NHGRI/DIR Scientific Computing

NHGRI/DIR 科学计算

基本信息

批准号：
8350238
负责人：
Andreas Baxevanis
金额：
$ 94.56万
依托单位：
NATIONAL HUMAN GENOME RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8350238
关键词：
Archives Behavioral Research Bioinformatics Biometry Clinical Clinical Protocols Clinical Research Computer Systems Computer software DNA Sequence Data Data Analyses Databases Detection Development Diagnosis Environment Genetic Research Genomics Health Insurance Portability and Accountability Act Hereditary Disease High Performance Computing Human Genetics Information Systems Intramural Research Laboratories Memory Methods Microarray Analysis Molecular Models National Human Genome Research Institute Online Systems Pathway Analysis Prevention Protein Sequence Analysis Public Domains Research Research Infrastructure Research Personnel Resources Running Scientist Sequence Analysis Solutions Structure Translating United States National Institutes of Health computer infrastructure computerized tools computing resources genetic pedigree genome sequencing genome wide association study genome-wide high end computer innovation molecular modeling next generation programs scientific computing tool

项目摘要

The NHGRI Division of Intramural Research maintains a robust computational infrastructure for specialized research computing. These resources are provided to support the Division's broad program of genomic, bioinformatic, clinical, and behavioral research aimed at translating genomic and genetic research into a greater understanding of human genetic disease, as well as towards developing better methods for the detection, prevention and treatment of heritable and genetic disorders. NHGRI/DIR maintains several high-end computer systems to support state-of-the-art computational sequence analysis, structure analysis, and similar memory-intensive scientific computing. The Division also provides significant computational resources in support of its high-throughput research efforts in whole-genome sequencing, whole-genome association studies, and similar types of genome-wide analyses. We continue to place particular emphasis on the infrastructure required to store and analyze "next-generation" sequencing data. These approaches generate enormous amounts of data (on the order of terabytes) in a single run, thereby requiring strong database solutions, innovative storage and archiving strategies, and a reliable high-performance computing environment. NHGRI/DIR maintains an extensive suite of commercial and public domain software for handling the wide range of needs of NHGRI investigators. The list includes software for DNA and protein sequence analysis, molecular modeling, microarray analysis, pathway analysis, biostatistics, and the analysis of data being generated by whole-genome association studies. In addition, realizing the importance of providing NHGRI scientists with a first-rate database for clinical research, a Web-based and HIPAA-compliant database with an integrated pedigree viewer and SQL querying tool is made available to all NHGRI investigators conducting clinical protocols aimed at understanding the underlying mechanisms of a wide variety of human genetic disorders. This clinical databases functionality allows for the automated import of clinical laboratory data from the NIH Clinical Center's Clinical Research Information System (CRIS) database.

壁内研究的NHGRI部门为专门研究计算的强大计算基础架构保持了强大的计算基础架构。提供这些资源是为了支持该部门的广泛基因组，生物信息，临床和行为研究，旨在将基因组和遗传研究转化为对人类遗传疾病的更多了解，以及开发更好的检测，预防和治疗可遗传和遗传疾病的方法。 NHGRI/DIR维护了几个高端计算机系统，以支持最新的计算序列分析，结构分析和类似的记忆密集型科学计算。该部门还提供了重要的计算资源，以支持其全基因组测序，全基因组协会研究和类似全基因组分析的高通量研究工作。我们继续特别强调存储和分析“下一代”测序数据所需的基础架构。这些方法在一次运行中产生了大量的数据（按trabytes的顺序），从而需要强大的数据库解决方案，创新的存储和归档策略以及可靠的高性能计算环境。 NHGRI/DIR保留了一套广泛的商业和公共领域软件，用于处理NHGRI调查人员的广泛需求。该列表包括用于DNA和蛋白质序列分析的软件，分子建模，微阵列分析，途径分析，生物统计学以及全基因组关联研究生成的数据分析。此外，意识到为NHGRI科学家提供临床研究的一流数据库，这是一个基于Web且HIPAA兼容的数据库，并提供了一个集成的谱系查看器和SQL查询工具的重要性，所有NHGRI调查人员都可以使用旨在理解人类种植体属于人类种植体的基本机制的所有NHGRI调查人员进行。该临床数据库功能允许从NIH临床中心的临床研究信息系统（CRIS）数据库自动进口临床实验室数据。