NHGRI/DIR Scientific Computing

NHGRI/DIR 科学计算

• 批准号: 10691167
• 负责人: Andreas Baxevanis
• 金额: $ 293.14万
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10691167
• 关键词: Archives; Behavioral Research; Bioinformatics; Biological; Biometry; Clinical; Clinical Protocols; Clinical Research; Computer Systems; Computer software; DNA Sequence; Data; Data Analyses; Databases; Development; Diagnosis; Environment; Genetic Diseases; Genetic Research; Genomics; Health Insurance Portability and Accountability Act; Hereditary Disease; High Performance Computing; Human Genetics; Information Systems; Intramural Research; Laboratories; Memory; National Human Genome Research Institute; Online Systems; Pathway Analysis; Prevention; Protein Sequence Analysis; Public Domains; Research; Research Personnel; Resources; Running; Scientist; Sequence Analysis; Structure; Translating; Translational Research; United States National Institutes of Health; Variant; clinical center; clinical database; computer infrastructure; computerized tools; computing resources; data visualization; data warehouse; detection method; genetic pedigree; genome sequencing; genome wide association study; genome-wide analysis; genomic data; high end computer; innovation; molecular modeling; programs; query tools; scientific computing; single cell analysis; terabyte; whole genome

The NHGRI Division of Intramural Research maintains a robust computational infrastructure for specialized research computing. These resources are provided to support the Division's broad program of genomic, bioinformatic, clinical, and behavioral research aimed at translating genomic and genetic research into a greater understanding of human genetic disease, as well as towards developing better methods for the detection, prevention, and treatment of heritable and genetic disorders. NHGRI/DIR maintains several high-end computer systems to support state-of-the-art computational sequence analysis, structure analysis, data visualization, and similar memory-intensive scientific computing requirements. The Division also provides significant computational support for its high-throughput research efforts in whole-genome sequencing, whole-genome association studies, clinical variant discovery, and similar types of genome-wide analyses. These approaches generate enormous amounts of data (on the order of terabytes) in a single run, thereby requiring strong database solutions, innovative storage and archiving strategies, and a reliable high-performance computing environment, one that can keep pace with the ever-increasing rate at which large-scale biological and biomedical data are being generated. NHGRI/DIR maintains an extensive suite of commercial and public domain software for handling the wide range of needs of NHGRI investigators. The list includes software for DNA and protein sequence analysis, molecular modeling, expression analysis (including single-cell analysis), pathway analysis, biostatistics, and the analysis of data being generated by whole-genome association studies. In addition, realizing the importance of providing NHGRI scientists with a robust database in support of their clinical research efforts, a Web-based and HIPAA-compliant database with an integrated pedigree viewer and SQL querying tool is made available to all NHGRI investigators conducting clinical protocols aimed at understanding the underlying mechanisms of a wide variety of human genetic disorders. This clinical database's functionality allows for the automated import of clinical laboratory data from the NIH Clinical Center's Clinical Research Information System (CRIS) data warehouse and from NIH's Biomedical Translation Research Information System (BTRIS).

壁内研究的NHGRI部门为专门研究计算的强大计算基础架构保持了强大的计算基础架构。提供这些资源是为了支持该部门的广泛基因组，生物信息，临床和行为研究，旨在将基因组和遗传学研究转化为对人类遗传疾病的更多了解，以及开发更好的检测，预防和治疗可遗传和遗传疾病的方法。 NHGRI/DIR维护了几个高端计算机系统，以支持最新的计算序列分析，结构分析，数据可视化和类似的记忆密集型科学计算要求。该部门还为其在全基因组测序，全基因组关联研究，临床变异发现和类似类型的全基因组分析的高通量研究工作中提供了重要的计算支持。这些方法在一次运行中产生了大量的数据（按trabytes的顺序），从而需要强大的数据库解决方案，创新的存储和归档策略以及一个可靠的高性能计算环境，可以使大型生物学和生物系统数据生成的可靠速度与不断增长的速率保持同步。 NHGRI/DIR保留了一套广泛的商业和公共领域软件，用于处理NHGRI调查人员的广泛需求。该列表包括用于DNA和蛋白质序列分析的软件，分子建模，表达分析（包括单细胞分析），途径分析，生物统计学以及全基因组关联研究生成的数据分析。此外，实现为NHGRI科学家提供强大数据库的重要性，以支持他们的临床研究工作，这是一个基于网络和HIPAA兼容的数据库，并提供了一个集成的谱系查看器和SQL查询工具，并可以为所有NHGRI调查人员提供旨在了解基本机制种类繁多的种族歧视机构的NHGRI研究人员。该临床数据库的功能允许从NIH临床中心的临床研究信息系统（CRIS）数据仓库和NIH的生物医学翻译研究信息系统（BTRIS）自动进口临床实验室数据。