Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

体位性心动过速综合征 (POTS) 的多模态深度表型分析

基本信息

批准号：
10733708
负责人：
BENJAMIN D LEVINE
金额：
$ 168.44万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10733708
关键词：
Acute Affect Agreement American Ancillary Study Biochemical Biological Biological Specimen Banks Blood Tests Blood Volume Blood specimen Cardiac Characteristics Chronic Chronic Disease Classification Clinical Cluster Analysis Collaborations Complex Data Data Set Derivation procedure Diagnostic Evaluation Exercise Exercise Test Funding Future Gases Genomics Goals Health Heart Immune system Immunologic Markers Immunophenotyping Impairment Individual Investigation Laboratories Measures Metabolism Modality Modification Molecular Monitor Morbidity - disease rate Muscle Normal Range Outcome Outcome Measure Participant Patients Phenotype Physical activity Physiological Postural Orthostatic Tachycardia Syndrome Procedures Proteomics Protocols documentation Publishing Quality of life Regulation Reporting Research Research Personnel Resolution Skeletal Muscle Structure Symptoms Syndrome Testing Therapeutic Training Transducers United States National Institutes of Health clinical database clinical phenotype clinically relevant cohort comparative conditioning design diagnostic tool disabling disease disabling symptom exercise intensity exercise intolerance exercise program exercise training falls fitness follow-up hemodynamics improved individualized medicine innovation metabolomics multimodal data multimodality novel novel therapeutics orthostatic intolerance predicting response productivity loss prognostic value programs recruit research study response standard of care

项目摘要

Project summary Postural orthostatic tachycardia syndrome (POTS) is a chronic disorder causing disabling symptoms and substantial loss of productivity. Not all POTS patients are the same, and the causes and significance of different subtypes are not known. For example, some patients may have abnormal regulation of their immune system while others may have problems with the response of their muscles to activity. Exercise training has been shown to be a beneficial treatment for POTS, but about 25% of patients are unable to complete the exercise program. Our research study will examine the different types of POTS by systematically and comprehensively studying a large diverse group of patients. This will include careful assessment of symptoms, blood tests, and heart structure as well as a detailed analysis of the muscle response to exercise. This study will be the first to define the full picture of different POTS subtypes and the relationship between these subtypes. Our studies will allow clinicians to better evaluate and individualize treatment and will guide future POTS research.

项目概要体位性直立性心动过速综合征 (POTS) 是一种慢性疾病，可导致失能症状和生产力的严重损失。并非所有 POTS 患者都是相同的，不同的原因和意义亚型尚不清楚。例如，一些患者的免疫系统可能出现异常调节，同时其他人可能会出现肌肉对活动的反应问题。运动训练已被证明是一种对 POTS 有益的治疗，但约 25% 的患者无法完成锻炼计划。我们的研究将通过系统、全面地研究 POTS 的不同类型大量不同的患者群体。这将包括仔细评估症状、血液检查和心脏结构以及肌肉对运动反应的详细分析。这项研究将是第一个定义整体情况的研究不同 POTS 子类型以及这些子类型之间的关系。我们的研究将使临床医生能够更好地评估和个体化治疗并将指导未来的 POTS 研究。