The Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE)

大西洋中部心脏代谢健康公平中心 (MACCHE)

• 批准号: 10494167
• 负责人: LISA A COOPER
• 金额: $ 408.16万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494167
• 关键词: Address; Adult; Baltimore; Black race; Cardiometabolic Disease; Caring; Chronic; Chronic Disease; Chronic Kidney Failure; Clinical; Cluster randomized trial; Collaborations; Communities; Community Health Aides; Complex; Development; Diabetes Mellitus; Disease Management; Economics; Effectiveness; Fibrosis; Goals; Grant; Health; Health Policy; Heart Injuries; Heart failure; High Risk Woman; Home Blood Pressure Monitoring; Home visitation; Hypertension; Individual; Infrastructure; Institution; Intervention; Intervention Studies; Latinx; Leadership; Level of Evidence; Life Cycle Stages; Link; Maryland; Mentors; Morbidity - disease rate; Myocardial dysfunction; Obesity; Outcome; Outcomes Research; Ownership; Patient Recruitments; Patient-Focused Outcomes; Pharmacists; Phase; Pilot Projects; Policies; Postpartum Women; Pregnancy; Pregnant Women; Problem Solving; Provider; Public Health Practice; Quality of life; Research; Research Personnel; Risk Factors; Science; Services; Structure; Testing; Training; Translating; Translations; United States; Universities; base; blood pressure control; cardiometabolic risk; cardiometabolism; cardiorespiratory fitness; community based participatory research; community center; community engaged research; community engagement; compare effectiveness; comparison intervention; data harmonization; disadvantaged population; disease disparity; disorder prevention; effectiveness testing; ethnic disparity; evidence base; fitness; geographic disparity; health disparity; health equity; improved; innovation; low socioeconomic status; mortality; multidisciplinary; postpartum health; postpartum weight; programs; racial and ethnic; racial disparity; randomized trial; social disadvantage; socioeconomic disparity; telemonitoring; treatment as usual

OVERALL PROJECT SUMMARY The overarching goal of the Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE) is to test the effectiveness of comprehensive, integrated, and multi-level evidence-based strategies for improving cardiometabolic health outcomes among socially disadvantaged populations in Maryland, using community- based participatory research and patient-centered outcomes research principles, and translate them into clinical and public health practice and policy. We will leverage the existing infrastructure of the Johns Hopkins Center for Health Equity, which has applied a comprehensive approach to health equity for over 10 years, a partnership with the University of Maryland Baltimore, and collaborations with Morgan State University and other institutions in the region. MACCHE will include 3 separate, but related intervention studies addressing disparities in cardiometabolic disease; 3 integrated cores (Administrative, Investigator Development, and Community Engagement); an Executive Committee; and a Community Advisory Board. Study 1 is a randomized trial comparing the effectiveness of an evidence-based pregnancy/postpartum health coaching/home visiting intervention to usual home visiting services in reducing postpartum weight retention among Black and Latinx women at high risk for cardiometabolic health disparities; Study 2 is a randomized trial examining the effectiveness of a multi-level intervention of problem-solving training, community health worker (CHW) support and partnership with community facilities for enhancing cardiorespiratory fitness in adults with low socioeconomic status, diabetes, obesity and asymptomatic cardiac dysfunction; and Study 3 is a cluster- randomized trial testing the effectiveness of a multi-level intervention linking self-monitored blood pressure (BP) with telemonitoring, team-based care with pharmacists and CHWs, and provider-level interventions compared to enhanced usual care, for improving BP control among socially disadvantaged adults with uncontrolled hypertension plus diabetes or chronic kidney disease. The Administrative Core will carry out the overall administration of the grant, providing infrastructure and support for data harmonization, management and analysis, patient recruitment and retention, and intervention adaptation and implementation. The Investigator Development Core will establish a pilot project program for early-stage investigators and create a mentoring network and community for pilot project awardees, to support innovative research related to chronic disease disparities. The Community Engagement Core will implement a shared governance structure to reinforce stakeholder leadership and ownership; advance, facilitate, and evaluate MACCHE’s community- engaged research and investigator development initiatives; and employ community-centered strategies to translate, disseminate, and sustain MACCHE initiatives. The MACCHE will advance the science of cardiometabolic disease disparities and facilitate its translation into clinical and public health practice and policy.

全面的 项目摘要 心脏代谢健康公平中心中心（MACCHE）的总体目标是测试 综合，综合和多层循证策略的有效性改善 马里兰州的社会困扰人口中的心脏代谢健康结果，使用社区 - 基于参与研究和以患者为中心的结果研究原则，并将其转化为 临床和公共卫生实践和政策。我们将利用约翰·霍普金斯的现有基础设施 卫生公平中心已将综合方法应用于卫生公平已有10多年，一个 与马里兰大学巴尔的摩大学合作，以及与摩根州立大学和 该地区的其他机构。 Macche将包括3个单独的，但相关的干预研究解决 心脏代谢疾病的差异； 3个综合核心（行政，调查员发展和 社区参与）；执行委员会；和社区顾问委员会。研究1是 随机试验比较循证妊娠/产后健康的有效性 教练/家庭访问干预措施，以减少产后保留率，以减少产后的家庭访问服务 在黑人和拉丁裔女性中，心脏代谢健康分布的高风险；研究2是一项随机试验 研究解决问题培训的多层次干预的有效性，社区卫生工作者 （CHW）与社区设施的支持和合作伙伴关系，以增强成人的心肺健康 社会经济状况低下，糖尿病，肥胖和不对称心脏功能障碍；研究3是一个集群 随机试验测试多层干预的有效性，将自我监测的血压连接起来 （BP）通过远程监控，与药剂师和CHW的基于团队的护理以及提供商级的干预措施 与增强的常规护理相比 不受控制的高血压加糖尿病或慢性肾脏疾病。行政核心将执行 赠款的总体管理，为数据协调提供基础架构和支持 以及分析，患者招募和保留以及干预适应和实施。 调查员开发核心将为早期研究人员建立试点项目计划，并创建一个 试点项目获奖者的心理网络和社区，以支持与慢性有关的创新研究 疾病分布。社区参与核心将实施共同的治理结构 增强利益相关者的领导和所有权；提前，设施和评估Macche的社区 - 参与研究和研究者开发计划；以及以社区为中心的策略 翻译，传播和维持MACCHE计划。 Macche将推进科学 心脏代谢疾病分布并促进其转化为临床和公共卫生实践， 政策。