Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development

产前压力和化学品暴露对儿童发育的累积影响

基本信息

批准号：
10685822
负责人：
Susan L Schantz
金额：
$ 13.57万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10685822
关键词：
Achievement Address Attention Benzophenones Biological Markers Birth Birth Weight Blood California Chemical Exposure Chemicals Child Development Child Health Childhood Chronic Chronic stress Cognitive Collection Complex Corticotropin-Releasing Hormone Data Data Analyses Data Collection Data Set Development Endocrine Disruptors Environmental Exposure Environmental Policy Etiology Exposure to Geography Gestational Age Green space Hair Household Illinois Impaired cognition Individual Infant Interdisciplinary Study Intervention Joints Length Leukocytes Life Measurement Measures Mediating Methodology Mothers Neighborhoods Neonatal Outcome Parabens Participant Perception Phenols Plasma Poly-fluoroalkyl substances Pregnancy Pregnancy Histories Pregnant Women Production Protocols documentation Psychosocial Stress Research San Francisco Shapes Short-Term Memory Social Perception Social Policies Social status Socioeconomic Status Source Standardization Stress Structure of nail of toe Triclosan Umbilical Cord Blood Umbilical cord structure Unit of Measure Universities Urine adverse birth outcomes adverse pregnancy outcome base biological adaptation to stress built environment cognitive development cognitive function cohort data harmonization data management early childhood ethnic diversity experience fetal human data human tissue indexing infancy information processing innovation maternal stress neurodevelopment novel novel strategies offspring postnatal prenatal prenatal exposure prenatal stress professional atmosphere programs racial diversity recruit resilience response biomarker social cognition social stress social stressor socioeconomics stress resilience telomere triclocarban

项目摘要

PROJECT SUMMARY We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of high- production volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which research suggests may impact development, but for which data on child health outcomes is sparse: phenols (bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual - perceptions of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based – neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3) Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone (CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we will use innovative approaches to assess basic cognitive functions including working memory, attention, information processing, and social cognition in infancy and early childhood. We will address three specific aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of prenatal stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual and place-based stress and developmental outcomes. (3) Evaluate whether maternal stress modifies observed relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of offspring. During the planning period, we will harmonize data collection and management (including biospecimens, stress measurements, and measurements of birth outcomes and cognitive functions) across our two cohorts to prepare for merging our two data sets and for sharing our data with the ECHO Data Analysis Center. During UG3 stage we will also actively participate in development and implementation of the ECHO-wide study protocol contributing expertise and methodology for assessing maternal stress, offspring cognitive development and our experiences integrating and harmonizing data collection across our two geographically distinct pregnancy cohorts. In summary, our innovative research approach will contribute to ECHO by providing a framework for integrating cumulative chemical exposures with chronic psychosocial stress and sources of resilience in order to understand the complex set of prenatal etiologic factors that shape developmental outcomes in infancy and early childhood.

项目摘要我们建议在伊利诺伊大学和加利福尼亚大学旧金山（UCSF）在社会，种族和种族上，种族和种族多样性的队列（echo.ca.il）研究化学暴露和母体的累积影响对出生结果和早期神经发育的社会心理压力。我们将专注于两组高级生产量内分泌破坏化学物质（EDC）在孕妇中经常检测到研究表明可能会影响发展，但是关于儿童健康结果的数据很少：苯酚（双苯酚，苯甲酮，二氯苯甲酚，对羟基苯甲酸酯，三氯生，三氯甘兰）和全氟烷基物质（PFA）。我们将测量三个慢性压力和弹性的指标：1）感知 - 感知家庭，邻里和工作环境中的社会地位和压力暴露； 2）基于地点的 - 社区层面的社会经济地位，公民参与，绿色空间和建筑环境； 3）生物标志物 - 母体和脐带白细胞的端粒长度和皮质激素释放（CRH）MATER血浆中的水平。我们将衡量出生结果（出生体重和胎龄），我们将使用创新方法来评估基本认知功能，包括工作记忆，注意力，信息处理以及婴儿期和幼儿期的社会认知。我们将解决三个特定的目的：（1）评估产前暴露与EDC与不良出生措施之间的关系后代的结果和认知发展。（2）评估措施之间的关系产前压力和不良出生结果和后代认知发展的度量。重要的是，为此，我们还将评估压力反应的生物标志物是否介导关系在基于感知的压力和发展结果之间。（3）评估是否有母亲压力改变了观察到的EDC暴露与不良出生的度量之间的关系后代的结果或认知发展。在计划期间，我们将协调数据收集和管理（包括生物测量，压力测量和分娩的测量值结果和认知功能）遍及我们两个同类，以准备合并我们的两个数据集和与回声数据分析中心共享我们的数据。在UG3阶段，我们还将积极参与回声范围的研究协议的开发和实施贡献了专业知识和方法论评估遗产压力，后代认知发展以及我们的经验整合和协调在我们两个地理上不同的怀孕人群中收集数据。总而言之，我们的创新研究方法将通过提供将累积化学暴露与与慢性社会心理压力和弹性来源，以了解复杂的产前集合塑造婴儿期和幼儿期发育结果的病因学因素。