Apolipoprotein E; Autopsy; Basic Science; Behavioral; Biochemistry; Biological Models; Blood Vessels; Blood specimen; Brain Hypoxia-Ischemia; Cerebrovascular Disorders; Clinical; Clinical Research; Data; Databases; Dementia; Diagnosis; Diagnostic; Diagnostics Research; Disease; Dissection; Educational workshop; Enrollment; Fresh Tissue; Frontotemporal Dementia; Funding; Future; Genetic Transcription; Genotype; Gifts; Goals; Gonadal Steroid Hormones; Hour; Human; Hyperlipidemia; Inflammation; Institutes; Journals; Latino; Lewy Bodies; Link; Longitudinal Studies; Molecular; Molecular Biology; Neurobiology; Neurologic; Neurologist; Oxidants; Pathology; Patients; Peer Review; Pick Disease of the Brain; Play; Preparation; Protocols documentation; Psychometrics; Publications; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Services; Severities; Stress; Tauopathies; Tissue Procurements; Tissues; Training; Vascular Dementia; abstracting; base; design; experience; neuroimaging; neuropathology; programs; tissue preparation

The Pathology Core provides tissue diagnoses of Alzheimer's disease (AD), cerebrovascular disease (CVD) and related dementias and links the clinical studies with basic research by project-driven tissue procurement and allocation. The diagnostic protocol integrates components of the CERAD program and Braak and Braak parameters recommendeq by the NIA-Reagan Institute Workshop Group and the IVD program project protocol. During the current funding period, the Core played an integral role in project design, serving a total of 41 funded investigators conducting 43 projects yielding 44 publications in peer review journals, and 42 abstracts. In the renewal, projects of 26 investigators located at 8 academic centers emphasize oxidant stress, CVD, hypoxia/ischemia, Abeta, sex hormones, inflammation, an? aging. Tissues are mainly obtained from patients enrolled in the USC Clinical Core, Spanish-Speaking Satellite, and from the USC Anatomical Gift Program. Neuropathology correlates will be available for future extensions of Projects 1 and 3.A 24-hour autopsy service minimizes post-mortem delay and insures high-fidelity preparation for biochemistry, molecular biology, RNA expression. The Core provides reliable neuroanatomical dissections and secialized tissue preparations (e.g., "fresh" tissue for 9 studies). The Core will also coordinate genotyping for risk factors (e.g., ApoE) from post-mortem tissue, as well as from blood samples obtained by the Clinical Core, Spanish Speaking Satellite, ant Project 2. Currently, clinical information including dementia severity and neuropathology diagnostic data are accessible online through the ADRC website. Neuropathological data is shared on an ongoing basis with the National Alzheimer's Coordinating Center (NACC).

病理核心提供了组织诊断阿尔茨海默氏病（AD），脑血管疾病（CVD）和相关痴呆症，并将临床研究与项目驱动的组织采购和分配联系起来。诊断协议集成了Nia-Reagan Institute Workshop Group和IVD计划项目协议推荐Cerad计划的组成部分以及Braak和Braak参数。在当前的资助期间，核心在项目设计中发挥了不可或缺的作用，为41位资助的调查人员提供了43个项目，在同行评审期刊上产生44个出版物，并提供42个摘要。在续签中，位于8个学术中心的26个研究人员的项目强调了氧化应激，CVD，缺氧/缺血，Abeta，性激素，炎症，AN？老化。组织主要是从USC临床核心，讲西班牙语的卫星和USC解剖学礼物计划的患者中获得的。神经病理学相关性将用于项目1和3. 24小时的尸检服务的未来扩展，可最大程度地减少验尸延迟，并确保生物化学，分子生物学，RNA表达的高保真准备。核心提供可靠的神经解剖解剖和隔离组织制剂（例如，“新鲜”组织进行9项研究）。核心还将协调验尸后组织的危险因素（例如APOE）的基因分型，以及临床核心，西班牙语卫星，ANT Project 2获得的血液样本。神经病理学数据与国家阿尔茨海默氏症协调中心（NACC）不断共享。