ECHO Supplement

回声补充

• 批准号: 10412797
• 负责人: Susan L Schantz
• 金额: $ 33.34万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412797
• 关键词: Address; Attention; Benzophenones; Biological Markers; Birth; Birth Weight; California; Chemical Exposure; Chemicals; Child Health; Chronic; Chronic stress; Complex; Corticotropin-Releasing Hormone; Data; Data Analyses; Data Collection; Data Set; Development; Endocrine Disruptors; Environmental Policy; Etiology; Exposure to; Geography; Gestational Age; Green space; Household; Illinois; Intervention; Length; Leukocytes; Measurement; Measures; Mediating; Methodology; Mothers; Neighborhoods; Outcome; Parabens; Phenols; Plasma; Poly-fluoroalkyl substances; Pregnancy; Pregnant Women; Production; Protocols documentation; Psychosocial Stress; Research; San Francisco; Shapes; Short-Term Memory; Social Perception; Social Policies; Social status; Socioeconomic Status; Source; Stress; Triclosan; Umbilical cord structure; Universities; adverse birth outcomes; base; biological adaptation to stress; built environment; cognitive development; cognitive function; cohort; data harmonization; data management; early childhood; ethnic diversity; experience; indexing; infancy; information processing; innovation; maternal stress; neurodevelopment; offspring; prenatal; prenatal exposure; prenatal stress; professional atmosphere; racial diversity; recruit; resilience; social cognition; social stress; social stressor; socioeconomics; stress resilience; telomere; triclocarban

Project Summary We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of high production volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which research suggests may impact development, but for which data on child health outcomes is sparse: phenols (bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual – perceptions of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based – neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3) Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone (CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we will use innovative approaches to assess basic cognitive functions including working memory, attention, information processing, and social cognition in infancy and early childhood. We will address three specific aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of prenatal stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual and place-based stress and developmental outcomes. (3) Evaluate whether maternal stress modifies observed relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of offspring. During the planning period, we will harmonize data collection and management (including biospecimens, stress measurements, and measurements of birth outcomes and cognitive functions) across our two cohorts to prepare for merging our two data sets and for sharing our data with the ECHO Data Analysis Center. During UG3 stage we will also actively participate in development and implementation of the ECHO-wide study protocol contributing expertise and methodology for assessing maternal stress, offspring cognitive development and our experiences integrating and harmonizing data collection across our two geographically distinct pregnancy cohorts. In summary, our innovative research approach will contribute to ECHO by providing a framework for integrating cumulative chemical exposures with chronic psychosocial stress and sources of resilience in order to understand the complex set of prenatal etiologic factors that shape developmental outcomes in infancy and early childhood.

项目摘要 我们建议在伊利诺伊大学和 加利福尼亚大学旧金山（UCSF）在社会，种族和种族上，种族和 种族多样性的队列（echo.ca.il）研究化学暴露和母体的累积影响 对出生结果和早期神经发育的社会心理压力。我们将专注于两组高 生产量内分泌破坏化学物质（EDC）在孕妇中经常检测到 研究表明可能会影响发展，但是关于儿童健康结果的数据很少：苯酚 （双苯酚，苯甲酮，二氯苯甲酚，对羟基苯甲酸酯，三氯生，三氯甘兰）和全氟烷基 物质（PFA）。我们将测量三个慢性压力和韧性指数：1）感知 - 感知 家庭，邻里和工作环境中的社会地位和压力暴露； 2）基于地点的 - 社区层面的社会经济地位，公民参与，绿色空间和建筑环境； 3） 生物标志物 - 母体和脐带白细胞的端粒长度和皮质激素释放 （CRH）MATER血浆中的水平。我们将衡量出生结果（出生体重和胎龄），我们将 使用创新方法评估基本认知功能，包括工作记忆，注意力，信息 加工和婴儿期和幼儿期的社会认知。我们将解决三个具体目标：（1） 评估产前暴露于EDC的关系和不良出生结果的度量 和后代的认知发展。 （2）评估产前度量之间的关系 压力和不利的出生结果和后代认知发展的措施。重要的是，是 这个目标我们还将评估压力反应的生物标志物是否介导感知之间的关系 以及基于场所的压力和发展成果。 （3）评估材料应力修饰符是否 观察到的EDC暴露与不良出生结果或认知措施之间的关系 后代的发展。在计划期间，我们将协调数据收集和管理 （包括生物测量，应力测量以及对出生结果和认知功能的测量） 在我们的两个队列中，准备合并我们的两个数据集并与回声数据共享我们的数据 分析中心。在UG3阶段，我们还将积极参与开发和实施 回声范围的研究方案贡献了评估母校压力，后代的专业知识和方法论 认知发展和我们的经验，整合和协调了我们两者的数据收集 地理上不同的怀孕人群。总而言之，我们的创新研究方法将有助于 通过提供将累积化学暴露与慢性社会心理压力整合的框架来回声 和弹性的来源，以了解形成的复杂产前病因学因素集 婴儿期和幼儿期的发展结果。