Chemical Analysis Core

化学分析核心

• 批准号: 10700831
• 负责人: PAUL M STEMMER
• 金额: $ 6.85万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700831
• 关键词: Address; Air; Animal Model; Awareness; Biological; Biological Assay; Biomedical Research; Chemicals; Chronic; Cities; Data Science; Dedications; Detection; Discipline; Disease; Dose; Educational workshop; Emerging Technologies; Ensure; Environmental Engineering technology; Environmental Exposure; Environmental Health; Evaluation; Experimental Designs; Exposure to; Geographic Locations; Health; Human; Immunoassay; Industrialization; Inflammation; Inflammation Mediators; Informatics; Knowledge; Laboratory Personnel; Laboratory Research; Leadership; Mass Spectrum Analysis; Measurement; Measures; Methods; Microfluidics; Mission; Molecular; Monitor; Outcome; Pathway interactions; Peptides; Persons; Physiological; Post-Translational Protein Processing; Postdoctoral Fellow; Premature Birth; Preparation; Property; Protein Analysis; Proteins; Proteome; Proteomics; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Science; Services; Soil; Superfund; System; Techniques; Technology; Testing; Time; Toxic effect; Training; Uncertainty; Volatilization; Work; adduct; analytical method; biomarker discovery; biomarker identification; cohort; community engagement; cost; cytokine; design; experimental study; exposed human population; graduate student; ground water; high throughput analysis; innovation; instrument; instrumentation; monitoring device; multidisciplinary; new technology; next generation; novel; novel strategies; offspring; pollutant; population based; residence; response; sensor; small molecule; urban area; vapor intrusion; volatile organic compound

SUMMARY/ABSTRACT: Exposure to volatile organic compounds (VOCs) is an important determinant of maternal-offspring health, with implications for preterm birth and associated adverse health outcomes. VOCs contaminate shallow soils and groundwater of post-industrial cities at Superfund, residential, commercial, and industrial properties, leading to exposure via vapor intrusion. The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem. The Chemical Analysis Core (CAC) will create a comprehensive toolbox to quantitate, monitor, and determine the extent of VOC exposure for CLEAR research projects and the Community Engagement Core (CEC). The CAC supports CLEAR’s mission by providing analytical knowledge, guidance, training and new technologies designed to detect, assess and mitigate the adverse health effects emanating from chronic and low-level exposure to VOCs. The CAC leadership and laboratory personnel will work with and within the CLEAR project teams to ensure sensitive, accurate analyses and develop advanced techniques for VOC analysis in novel matrices as required. Specifically, the CAC will offer precise, sensitive, low cost, high volume quantification of VOC molecules and their metabolites, which are known or suspected to impact health. Proteomic and adductomic analyses will identify markers of environmental exposures as well as the extent of disease. Targeted and untargeted VOC analyses, proteomic, and adductomic workflows, which are available to investigators through partnership with the CAC, is tailored for each of the five CLEAR projects and the CEC. For each, analytical quantification of unique samples and new innovative sample preparation methods are an expected outcome. The CAC integrates small molecule mass spectrometry, proteomic mass spectrometry and high throughput cytokine analysis. These complementary analytical technologies enable the CAC to be integrated into CLEAR research projects and facilitate assessment of the degree of exposure and VOC exposure impacts on human health.

摘要/摘要：暴露于挥发性有机化合物（VOC）是重要的确定 孕产妇的健康状况，对早产和相关的不良健康结果有影响。 VOC 超级基金，居民，商业和 工业特性，导致通过蒸气侵入暴露。环境领导中心 意识和研究（清晰）致力于理解和缓解这种严重的环境 健康问题。化学分析核心（CAC）将创建一个综合的工具箱来定量，监视， 并确定清晰研究项目和社区参与的VOC暴露程度 核心（CEC）。 CAC通过提供分析知识，指导，培训以及 新技术旨在检测，评估和减轻慢性的不良健康影响 和低水平接触VOC。 CAC领导和实验室人员将与 清除项目团队，以确保敏感，准确的分析并为VOC开发高级技术 根据需要进行新型矩阵分析。具体而言，CAC将提供精确，敏感，低成本，大容量 VOC分子及其代谢产物的量化，这些分子已知或怀疑会影响健康。 蛋白质组学和辅助分析将确定环境暴露的标记以及 疾病。有针对性和无靶的VOC分析，蛋白质组学和辅助工作流，可用于 通过与CAC的合作伙伴关系的调查人员是针对五个清晰项目和CEC量身定制的。 对于每种，独特样本的分析量和新的创新样品制备方法是一种 预期结果。 CAC整合了小分子质谱法，蛋白质组学质谱和 高通量细胞因子分析。这些完整的分析技术使CAC成为 集成到清晰的研究项目中，并促进对暴露程度和VOC的评估 接触对人类健康的影响。