A Patient-Oriented Research Mentoring Program in Tobacco Dependence Research

烟草依赖性研究中以患者为导向的研究指导计划

• 批准号: 10094212
• 负责人: Robert A Schnoll
• 金额: $ 18.7万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10094212
• 关键词: Address; Adult; Advisory Committees; Advocacy; Advocate; Area; Award; Behavioral; Biological Markers; Cancer Center; Caring; Data; Educational process of instructing; Educational workshop; Effectiveness; Electronic Health Record; Employment; Ensure; Evaluation; Faculty; Fostering; Funding; Goals; Grant; Individual; Industry; Leadership; Link; Medical; Mentors; Mentorship; Metabolic Clearance Rate; Methods; Modeling; National Institute of Drug Abuse; Nicotine; Nicotine Dependence; Paper; Patient Recruitments; Patients; Peer Review; Pharmaceutical Preparations; Physicians; Pilot Projects; Positioning Attribute; Primary Care Physician; Primary Health Care; Productivity; Professional counselor; Public Health; Publications; Research; Research Personnel; Research Project Grants; Role; Safety; Schools; Science; Scientist; Secure; Services; Shapes; Smoker; Smoking; Structure; Students; Testing; Time; Tobacco Dependence; Tobacco smoking behavior; Tobacco use; Traineeship; Training; Training Programs; Translational Research; Treatment Effectiveness; United States National Institutes of Health; Universities; Use Effectiveness; Work; Writing; base; career; career development; experience; implementation science; improved; next generation; nicotine treatment; nicotine use; patient oriented; patient oriented research; personalized medicine; preventable death; programs; recruit; role model; skills; student mentoring; symposium; teacher; training opportunity

Despite great progress over the past 50 years in reducing the rate of smoking, tobacco dependence remains a leading public health concern in the US. To ensure the sustained and impactful research effort dedicated to addressing tobacco dependence, rigorous and inter-disciplinary mentoring programs are needed to prepare the next generation of researchers committed to tobacco dependence patient-oriented research (POR). I have led a successful research program focused on the evaluation of methods to improve the use and effectiveness of treatments for nicotine dependence for ~20 years and, during this time, I have mentored 24 students, fellows, or junior faculty. This Mid-Career Investigator Award will be used to support 2 overarching career goals. First, to support my primary mentorship career goal, I will formalize and enhance the mentoring activities that I have been engaged in since 2001 into a structured, comprehensive, and impactful mentoring program in tobacco dependence POR for students, fellows, and junior faculty. This will involve: 1) the implementation of a formal mentoring framework for trainees with different academic levels, which will double the number of mentees vs. the past 5 years and markedly increase mentoring productivity and impact in terms of publications and grants; 2) strengthening a pipeline for mentee recruitment through new mechanisms such as T32s and TCORS; and 3) the recruitment and mentoring of 6 students, 4 fellows, and 3 junior faculty over the next 5 years, in addition to 5 current mentees (for a total of 18). My mentoring program will use NIDA's mentoring framework, and will: 1) focus on students and junior faculty to ensure that training begins early in a mentee's career; 2) provide individualized training based on mentee's goals and abilities; 3) provide short/intensive and long/sustained traineeships depending on the mentee; 4) offer training in inter-disciplinary science; and 5) offer intensive training in patient-oriented research (POR). To facilitate my career development, I will: 1) use a Mentoring Advisory Committee, comprised of faculty experienced with mentoring, 2) complete courses, conferences, and workshops in translational and implementation science and mentoring and leadership; and 3) join a Penn effort to enhance links between behavioral and primary care. Second, to support my primary research career goal, I will broaden my POR program to include translational and implementation science through a pilot study of the use of the nicotine metabolite ratio (NMR) for promoting clinician prescribing and patient use of treatments for nicotine dependence within primary care. Based on our work showing that personalizing nicotine dependence treatment using the NMR improves treatment effectiveness and safety, the pilot will assess the translational potential of this model within primary care, while providing opportunities for mentee training and facilitating a subsequent R01. This mid-career investigator award will markedly improve my past mentoring record, offer new opportunities for mentoring and career development, and enable the expansion of my POR program to include translational and implementation science.

尽管在过去50年中降低吸烟率方面取得了巨大进展，但烟草依赖仍然是 在美国领先的公共卫生问题。确保致力于 需要解决烟草依赖，需要严格和跨学科的指导计划来准备 下一代研究人员致力于烟草依赖患者的研究（POR）。我有 领导了一项成功的研究计划，重点是评估方法，以提高使用和有效性 尼古丁依赖的治疗方法约20年，在此期间，我指导了24名学生 研究员或初级教师。该中期研究员奖将用于支持2个总体职业 目标。首先，为了支持我的主要指导职业目标，我将正式化并增强指导 自2001年以来，我从事的活动从事结构化，全面和有影响力的指导 为学生，研究员和初级教师提供烟草依赖的计划。这将涉及：1） 为具有不同学术水平的学员实施正式的指导框架，这将两倍 受训者的数量与过去5年的数量，并显着提高了指导的生产率和影响 出版物和赠款； 2）通过新机制加强招募人员招募的管道 作为T32和TCOR； 3）招募和指导6名学生，4名研究员和3名初级教师 接下来的5年，除了5名当前受训者（总计18个）。我的指导计划将使用NIDA的 指导框架，并将：1）专注于学生和初级教师，以确保培训在早期开始 受训者的职业； 2）根据受训者的目标和能力提供个性化的培训； 3）提供 根据受训者的不同，短/密集和长期/持续的训练； 4）提供跨学科的培训 科学; 5）提供针对患者的研究（POR）的深入培训。为了促进我的职业发展， 我将：1）使用指导咨询委员会，由经验丰富的教师组成，2） 翻译和实施科学和指导的课程，会议和研讨会 领导; 3）加入Penn努力，以增强行为和初级保健之间的联系。第二，支持 我的主要研究职业目标，我将扩大我的POR计划，包括翻译和实施 科学通过对尼古丁代谢物比（NMR）促进临床医生的使用的试验研究 在初级保健中开处方和患者使用治疗尼古丁依赖性的治疗方法。根据我们的工作 表明使用NMR个性化尼古丁依赖治疗可以提高治疗效果 和安全性，飞行员将评估该模型在初级保健中的转化潜力，同时提供 训练和促进随后的R01的机会。这个职业中期调查员奖将 明显改善我过去的指导记录，为指导和职业发展提供新的机会， 并使我的POR计划的扩展包括转化和实施科学。