Migrant and Multi-generational Immigrant Experiences: The Effects of Stressors on Epigenetic, Behavioral, and Health-related Outcomes

移民和多代移民经历：压力源对表观遗传、行为和健康相关结果的影响

• 批准号: 10530936
• 负责人: TIMOTHY D HOWARD
• 金额: $ 59.12万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-30 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10530936
• 关键词: Acute; Address; Affect; Age; Behavior; Behavioral; Biological; Biological Markers; Blood specimen; Buffers; Cell Aging; Characteristics; Chromosomes; Chronology; Country; DNA Methylation; Data; Data Analyses; Data Collection; Development; Disease; Economics; Education; Educational Background; Emotional; Employment; Epigenetic Process; Etiology; Event; Face; Gene Expression Profile; General Population; Generations; Goals; Health; Heart Diseases; Immigrant; Immigration; Individual; Interview; Latinx; Length; Life; Life Style; Longevity; Measurable; Measurement; Measures; Mediating; Mental Health; Mexican; Migrant; Migrant Workers; North Carolina; Occupations; Outcome; Participant; Personal Satisfaction; Physiological; Population; Process; Religious Belief; Research; Resources; Shapes; Social support; Stress; Stressful Event; Structure; Telomere Shortening; Translating; Trauma; United States; Variant; Violence; Work; age group; age related; behavioral health; biological systems; design; disease phenotype; early childhood; epigenomics; experience; health disparity; high school; improved; migration; peripheral blood; physical conditioning; psychologic; public health research; response; stressor; telomere

PROJECT SUMMARY Immigrant populations face substantial adversity and acculturative stressors, with educational and work related stressors often at the forefront. A substantial percentage of Mexican immigrants have very limited education. They experience both economic and non-economic stressors in the United States. Paradoxically, immigrant populations, including those of Mexican immigrants, generally have better health outcomes than subsequent US-born generations. Recent research indicates that individual experiences and stress exposures translate into physical changes to biological systems. For example, elevated stressors, such as those caused by violence or trauma, can result in shortened chromosome telomeres. Telomere shortening is considered a marker of cellular aging, and contributes to earlier development of age-related diseases, such as heart disease. Resources, such as strong social support and religious beliefs, may buffer the negative impact of the stressors. The variation in lived experiences of first and second generation immigrants and migrants, as well as differential cumulative stress may be evident in biological markers, such as telomere length and DNA methylation, allowing for a deeper understanding of the etiology of persistent health disparities. The goal of this study is to determine how immigrant experiences influence individuals’ short- and long-term behavioral, psychological, and physical health outcomes. This study will compare the experiences among first- and second-generation Mexican immigrants and migrants living in North Carolina. We will conduct and analyze 60 semi-structured, in-depth interviews, subsequently administer closed-ended interviews with 375 first and second generation immigrants and migrants, and collect a peripheral blood sample to analyze telomere length and DNA methylation. This data will enable us to (1) identify commonalities and differences among first- and second-generation and migrants’ experiences, particularly as they relate to immigrant or migrant experiences using a qualitative data collection and analysis approach, (2) examine the association between first- and second-generation and migrants’ experiences and behavioral, psychological, and physical outcomes using a quantitative analytics approach, and (3) determine if measures of biological age, as measured by telomere length and DNA methylation, are associated with generation of immigration or immigrant/migrant status and physical, emotional, and behavioral well-being. This project is significant because it will enable us to examine immigration is a unique life event and presents a unique set of stressors. The paradoxical relationship between first- and second-generation immigrants and health outcomes suggests that the immigrant experience contributes to these differences. This project is designed to identify the stressors involved in immigration as well as protective buffers, and potentially the biological mechanisms they target, with the potential goal of identify strategies to improve the behavioral, psychological, and physical health of immigrants and subsequent generations.

项目概要 移民人口面临巨大的逆境和文化压力，与教育和工作相关 很大一部分墨西哥移民的受教育程度非常有限。 矛盾的是，他们在美国经历了经济和非经济压力。 人口，包括墨西哥移民，通常比后来的移民有更好的健康结果 最近的研究表明，美国出生的几代人的个人经历和压力暴露会产生影响。 生物系统的物理变化，例如压力源升高，例如由以下原因引起的压力源。 暴力或创伤，可导致染色体端粒缩短 端粒缩短被认为是一种。 细胞衰老的标志，并有助于与年龄相关的疾病（例如心脏病）的早期发展 强大的社会支持和宗教信仰等资源可以缓冲疾病的负面影响。 第一代和第二代移民以及移民的生活经历的差异。 不同的累积压力可能在端粒长度和 DNA 等生物标记中很明显 甲基化，使人们能够更深入地了解持续健康差异的病因。 研究的目的是确定移民经历如何影响个人的短期和长期行为， 这项研究将比较首次和身体健康结果。 我们将对第二代墨西哥移民和居住在北卡罗来纳州的移民进行分析。 半结构化、深入访谈，随后对 375 名初次和 第二代移民和移民，并采集外周血样本分析端粒长度 这些数据将使我们能够 (1) 确定第一和第二个之间的共同点和差异。 第二代和移民的经历，特别是与移民或移民经历相关的经历 使用定性数据收集和分析方法，（2）检查第一和第二之间的关联 第二代和移民的经历以及行为、心理和身体结果 定量分析方法，以及（3）确定生物年龄的测量（通过端粒测量） 长度和 DNA 甲基化，与移民的产生或移民/移民身份有关， 这个项目意义重大，因为它将使我们能够检查身体、情感和行为的健康。 移民是一个独特的生活事件，并呈现出一系列独特的压力源之间的矛盾关系。 第一代和第二代移民以及健康结果表明，移民经历 该项目旨在确定移民中涉及的压力源： 以及保护性缓冲液，以及它们所针对的潜在生物机制，其潜在目标是 确定改善移民及其后续行为、心理和身体健康的策略 几代人。