A Mentoring Program in Patient-Oriented Tobacco Dependence and Implementation Science Research

以患者为导向的烟草依赖和实施科学研究的指导计划

• 批准号: 10700361
• 负责人: Robert A Schnoll
• 金额: $ 19.75万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700361
• 关键词: Address; Appointment; Area; Award; Biological Markers; Cancer Center; Cancer Patient; Cardiology; Caring; Cessation of life; Clinical; Communicable Diseases; Dedications; Dissemination and Implementation; Educational process of instructing; Educational workshop; Effectiveness; Electronic Health Record; Ensure; Evidence based treatment; Extramural Activities; Faculty; Funding; Goals; Grant; HIV; Health; Hospitalization; Individual; Inpatients; Intention; Malignant Neoplasms; Mentors; Mentorship; Metabolism; Methods; N-octanoylglucosylamine; Neurology; Nicotine; Nicotine Dependence; Oncology; Paper; Patients; Pennsylvania; Pharmaceutical Preparations; Pilot Projects; Pragmatic clinical trial; Primary Care; Productivity; Publications; Research; Research Personnel; Research Project Grants; Science; Scientist; Smoker; Smoking; Structure; Students; Testing; Time; Tobacco; Tobacco Dependence; Tobacco smoking behavior; Tobacco use; Training; Training Programs; Treatment Effectiveness; Underrepresented Minority; United States National Institutes of Health; Universities; Wages; Washington; Work; behavior test; behavioral economics; cancer care; care delivery; career; career development; clinical care; clinical practice; design; genetic testing; implementation research; implementation science; implementation strategy; improved; next generation; nicotine treatment; nicotine use; patient oriented; patient oriented research; personalized approach; personalized medicine; pilot test; premature; programs; recruit; reduce tobacco use; student mentoring; symposium; tobacco control; varenicline; working group

Despite progress over the past 50 years in lowering the rate of smoking, tobacco use remains the leading cause of premature death in the US. To ensure the sustained and impactful research dedicated to addressing tobacco use, rigorous inter-disciplinary mentoring programs are needed to prepare the next generation of researchers committed to patient-oriented research (POR) in this area. I have led a successful research program focused on testing methods to improve the use and effectiveness of treatments for tobacco for 21 years. For the first cycle of my K24, my primary mentorship goal was to train in mentorship and to formalize and enhance the mentoring activities that I had been engaged in from 2001-2017 into a structured, consistent, and comprehensive mentoring program in tobacco POR for students, fellows, and junior faculty. With K24 support over the past 4 years, I provided training to 21 new mentees, yielding 50 papers with mentees and 7 papers under review or in revision (>230 total by mentees) and 32 grants, including 5 Ks and 11 R01s, 3 as a New Investigator PI, compared to 25 mentees, 34 publications with mentees, and 2 Ks and 2 R01s in the preceding 17 years. For the first cycle of the K24, my primary research goal was to augment my tobacco POR by building expertise in implementation science through training and by pilot testing use of the nicotine metabolite ratio (NMR) – a genetically-informed biomarker of nicotine metabolism rate – for personalizing tobacco treatment as an implementation strategy to increase use of tobacco treatments. K24 support over the past 4 years, led to six new grants in tobacco and implementation science, 4 focused on testing the NMR in clinical practice: HIV care, primary care, and in-patients (R01 CA243914; U54 GM104941; P50 CA244690; R01 HG012670; SAP#4100083101; R01 DA056050). I leveraged this research in implementation science to augment my mentoring by serving as faculty on two national implementation science training programs – NCI's Training Institute for Dissemination and Implementation Research in Cancer and Washington University at St. Louis's Institute for Implementation Science Scholars – and by serving as co-chair for the Cancer Center Cessation Initiative's Implementation Science Working Group. In this renewal, I will: 1) sustain the mentoring program in tobacco and implementation science POR that I established with the first K24 cycle, using a structured, comprehensive, and individualized approach for an additional 15 mentees; and 2) augment our tobacco and implementation science POR by conducting a pilot study to develop messages informed by behavioral economics for HIV+ patients and infectious disease clinicians that are related to intention to refer for (clinician) or engage with (patient) tobacco use treatment and then test the impact of these messages integrated into the electronic health record as implementation science strategies to increase actual referral for and engagement in tobacco treatment in the HIV clinical setting. This renewal will ensure that I continue to provide the mentoring needed to build the next generation of scientists to address tobacco use and to continue to grow my impactful research in tobacco control and implementation science.

尽管过去50年来降低吸烟率，但烟草使用仍然是主要原因 在美国过早死亡。确保致力于解决烟草的持续和有影响力的研究 需要使用严格的跨学科心理计划来准备下一代研究人员 致力于该领域的以患者为导向的研究（POR）。我领导了一项关注的成功研究计划 测试方法可以提高烟草治疗的使用和有效性21年。在第一个周期 在我的K24中，我的主要精神制目标是训练Mentalship并形式化和增强心理 我从2001 - 2017年从事的活动进行了结构化，一致且全面的心理 为学生，研究员和初级教师提供烟草POR的课程。在过去的四年中，我有了K24的支持，我 为21个新月经提供了培训，分发了50篇文章，并在审查或修订中提供7篇论文 （麦内斯总共> 230个）和32个赠款，包括5 k和11 r01s，3个作为新的研究员PI，而25 Menees，34个带有Menees的出版物，并在前17年中2 KS和2 R01。对于第一个周期 K24，我的主要研究目标是通过建立实施专业知识来增加我的烟草。 通过培训和试验测试使用尼古丁代谢物比（NMR）的科学 - 一种通用的信息 尼古丁代谢率的生物标志物 - 个性化烟草治疗作为实施策略 增加烟草治疗的使用。 K24在过去4年中的支持，导致烟草和 实施科学，4重点是在临床实践中测试NMR：艾滋病毒护理，初级保健和患者 （R01 CA243914; U54 GM104941; P50 CA244690; R01 HG012670; SAP＃4100083101; R01 DA056050）。我 利用这项研究在实施科学方面通过担任两个国家的教师来增强我的心理 实施科学培训计划 - NCI传播和实施培训研究所 圣路易斯实施科学学者研究所的癌症和华盛顿大学研究 - 并担任癌症中心戒烟计划的实施科学工作组的联合主席。 在此续约中，我将：1）我在烟草和实施科学中维持心理计划 使用第一个K24周期建立，使用结构化，全面和个性化的方法 另外15个梅内斯； 2）通过进行飞行员来增强我们的烟草和实施科学。 研究为艾滋病毒+患者和传染病临床医生提供行为经济学告知的信息 与参考（临床医生）或（患者）烟草使用治疗的意图有关的意图有关 这些信息作为实施科学策略纳入电子健康记录的影响 在HIV临床环境中增加实际推荐和参与烟草治疗。这个更新的意愿 确保我继续提供建立下一代科学家所需的心理 烟草使用并继续在烟草控制和实施科学方面发展我有影响力的研究。

项目成果

Evaluation of nicotine patch adherence measurement using self-report and saliva cotinine among abstainers in a smoking cessation trial.

在戒烟试验中，使用自我报告和唾液可替宁对戒烟者的尼古丁贴片依从性测量进行评估。

• DOI: 10.1016/j.drugalcdep.2020.107967
• 发表时间: 2020
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Schnoll,Robert;PaulWileyto,E;Gross,Robert;Hitsman,Brian;HawkJr,LarryW;Cinciripini,Paul;George,TonyP;Benowitz,NealL;FenLubitz,Su;Ashare,Rebecca;Tyndale,RachelF;Lerman,Caryn
• 通讯作者: Lerman,Caryn

Assessing barriers to providing tobacco use disorder treatment in community mental health settings with a revised version of the Smoking Knowledge, Attitudes, and Practices (S-KAP) instrument.

• DOI: 10.1016/j.addbeh.2020.106735
• 发表时间: 2021-03
• 期刊: Addictive behaviors
• 影响因子: 4.4
• 作者: Siegel SD;Laurenceau JP;Hill N;Bauer AM;Flitter A;Ziedonis D;Stevens N;Hosie Quinn M;Leone F;Beidas R;Kimberly J;Schnoll RA
• 通讯作者: Schnoll RA

The use of biomarkers to guide precision treatment for tobacco use.

使用生物标志物指导烟草使用的精准治疗。

• DOI: 10.1016/j.addicn.2023.100076
• 发表时间: 2023
• 期刊: Addiction neuroscience
• 作者: Siegel,ScottD;Tindle,HilaryA;Bergen,AndrewW;Tyndale,RachelF;Schnoll,Robert
• 通讯作者: Schnoll,Robert

Speeding implementation in cancer: The National Cancer Institute's Implementation Science Centers in Cancer Control.

加速癌症的实施：国家癌症研究所的癌症控制实施科学中心。

• DOI: 10.1093/jnci/djac198
• 发表时间: 2023
• 期刊: Journal of the National Cancer Institute
• 作者: Oh,AprilY;Emmons,KarenM;Brownson,RossC;Glasgow,RussellE;Foley,KristieL;Lewis,CaraC;Schnoll,Robert;Huguet,Nathalie;Caplon,Amy;Chambers,DavidA
• 通讯作者: Chambers,DavidA

Rationale and protocol for a cluster randomized pragmatic clinical trial testing behavioral economic implementation strategies to improve tobacco treatment rates for cancer patients who smoke.

• DOI: 10.1186/s13012-021-01139-7
• 发表时间: 2021-07-15
• 期刊: Implementation science : IS
• 作者: Jenssen BP;Schnoll R;Beidas R;Bekelman J;Bauer AM;Scott C;Evers-Casey S;Nicoloso J;Gabriel P;Asch DA;Buttenheim A;Chen J;Melo J;Shulman LN;Clifton ABW;Lieberman A;Salam T;Zentgraf K;Rendle KA;Chaiyachati K;Shelton R;Wileyto EP;Ware S;Leone F
• 通讯作者: Leone F