Organophosphate flame retardants exposure during pregnancy, maternal thyroid hormone disruption and early infant cognition

怀孕期间接触有机磷阻燃剂、母体甲状腺激素破坏和婴儿早期认知

基本信息

批准号：
10177664
负责人：
Susan L Schantz
金额：
$ 11.27万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10177664
关键词：
Address Age Age-Months Animals Attention Award Benzophenones Biological Biological Markers Birth Birth Weight California Chemical Exposure Chemicals Child Child Health Chronic Chronic stress Cognition Cognitive Complex Consumption Corticotropin-Releasing Hormone Data Data Analyses Data Collection Data Set Decision Making Development Endocrine Disruptors Environmental Epidemiology Etiology Exposure to Fetal Growth Flame Retardants Funding Geography Gestational Age Goals Grant Green space Health Household Human Illinois Individual Infant Infant Development Intake Knowledge Latina Length Leukocytes Linear Regressions Link Location Measurement Measures Mediating Mediation Mentorship Methodology Methods Micronutrients Minerals Modeling Neighborhoods Nurses Organophosphates Outcome Paired Comparison Parabens Parents Participant Pathway interactions Pattern Perinatal Phenols Plasma Poly-fluoroalkyl substances Positioning Attribute Pregnancy Pregnant Women Protocols documentation Psychosocial Stress Research Research Personnel Research Project Grants San Francisco Scientific Advances and Accomplishments Scientist Serum Shapes Short-Term Memory Social Perception Social status Socioeconomic Status Source Statistical Methods Stress Structure Technology Thyroid Function Tests Thyroid Hormones Thyrotropin Thyroxine Training Translational Research Triclosan Triiodothyronine Umbilical cord structure Universities Visual Visual attention Vitamins Woman Writing adverse birth outcomes aged base biological adaptation to stress built environment career clinical practice cognitive development cognitive function cohort data harmonization data management early childhood environmental chemical exposure ethnic diversity experience improved indexing infancy information processing innovation maternal stress mother nutrition multidisciplinary neurodevelopment novel offspring prenatal prenatal exposure prenatal stress professional atmosphere racial diversity recruit reproductive resilience skills social cognition social stress socioeconomics stress resilience telomere thyroid disruption triclocarban urinary virtual visual tracking

Address Age Age-Months Animals Attention Award Benzophenones Biological Biological Markers Birth Birth Weight California Chemical Exposure Chemicals Child Child Health Chronic Chronic stress Cognition Cognitive Complex Consumption Corticotropin-Releasing Hormone Data Data Analyses Data Collection Data Set Decision Making Development Endocrine Disruptors Environmental Epidemiology Etiology Exposure to Fetal Growth Flame Retardants Funding Geography Gestational Age Goals Grant Green space Health Household Human Illinois Individual Infant Infant Development Intake Knowledge Latina Length Leukocytes Linear Regressions Link Location Measurement Measures Mediating Mediation Mentorship Methodology Methods Micronutrients Minerals Modeling Neighborhoods Nurses Organophosphates Outcome Paired Comparison Parabens Parents Participant Pathway interactions Pattern Perinatal Phenols Plasma Poly-fluoroalkyl substances Positioning Attribute Pregnancy Pregnant Women Protocols documentation Psychosocial Stress Research Research Personnel Research Project Grants San Francisco Scientific Advances and Accomplishments Scientist Serum Shapes Short-Term Memory Social Perception Social status Socioeconomic Status Source Statistical Methods Stress Structure Technology Thyroid Function Tests Thyroid Hormones Thyrotropin Thyroxine Training Translational Research Triclosan Triiodothyronine Umbilical cord structure Universities Visual Visual attention Vitamins Woman Writing adverse birth outcomes aged base biological adaptation to stress built environment career clinical practice cognitive development cognitive function cohort data harmonization data management early childhood environmental chemical exposure ethnic diversity experience improved indexing infancy information processing innovation maternal stress mother nutrition multidisciplinary neurodevelopment novel offspring prenatal prenatal exposure prenatal stress professional atmosphere racial diversity recruit reproductive resilience skills social cognition social stress socioeconomics stress resilience telomere thyroid disruption triclocarban urinary virtual visual tracking

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项目摘要

PROJECT SUMMARY – Parent UH3 OD023272 We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of highproduction volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which research suggests may impact development, but for which data on child health outcomes is sparse: phenols (bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual - perceptions of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based – neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3) Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone (CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we will use innovative approaches to assess basic cognitive functions including working memory, attention, information processing, and social cognition in infancy and early childhood. We will address three specific aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of prenatal stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual and place-based stress and developmental outcomes. (3) Evaluate whether maternal stress modifies observed relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of offspring. During the planning period, we will harmonize data collection and management (including biospecimens, stress measurements, and measurements of birth outcomes and cognitive functions) across our two cohorts to prepare for merging our two data sets and for sharing our data with the ECHO Data Analysis Center. During UG3 stage we will also actively participate in development and implementation of the ECHO- wide study protocol contributing expertise and methodology for assessing maternal stress, offspring cognitive development and our experiences integrating and harmonizing data collection across our two geographically distinct pregnancy cohorts. In summary, our innovative research approach will contribute to ECHO by providing a framework for integrating cumulative chemical exposures with chronic psychosocial stress and sources of resilience in order to understand the complex set of prenatal etiologic factors that shape developmental outcomes in infancy and early childhood.

项目摘要 - 家长UH3 OD023272 我们建议在伊利诺伊大学和加利福尼亚大学旧金山（UCSF）在社会，种族和种族上，种族和种族多样性的队列（echo.ca.il）研究化学暴露和母体的累积影响对出生结果和早期神经发育的社会心理压力。我们将专注于两组大量生产量内分泌破坏化学物质（EDC），在孕妇中经常检测到，这些化学物质（EDC）研究表明可能会影响发展，但是关于儿童健康结果的数据很少：苯酚（双苯酚，苯甲酮，二氯苯甲酚，对羟基苯甲酸酯，三氯生，三氯甘兰）和全氟烷基物质（PFA）。我们将测量三个慢性压力和弹性的指标：1）感知 - 感知家庭，邻里和工作环境中的社会地位和压力暴露； 2）基于地点的 - 社区层面的社会经济地位，公民参与，绿色空间和建筑环境； 3）生物标志物 - 母体和脐带白细胞的端粒长度和皮质激素释放（CRH）MATER血浆中的水平。我们将衡量出生结果（出生体重和胎龄），我们将使用创新方法来评估基本认知功能，包括工作记忆，注意力，信息处理以及婴儿期和幼儿期的社会认知。我们将解决三个特定的目的：（1）评估产前暴露与EDC与不良出生措施之间的关系后代的结果和认知发展。（2）评估产前度量之间的关系压力和不利的出生结果和后代认知发展的措施。重要的是，为此目的我们还将评估压力反应的生物标志物是否介导感知之间的关系以及基于场所的压力和发展成果。（3）评估材料应力是否修改了观察到的 EDC暴露与不良出生结果的度量或认知发展之间的关系后代。在计划期间，我们将协调数据收集和管理（包括我们的生物测量，压力测量和分娩结果和认知功能的测量）两个队列准备合并我们的两个数据集并与ECHO数据分析共享我们的数据中心。在UG3阶段，我们还将积极参与回声的发展和实施广泛的研究方案贡献了评估母校压力，后代认知的专业知识和方法论开发以及我们在两个地理上整合和协调数据收集的经验独特的怀孕队列。总而言之，我们的创新研究方法将通过提供对Echo的贡献将累积化学暴露与慢性社会心理压力和来源集成的框架弹性，以了解塑造发展的复杂产前病因学因素婴儿期和幼儿的结果。