Migrant and Multi-generational Immigrant Experiences: The Effects of Stressors on Epigenetic, Behavioral, and Health-related Outcomes

移民和多代移民经历：压力源对表观遗传、行为和健康相关结果的影响

• 批准号: 10693366
• 负责人: TIMOTHY D HOWARD
• 金额: $ 64.49万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-30 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693366
• 关键词: Acute; Address; Affect; Age; Behavior; Behavioral; Biological; Biological Markers; Blood specimen; Buffers; Cell Aging; Characteristics; Chromosomes; Chronology; Country; DNA Methylation; Data; Data Analyses; Data Collection; Development; Disease; Economics; Education; Educational Status; Emotional; Employment; Epigenetic Process; Etiology; Event; Face; Gene Expression Profile; General Population; Generations; Goals; Health; Heart Diseases; Immigrant; Immigration; Individual; Interview; Latinx; Length; Life; Life Style; Longevity; Measurable; Measurement; Measures; Mediating; Mental Health; Mexican; Migrant; Migrant Workers; North Carolina; Occupations; Outcome; Participant; Personal Satisfaction; Physiological; Population; Process; Religious Belief; Research; Resources; Shapes; Social support; Stress; Stressful Event; Structure; Telomere Shortening; Translating; Trauma; United States; Variant; Violence; Work; age group; age related; behavioral health; biological systems; design; disease phenotype; early childhood; epigenomics; experience; graduate school; health disparity; high school; improved; migration; peripheral blood; physical conditioning; psychologic; public health research; response; stressor; structural determinants; telomere

PROJECT SUMMARY Immigrant populations face substantial adversity and acculturative stressors, with educational and work related stressors often at the forefront. A substantial percentage of Mexican immigrants have very limited education. They experience both economic and non-economic stressors in the United States. Paradoxically, immigrant populations, including those of Mexican immigrants, generally have better health outcomes than subsequent US-born generations. Recent research indicates that individual experiences and stress exposures translate into physical changes to biological systems. For example, elevated stressors, such as those caused by violence or trauma, can result in shortened chromosome telomeres. Telomere shortening is considered a marker of cellular aging, and contributes to earlier development of age-related diseases, such as heart disease. Resources, such as strong social support and religious beliefs, may buffer the negative impact of the stressors. The variation in lived experiences of first and second generation immigrants and migrants, as well as differential cumulative stress may be evident in biological markers, such as telomere length and DNA methylation, allowing for a deeper understanding of the etiology of persistent health disparities. The goal of this study is to determine how immigrant experiences influence individuals’ short- and long-term behavioral, psychological, and physical health outcomes. This study will compare the experiences among first- and second-generation Mexican immigrants and migrants living in North Carolina. We will conduct and analyze 60 semi-structured, in-depth interviews, subsequently administer closed-ended interviews with 375 first and second generation immigrants and migrants, and collect a peripheral blood sample to analyze telomere length and DNA methylation. This data will enable us to (1) identify commonalities and differences among first- and second-generation and migrants’ experiences, particularly as they relate to immigrant or migrant experiences using a qualitative data collection and analysis approach, (2) examine the association between first- and second-generation and migrants’ experiences and behavioral, psychological, and physical outcomes using a quantitative analytics approach, and (3) determine if measures of biological age, as measured by telomere length and DNA methylation, are associated with generation of immigration or immigrant/migrant status and physical, emotional, and behavioral well-being. This project is significant because it will enable us to examine immigration is a unique life event and presents a unique set of stressors. The paradoxical relationship between first- and second-generation immigrants and health outcomes suggests that the immigrant experience contributes to these differences. This project is designed to identify the stressors involved in immigration as well as protective buffers, and potentially the biological mechanisms they target, with the potential goal of identify strategies to improve the behavioral, psychological, and physical health of immigrants and subsequent generations.

项目摘要 移民人口面临着实质性的广告和适应性压力源，并与教育和工作有关 压力源经常处于最前沿。墨西哥移民中有很大一部分的教育程度非常有限。 他们在美国经历经济和非经济压力源。矛盾的是移民 包括墨西哥移民在内的人口通常比随后的人口更好 美国出生的世代。最近的研究表明，个人经历和压力暴露会翻译 变成生物系统的物理变化。例如，压力升高，例如 暴力或创伤可能导致染色体端粒缩短。端粒缩短被认为是 细胞衰老的标志物，并有助于早期发展与年龄相关疾病的发展，例如心脏 疾病。资源，例如强烈的社会支持和宗教信仰，可能会缓冲 压力源。第一代和第二代移民和移民的现场经历的差异以及 差异累积应激可能是生物学标记中的证据，例如端粒长度和DNA 甲基化，可以更深入地了解持续性健康差异的病因。目标的目标 研究是为了确定移民经历如何影响个人的短期和长期行为， 心理和身体健康成果。这项研究将比较第一和第一的经验 第二代墨西哥移民和居住在北卡罗来纳州的移民。我们将进行和分析60 半结构化的深入访谈，随后对375的封闭式访谈首先进行 第二代移民和移民，并收集外围血液样本以分析端粒长度 和DNA甲基化。这些数据将使我们能够（1）确定第一和第一之间的共同点和差异 第二代和移民的经历，尤其是与移民或移民经历有关的 使用定性数据收集和分析方法，（2）检查第一和 第二代和移民的经验以及行为，心理和身体结果使用 定量分析方法，以及（3）确定端粒测量的生物年龄测量方法是否 长度和DNA甲基化与移民或移民/移民状况的产生有关 身体，情感和行为健康。该项目很重要，因为它将使我们能够检查 移民是一个独特的生活事件，并提出了一套独特的压力源。之间的悖论关系 第一代和第二代移民和健康成果表明，移民经历 有助于这些差异。该项目旨在确定涉及移民的压力源 以及受保护的缓冲液，以及他们针对的生物学机制，其潜在目标 确定改善移民行为，心理和身体健康的策略以及随后的步骤 几代人。