Center for Leadership in Environmental Awareness and Research

环境意识和研究领导力中心

• 批准号: 10700797
• 负责人: Carol Jean Miller
• 金额: $ 223.62万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700797
• 关键词: Address; Adverse effects; Affect; Aging; Awareness; Bayesian Modeling; Behavioral; Benzene; Biological; Biological Assay; Biological Markers; Biomedical Research; Birth; Birth Rate; Businesses; Chemicals; Child Health; Cities; Collaborations; Communication; Communities; Complex; Computing Methodologies; Country; Data; Data Analyses; Dedications; Detection; Development; Documentation; Education; Engineering; Ensure; Environmental Engineering technology; Environmental Health; Environmental Impact; Environmental Pollution; Environmental Science; Epidemiologic Methods; Etiology; Exposure to; Faculty; Fetal health; Gases; Great Lakes Region; Hazardous Substances; Health; Health system; Home; Human; Immune; Immunologics; Industrialization; Inflammation; Inflammatory Response; Infrastructure; Institution; Internet of Things; Intervention; Knowledge; Laboratories; Leadership; Life; Link; Maps; Maternal Health; Methodology; Methods; Michigan; Minority Groups; Modeling; Neurologic; Outcome; Participant; Pathway interactions; Phase; Placenta; Plants; Play; Predisposition; Pregnancy Outcome; Premature Birth; Property; Public Health; Reporting; Research; Research Activity; Research Project Grants; Risk; Risk Assessment; Role; Sampling; Schools; Science; Scientist; Site; Soil; Specimen; Superfund; System; Targeted Research; Techniques; Technology; Testing; Tetrachloroethylene; Time; Tissues; Toluene; Toxic effect; Toxicant exposure; Training; Translating; Translational Research; Translations; Trichloroethylene; Universities; Visualization software; Workplace; Xylene; Zebrafish; adverse birth outcomes; biological systems; built environment; college; community engagement; cost; data management; design; ethylbenzene; experience; exposed human population; exposure pathway; exposure route; ground water; improved; innovation; landfill; model organism; mouse model; next generation; novel; offspring; pollutant; pregnant; prevent; programs; public health emergency; public health intervention; real time model; remediation; reproductive; research and development; residence; response; risk mitigation; seal; sensor technology; superfund site; urban area; urban setting; vapor; vapor intrusion; volatile organic compound

Abstract: Evidence suggests that exposure to volatile organic compounds (VOCs), such as benzene, toluene, ethylbenzene, and xylene (BTEX), trichloroethylene (TCE), and tetrachloroethylene (PCE), is an important determinant of maternal-offspring health, with implications for preterm birth (PTB) and associated adverse health outcomes. VOCs emanate from landfills, brownfields, and Superfund sites, contaminating shallow soils and groundwater below residential, commercial, and industrial properties, leading to exposures via vapor intrusion. The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem with a focus on post-industrial urban centers. Headquartered in Detroit, Michigan, CLEAR will use Detroit as a study site, which has the highest PTB rate in the country (15.2%) and is located in a state where 37 of the 67 Superfund sites must manage VOC contamination. CLEAR hypothesizes that VOC exposure through vapor intrusion during early life incites inflammatory responses in maternal tissues and/or the developing offspring that re-program the developing immune and other critical systems, setting the stage for PTB and/or associated adverse health outcomes. Five integrative environmental science and engineering and biomedical research projects (E1, E2, B1, B2, B3), supported by five cores, will investigate toxic mechanisms, exposure pathways, biomarkers, and strategies to prevent exposures and improve public health outcomes by: (1) developing and testing new detection methodologies, including phytoscreening (E1); sensor technology that integrates Internet of Things and edge computing for real-time contaminant detection and rapid-response, mitigation, and remediation (E2); and a controlled toxicity bioassay using WSU-designed sealed chambers for evaluating reproductive, neurological, behavioral, immunological and multigenerational responses in zebrafish (B1); (2) studying mechanistic effects of VOC exposure in a pregnant mouse model (B2); (3) applying epidemiologic methods for estimating exposure effects via human biological specimen analysis (B3); applying advanced chemical analysis, statistical approaches and visualization tools to obtain and integrate project data (Chemical Analysis, and Data Management and Analysis Cores), thereby establishing the impact of VOC exposures on PTB and associated adverse health outcomes; (4) creating an innovative model for transdisciplinary education and workforce diversity by engaging new trainees to solve complex environmental health problems (Research Experience and Training Coordination Core); (5) engaging stakeholders and the community to inform our inquiry/analysis, participate in sampling, and employ health interventions (Community Engagement Core); and (6) uniting around an Administrative Core that conducts targeted research translation to ensure a legacy of scientific awareness and supports the Superfund Research Program to improve public health in urban centers impacted by environmental contamination to protect affected communities.

摘要：有证据表明，接触挥发性有机化合物（VOC），如苯、甲苯、 乙苯、二甲苯（BTEX）、三氯乙烯（TCE）和四氯乙烯（PCE）是重要的 母子健康的决定因素，对早产（PTB）和相关不良影响有影响 健康结果。挥发性有机化合物来自垃圾填埋场、棕地和超级基金场地，污染浅层土壤 以及住宅、商业和工业地产下方的地下水，导致通过蒸气暴露 入侵。环境意识与研究领导力中心 (CLEAR) 致力于 了解并缓解这一严重的环境健康问题，重点关注后工业城市 中心。总部位于密歇根州底特律的 CLEAR 将使用 PTB 最高的底特律作为研究地点 该国的比率 (15.2%)，并且位于 67 个超级基金站点中有 37 个必须管理 VOC 的州 污染。 CLEAR 假设生命早期通过蒸汽侵入接触 VOC 会引发 母体组织和/或发育中的后代中的炎症反应会重新编程发育中的后代 免疫系统和其他关键系统，为 PTB 和/或相关不良健康结果奠定基础。五 环境科学与工程与生物医学综合研究项目（E1、E2、B1、B2、B3）、 由五个核心支持，将研究毒性机制、暴露途径、生物标志物和策略 通过以下方式预防暴露并改善公共卫生结果：(1) 开发和测试新的检测方法 方法，包括植物筛选（E1）；物联网与边缘融合的传感器技术 用于实时污染物检测和快速响应、缓解和修复的计算（E2）；和一个 使用 WSU 设计的密封室进行受控毒性生物测定，用于评估生殖、神经、 斑马鱼的行为、免疫和多代反应（B1）； (2)研究机械效应 怀孕小鼠模型中 VOC 暴露的影响 (B2)； (3)应用流行病学方法进行估算 通过人体生物样本分析得出的暴露影响（B3）；应用先进的化学分析、统计 获取和集成项目数据（化学分析和数据）的方法和可视化工具 管理和分析核心），从而确定 VOC 暴露对 PTB 和相关的影响 不良健康后果； （4）创建跨学科教育和劳动力的创新模式 通过让新学员解决复杂的环境健康问题来实现多样性（研究经验 和培训协调核心）； (5) 让利益相关者和社区参与我们的调查/分析， 参与采样并采取健康干预措施（社区参与核心）； (6) 团结 围绕一个行政核心进行有针对性的研究翻译，以确保科学遗产 意识并支持超级基金研究计划，以改善受影响城市中心的公共卫生 通过环境污染来保护受影响的社区。

项目成果

Loss of flavin-containing monooxygenase 3 modulates dioxin-like polychlorinated biphenyl 126-induced oxidative stress and hepatotoxicity.

• DOI: 10.1016/j.envres.2024.118492
• 发表时间: 2024-02
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Manisha Agarwal;Katherine Roth;Zhao Yang;Rahul Sharma;Krishnarao Maddipati;Judy Westrick;M. Petriell