Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core

临床确定、生物样本采集、数据管理和分析研究核心

• 批准号: 10675721
• 负责人: Tina V Hartert
• 金额: $ 37.51万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-04 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675721
• 关键词: 10 year old; 8 year old; Address; Age; Allergic Disease; Asthma; Biometry; Birth; Blood; Child; Childhood; Childhood Asthma; Clinic; Clinical; Clinical Management; Clinical Research; Collection; Core Assembly; DNA; Data; Data Analyses; Data Collection; Development; Discipline of obstetrics; Disease Outcome; Enrollment; Ensure; Environment; Epidemiologist; Epithelial Cells; Funding; Human; Hypersensitivity; Immune; Immunologist; Infant; Infection; Infrastructure; Intervention; Laboratories; Lung infections; Methodology; Neonatal; Nose; Pathway interactions; Peripheral Blood Mononuclear Cell; Persons; Phenotype; Physiological; Predisposition; Pregnancy; Process; Randomized; Research; Research Personnel; Resources; Respiratory Syncytial Virus Infections; Respiratory syncytial virus; Role; Sampling; Site; Specimen; Structure; Techniques; Testing; United States National Institutes of Health; Viral; Virus; Visit; Woman; acronyms; airway epithelium; clinical phenotype; cohort; data acquisition; data management; design; epidemiology study; experience; follow-up; human population study; infancy; multidimensional data; novel; recruit; respiratory morbidity; study population; synergism

CORE B ABSTRACT - Clinical Ascertainment, Retention and Biospecimen Acquisition Research Core The purpose of this core is to develop and support the two human birth cohorts which serve as the study populations to address fundamental questions about the role of respiratory syncytial virus (RSV) on childhood respiratory morbidity and asthma through scientific projects that focus on interactive pathways of the host and virus on asthma development (Project 1), and interventions that may modify immune and airway epithelial cell development through which RSV may cause asthma (Project 2). This clinical ascertainment, retention and biosample acquisition and management research core will serve to manage the two human study populations: Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure (INSPIRE) and Childhood Allergy and the Neonatal Environment (CANOE), and manage the resultant key biospecimens and data. Data acquisition will include careful phenotyping, RSV exposure assessment, physiologic testing, nasal airway epithelial cell (NAEC) collection, nasal brushings, blood and peripheral blood mononuclear cells (PBMCs), and DNA for Projects 1 and 2. This core is centered around the rich infrastructure at Vanderbilt and surrounding engaged pediatric and obstetrical clinics to conduct the clinical studies. This includes support for the recruitment, enrollment and retention of the birth cohorts, longitudinal follow-up, and the laboratory components of the biosample collection and processing. This core assembles a complementary research team of epidemiologists, virologists, immunologists, geneticists, biostatisticians, and research personnel experienced in cohort retention, and biospecimen acquisition and will provide the data and biospecimens to analytic Core C where data will be processed and biostatistical analyses will be conducted. This core is structured as two aims with each supporting one of the two cohorts. The first is to facilitate and oversee the longitudinal follow-up of the established INSPIRE birth cohort, biospecimen collection, including NAECs for Projects 1 and 2. The second is to facilitate and oversee recruitment, enrollment and longitudinal follow-up of the new CANOE birth cohort, and biospecimen collection, including NAECs for Projects 1 and 2.

核心B摘要 - 临床确定，保留和生物循环收购研究核心 该核心的目的是开发和支持两个人类的人群 研究人群解决了有关呼吸综合病毒（RSV）对的基本问题 儿童期通过科学项目的呼吸道发病和哮喘 哮喘发育中的宿主和病毒（项目1），以及可能改变免疫和气道的干预措施 RSV可能引起哮喘的上皮细胞发育（项目2）。这个临床确定， 保留和生物样品采集和管理研究核心将有助于管理两项人类研究 人群：RSV暴露后对肺部感染和哮喘的敏感性（INSPIRE）和 儿童过敏和新生儿环境（独木舟），并管理最终的关键生物测量和 数据。数据采集​​将包括仔细的表型，RSV暴露评估，生理测试，鼻音 气道上皮细胞（NAEC）收集，鼻刷，血液和外周血单核细胞 （PBMC）和项目1和2的DNA。 该核心集中在范德比尔特（Vanderbilt）和周围订婚儿科的富裕基础设施围绕 和产科诊所进行临床研究。这包括对招聘，入学和 保留出生队列，纵向随访和生物样品集合的实验室组件 和处理。该核心组成了一个互补的流行病学家，病毒学家， 免疫学家，遗传学家，生物统计学家和研究人员在队列保留方面经历过 生物测量的获取，并将为分析核心C提供数据和生物测量，其中数据将为数据 将进行处理和生物统计分析。该核心的结构为两个目标 支持两个队列之一。首先是促进和监督该纵向的随访 既定的Inspire出生队列，生物循环收集，包括项目1和2的NAEC。第二个是 促进和监督新独木舟出生队列的招聘，入学和纵向随访以及 Biospecimen Collection，包括项目1和2的NAEC。