Chemical Analysis Core

化学分析核心

• 批准号: 10700831
• 负责人: PAUL M STEMMER
• 金额: $ 6.85万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700831
• 关键词: Address; Air; Animal Model; Awareness; Biological; Biological Assay; Biomedical Research; Chemicals; Chronic; Cities; Data Science; Dedications; Detection; Discipline; Disease; Dose; Educational workshop; Emerging Technologies; Ensure; Environmental Engineering technology; Environmental Exposure; Environmental Health; Evaluation; Experimental Designs; Exposure to; Geographic Locations; Health; Human; Immunoassay; Industrialization; Inflammation; Inflammation Mediators; Informatics; Knowledge; Laboratory Personnel; Laboratory Research; Leadership; Mass Spectrum Analysis; Measurement; Measures; Methods; Microfluidics; Mission; Molecular; Monitor; Outcome; Pathway interactions; Peptides; Persons; Physiological; Post-Translational Protein Processing; Postdoctoral Fellow; Premature Birth; Preparation; Property; Protein Analysis; Proteins; Proteome; Proteomics; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Science; Services; Soil; Superfund; System; Techniques; Technology; Testing; Time; Toxic effect; Training; Uncertainty; Volatilization; Work; adduct; analytical method; biomarker discovery; biomarker identification; cohort; community engagement; cost; cytokine; design; experimental study; exposed human population; graduate student; ground water; high throughput analysis; innovation; instrument; instrumentation; monitoring device; multidisciplinary; new technology; next generation; novel; novel strategies; offspring; pollutant; population based; residence; response; sensor; small molecule; urban area; vapor intrusion; volatile organic compound

SUMMARY/ABSTRACT: Exposure to volatile organic compounds (VOCs) is an important determinant of maternal-offspring health, with implications for preterm birth and associated adverse health outcomes. VOCs contaminate shallow soils and groundwater of post-industrial cities at Superfund, residential, commercial, and industrial properties, leading to exposure via vapor intrusion. The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem. The Chemical Analysis Core (CAC) will create a comprehensive toolbox to quantitate, monitor, and determine the extent of VOC exposure for CLEAR research projects and the Community Engagement Core (CEC). The CAC supports CLEAR’s mission by providing analytical knowledge, guidance, training and new technologies designed to detect, assess and mitigate the adverse health effects emanating from chronic and low-level exposure to VOCs. The CAC leadership and laboratory personnel will work with and within the CLEAR project teams to ensure sensitive, accurate analyses and develop advanced techniques for VOC analysis in novel matrices as required. Specifically, the CAC will offer precise, sensitive, low cost, high volume quantification of VOC molecules and their metabolites, which are known or suspected to impact health. Proteomic and adductomic analyses will identify markers of environmental exposures as well as the extent of disease. Targeted and untargeted VOC analyses, proteomic, and adductomic workflows, which are available to investigators through partnership with the CAC, is tailored for each of the five CLEAR projects and the CEC. For each, analytical quantification of unique samples and new innovative sample preparation methods are an expected outcome. The CAC integrates small molecule mass spectrometry, proteomic mass spectrometry and high throughput cytokine analysis. These complementary analytical technologies enable the CAC to be integrated into CLEAR research projects and facilitate assessment of the degree of exposure and VOC exposure impacts on human health.

摘要/摘要：暴露于挥发性有机化合物 (VOC) 是一个重要的决定因素。 母子健康，对早产和相关不良健康结果的影响。 污染超级基金、住宅、商业和后工业城市的浅层土壤和地下水 工业特性，导致蒸汽侵入导致暴露。 意识与研究 (CLEAR) 致力于了解和缓解这一严重的环境问题 化学分析核心（CAC）将创建一个全面的工具箱来定量、监测、 并确定 CLEAR 研究项目和社区参与的 VOC 暴露程度 核心 (CEC)。CAC 通过提供分析知识、指导、培训和支持来支持 CLEAR 的使命。 旨在检测、评估和减轻慢性病对健康造成的不利影响的新技术 CAC 领导层和实验室人员将与 CAC 合作并在其内部工作。 CLEAR 项目团队确保对 VOC 进行灵敏、准确的分析并开发先进技术 具体来说，CAC 将提供精确、灵敏、低成本、高产量的分析。 已知或怀疑会影响健康的 VOC 分子及其代谢物的量化。 蛋白质组学和内合组学分析将识别环境暴露的标记以及环境暴露的程度 靶向和非靶向 VOC 分析、蛋白质组学和内含物组学工作流程，可用于 调查员与 CAC 合作，为五个 CLEAR 项目和 CEC 量身定制。 对于每种样品，独特样品的分析定量和新的创新样品制备方法都是重要的 CAC 整合了小分子质谱、蛋白质组质谱和 这些互补的分析技术使 CAC 能够进行高通量细胞因子分析。 融入 CLEAR 研究项目并促进暴露程度和 VOC 的评估 暴露对人体健康的影响。