Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Multisite Resource and Coordinating Center

促进母亲和儿童心血管健康的早期干预 (ENRICH) 多站点资源和协调中心

• 批准号: 10685009
• 负责人: LISA A COOPER
• 金额: $ 17.56万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-05 至 2029-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685009
• 关键词: Address; Applied Research; Caring; Child; Clinical Trials; Communities; Data; Discipline of Nursing; Early Intervention; Effectiveness; Effectiveness of Interventions; Emerging Technologies; Enrollment; Ethnic Origin; Family; Generations; Geography; Heterogeneity; Home visitation; Individual; Infant; Infrastructure; Intervention; Knowledge; Leadership; Life Cycle Stages; Maternal Mortality; Mediator of activation protein; Medicine; Methods; Modeling; Morbidity - disease rate; Mothers; Outcome; Policies; Protocols documentation; Public Health; Reduce health disparities; Research; Research Design; Research Personnel; Resources; Risk; Risk Factors; Services; Socioeconomic Status; Testing; Time; Training; Translating; Translations; United States; Work; cardiovascular health; clinical center; design; evidence base; health disparity; health equity; health of the mother; improved; innovation; mHealth; maternal morbidity; mortality; multidisciplinary; programs; racial disparity; success; telehealth

Poor cardiovascular health (CVH) contributes to high levels of morbidity and mortality in the United States, with profound health disparities by race/ethnicity, socioeconomic status, and geography. Sustained improvement in CVH requires 2-generation strategies in settings where those at elevated risk for poor CVH already receive care. Evidence-based home visiting (HV) provides an ideal setting to reduce health disparities, reduce maternal morbidity, and promote CVH in infants and children in ways that can be continued across the life course. Prior studies of CVH intervention effectiveness have not tested interventions across HV models, incorporated emerging technologies such as mHealth and telehealth, combined HV with services in other settings where mothers and children receive care, acknowledged mediators and moderators of effectiveness, nor used individual and composite maternal and child CVH metrics to assess outcomes. The Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) program aims to address these limitations. It will test a common implementation-ready intervention to promote maternal and child CVH and reduce CVH disparities in the context of multiple evidence-based HV models. The success of ENRICH requires a Resource and Coordinating Center (RCC) with sophisticated content and methods expertise and resources to support study design and implementation of a common intervention and research protocol attuned to heterogeneity in individual, family, and community context. The Johns Hopkins RCC multidisciplinary team combines the expertise of the Home Visiting Applied Research Collaborative (HARC), the Johns Hopkins Center for Clinical Trials and Evidence Synthesis (CCTES) and the Johns Hopkins Center for Health Equity. This RCC team offers an unparalleled combination of a national HV platform, expertise in health equity, and clinical trials infrastructure to create new management strategies, organization concepts and impactful analyses to assure that ENRICH achieves its potential. Our RCC includes: (1) stakeholder-built HV Precision Paradigm; (2) content expertise and leadership in HV and CVH; (3) state of the art methods to design and implement a common protocol, analyze data, disseminate results, and translate for policy and practice (4) advanced methods to assess “What works best, for whom, in which contexts, why and how?” and assess ideal CVH metrics for both mothers and children; (5) tight linkage with HV and CVH stakeholders; and (6) expertise in engaging and training Early Stage Investigators and HV staff professionals. The RCC will apply the strengths of three JHU divisions (Public Health, Medicine and Nursing) to ENRICH to generate impactful evidence on effectiveness of the ENRICH intervention and powerful data on generalizability to enhance translation. The RCC will assure that ENRICH achieves its full potential and generates rigorous, innovative, timely and actionable new knowledge to reduce maternal morbidity, promote CVH and reduce CVH disparities in mothers and young children.

不良的心血管健康（CVH）在美国有助于高水平的发病率和死亡率 根据种族/种族，社会经济地位和地理的深刻健康分配。持续改进 CVH需要在CVH较差风险较高的环境中采用2代策略 关心。循证家庭访问（HV）提供了减少健康分配，减少健康分配的理想环境 孕产妇的发病率，并以可以在一生中继续的方式促进婴儿和儿童的CVH 课程。对CVH干预效果的先前研究尚未测试HV模型的干预措施， 合并了MHealth和Telehealth等新兴技术，将HV与其他服务相结合 母亲和儿童获得护理，公认的调解人和有效性的主持人的环境， 也不使用个人和复合材料以及儿童CVH指标来评估结果。早期干预 促进母亲和儿童的心血管健康（富集）计划旨在解决这些问题 限制。它将测试一项常见的实施干预措施，以促进母校和儿童CVH和 在多个基于证据的HV模型的背景下，减少CVH差异。丰富的成功需要 资源和协调中心（RCC），具有复杂的内容和方法专业知识和资源 支持研究设计和实施共同的干预和研究方案 个人，家庭和社区背景的异质性。约翰·霍普金斯RCC多学科团队 结合了家庭访问应用研究合作的专业知识（HARC），约翰·霍普金斯 临床试验与证据综合中心（CCTE）和约翰·霍普金斯卫生公平中心。 这个RCC团队提供了国家HV平台，健康公平专业知识和无与伦比的组合 临床试验基础设施以创建新的管理策略，组织概念和有影响力 分析以确保丰富其潜力。我们的RCC包括：（1）利益相关者建立的HV精度 范例; （2）HV和CVH的内容专业知识和领导； （3）设计和设计的状态 实施共同的协议，分析数据，分发结果并转化为政策和实践（4） 评估“什么最有效的方法，在哪些情况下，为什么，为什么以及如何？”和评估理想 母亲和儿童的CVH指标； （5）与HV和CVH利益相关者的紧密联系； （6）专业知识 参与和培训早期研究人员和HV员工专业人员。 RCC将应用 三个JHU部门（公共卫生，医学和护理）的优势丰富以产生影响力 关于丰富干预措施有效性的证据，以及有关加强性的强大数据 翻译。 RCC将假设Enrich发挥其全部潜力，并产生严格，创新的， 及时且可行的新知识，以减少母体发病率，促进CVH并减少CVH差异 在母亲和幼儿中。