Affective and Cognitive Mechanisms of Emotion-Based Impulsivity in Bipolar Disorder: Linking Neural Oscillatory Dynamics to Real-World Outcomes

双相情感障碍中基于情绪的冲动的情感和认知机制：将神经振荡动力学与现实世界的结果联系起来

基本信息

批准号：
10735028
负责人：
Sarah Havens Sperry
金额：
$ 19.66万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-08 至 2028-07-31
项目状态：
未结题

项目摘要

Projective Summary/Abstract Individuals with bipolar disorder (BD) experience severe and persistent difficulties with impulsivity, especially when experiencing strong emotions. Emotion-based impulsivity is associated with increased hospitalizations, lost relationships, substance use, and suicide. Yet, mechanisms underlying emotion-based impulsivity are not well understood, limiting the design of effective interventions. To this end, the Candidate aims to use multimodal assessments to identify candidate mechanisms of emotion-based impulsivity in the lab and daily life. This K23 proposal has two goals: 1) to delineate neurophysiological indicators of cognitive control using electroencephalogram (EEG) and their association with real-world emotion-based impulsivity in daily life measured with ecological momentary assessment (EMA); and 2) To provide the Candidate with training in affective neuroscience and experimental psychopathology (training objective 1), EEG methods and analysis (training objective 2), and intensive longitudinal modeling (training objective 3), to accelerate clinical translational research (training objective 4) in BD. The proposed project will study 90 adults across the entire bipolar spectrum (30 healthy controls, 30 subclinical BD, and 30 diagnosed BD) drawn from the well-established Prechter Longitudinal Cohort ( n = 1,394) at the University of Michigan. Participants will complete trait measures of emotion-based impulsivity, an affective inhibition paradigm while undergoing an EEG, and a 28-day EMA protocol developed to assess momentary affective arousal, emotion regulation, and impulsivity. The research specific aims are to: 1) Identify neurophysiological components of cognitive control that are associated with trait and lab-based emotion-based impulsivity, and 2) Evaluate the extent to which these components are associated with emotion-based impulsivity in real-world settings. This proposed research is innovative in examining neural oscillations and synchrony embedded in EEG signals as a mechanism of emotion-based impulsivity and linking it with real-world behavior using ecological momentary assessment. It has significant implications because it could yield novel neural and cognitive treatment targets (e.g., neuromodulation of theta-band activity as an adjunct to psychosocial interventions) to improve emotion- based impulsivity in BD after further mechanistic studies. The Candidate is supported by a team of mentors and consultants who are leading experts in translational clinical science and areas of proposed training: Dr. Ivy Tso (Primary Mentor, EEG methods and analysis), Dr. Melvin McInnis (Co-Mentor, bipolar disorder, responsible conduct of research), Dr. David Fresco (Consultant: affective neuroscience, emotion regulation), Dr. Daniel McNeish (Statistical Consultant: intensive longitudinal modeling), Dr. Flavio Frohlich (Consultant: EEG time frequency analysis) and Dr. Sheri Johnson (Consultant: emotion-based impulsivity). This career development award is critical for advancing the Candidate’s independent program of research and long-term goal to identify and refine targets for personalized interventions in BD.

投射总结/摘要双相情感障碍 (BD) 患者会经历严重且持续的冲动困难，尤其是当经历强烈的情绪时，冲动会增加。然而，住院治疗、失去人际关系、药物滥用和自杀是基于情绪的机制。冲动性尚未得到很好的理解，限制了有效干预措施的设计。旨在使用多模式评估来识别实验室中基于情绪的冲动的候选机制这个 K23 提案有两个目标：1）描绘认知的神经生理学指标。使用脑电图（EEG）进行控制及其与现实世界中基于情绪的冲动的关联通过生态瞬时评估 (EMA) 衡量日常生活；以及 2) 向候选人提供情感神经科学和实验精神病理学培训（培训目标 1）、脑电图方法和分析（培训目标 2），以及强化纵向建模（培训目标 3），加速 BD 的临床转化研究（培训目标 4）拟议项目将研究 90。整个双相情感障碍谱系的成年人（30 名健康对照、30 名亚临床双相情感障碍和 30 名诊断双相情感障碍）来自完善的 Prechter 纵向队列（ n = 1,394) 在密歇根大学。将完成基于情绪的冲动的特征测量，这是一种情感抑制范式，同时经历 EEG 和 28 天 EMA 协议旨在评估瞬时情感唤醒、情绪调节和研究的具体目标是：1）识别认知控制的神经生理学组成部分。那与特质和基于实验室的基于情绪的冲动，以及 2) 评估其程度这些组件与这提出了现实世界中基于情绪的冲动。研究在检查脑电图信号中嵌入的神经振荡和同步性方面具有创新性基于情绪的冲动机制，并利用生态瞬时将其与现实世界的行为联系起来它具有重大意义，因为它可以产生新的神经和认知治疗目标。（例如，作为社会心理干预的辅助手段，对 θ 带活动进行神经调节）以改善情绪经过进一步的机制研究后，候选人得到了导师团队的支持。转化临床科学和拟议培训领域的领先专家顾问：Ivy 博士 Tso（主要导师，脑电图方法和分析），Melvin McInnis 博士（共同导师，双相情感障碍，负责任的研究行为），David Fresco 博士（顾问：情感神经科学、情绪调节）， Daniel McNeish 博士（统计顾问：纵向强化建模）， Flavio Frohlich 博士（顾问：脑电图时频分析）和 Sheri Johnson 博士（顾问：基于情绪的冲动）。发展奖对于推进候选人的独立研究计划和长期发展至关重要目标是确定和完善 BD 个性化干预的目标。