ECHO Renewal for the CANOE Study Cohort

CANOE 研究队列的 ECHO 更新

• 批准号: 10745082
• 负责人: Tina V Hartert
• 金额: $ 132.05万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745082
• 关键词: 2 year old; Address; Age; Asthma; Biological Process; Biological Specimen Banks; Birth; Black Populations; Bronchiolitis; COVID-19 pandemic; Child; Child Health; Childhood; Childhood Acute Lymphocytic Leukemia; Childhood Asthma; Cohort Studies; Collection; Communities; Conceptions; Data; Data Element; Development; Diagnosis; Disease; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Epithelial Cells; Funding; Goals; Hispanic Populations; Hypersensitivity; Incidence; Individual; Infant; Infection; Infrastructure; Intervention; Licensure; Life; Medical History; Mentors; Modification; Monoclonal Antibodies; Neonatal; Nose; Outcome; Participant; Population; Predisposition; Pregnant Women; Prevention; Prevention strategy; Preventive; Primary Prevention; Protocols documentation; Public Health; Publications; Recommendation; Recurrence; Research; Research Personnel; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus Vaccines; Respiratory syncytial virus; Risk; Rural Community; Sampling; Severities; Southeastern United States; Testing; Urban Community; Vaccines; Wheezing; Work; age related; airway epithelium; asthma prevention; chronic respiratory disease; cohort; cost-effectiveness evaluation; design; disorder prevention; diversity and inclusion; early life exposure; ethnic diversity; expectation; follow-up; infancy; infant infection; innovation; interest; low and middle-income countries; middle childhood; multi-racial; novel; pandemic disease; pandemic impact; policy implication; pregnant; prevent; public health intervention; pulmonary function; racial diversity; recruit; resilience factor; respiratory microbiome; retention rate; vaccine acceptance

ABSTRACT The overarching goals of this application are to: 1) maintain retention of children in the Vanderbilt CANOE birth cohort with emphasis on diversity and implementation of the ECHO Cohort Protocol with high fidelity and conduct new enrollment, and 2) address key questions in the field about one of the most common and modifiable early life environmental exposures consistently associated with significantly increased asthma risk, respiratory syncytial virus (RSV) infection, delineating the severity-dependent and age-dependent effects of RSV infection on asthma risk. This innovative project has significant public health impact, as establishing the age- and severity-dependent relationship between RSV and asthma is the first and most important step in disease primary prevention. We propose to address key unanswered questions in the field: the severity- and age-dependent association of RSV and asthma, and the impact of infection on lung function. In addition, we will explore the broad impact of the SARS-CoV-2 pandemic on asthma incidence and control in an exploratory aim, which may provide support for multi-faceted environmental modifications in asthma prevention and control, and data to inform the potential impact of broad public health interventions. The birth cohort that this application supports is the Vanderbilt CANOE (Childhood Allergy and the NeOnatal Environment) study. CANOE is a birth cohort designed to identify and understand how environmental factors modify the development of the airway epithelium. The study includes the unique longitudinal sampling of the child airway throughout the first year of life, and annually. The Vanderbilt CANOE study has unique early life exposure and outcomes ascertainment, including surveillance for RSV and a novel biospecimen repository of nasal airway epithelial cells. The CANOE cohort also has important information for longitudinal development of the airway microbiome and the airway epithelium. The proposed research is innovative and timely given the anticipated licensure of multiple RSV prevention products in the coming year (maternal vaccines and long- acting monoclonal antibodies for infants). The proposed work represents a novel, multi-faceted approach to identifying and understanding the influence of severity of RSV infection and age of RSV infection on asthma risk and lung function. The answers to these questions will be critical to developing prevention strategies and informing public health expectations for RSV non-pharmaceutical preventive strategies and evaluating potential long-term value-added benefits of vaccines in preventing lifelong chronic respiratory disease. These data may not only bolster RSV vaccine acceptability and uptake in the US, but will almost certainly be useful in evaluating the cost-effectiveness of RSV prevention strategies in low and middle income countries.

抽象的 此应用的总体目标是：1）维持范德比尔特独木舟出生中的儿童保留 队列，重点是多样性和具有高忠诚的回声队列协议的实施 进行新的入学人数，2）解决该领域的关键问题，关于最常见的问题之一 可修改的早期生活环境暴露始终与哮喘风险显着增加相关， 呼吸道合胞病毒（RSV）感染，描述 RSV感染哮喘风险。这个创新的项目具有重大的公共卫生影响，因为 RSV和哮喘之间的年龄和严重程度依赖性关系是第一个也是最重要的一步 疾病初级预防。我们建议解决该领域的关键未解决问题：严重性和 RSV和哮喘的年龄依赖性关联，以及感染对肺功能的影响。另外，我们 将探讨SARS-COV-2大流行对探索性哮喘发病率和控制的广泛影响 AIM，这可能为预防哮喘的多方面环境修改提供支持 控制和数据为广泛的公共卫生干预措施的潜在影响。 该应用程序支持的出生队列是范德比尔特独木舟（儿童过敏和新生儿 环境）研究。独木舟是旨在识别和了解环境因素的出生队列 修改气道上皮的发展。该研究包括独特的纵向采样 儿童气道在生命的第一年，每年。范德比尔特独木舟研究具有独特的早期生活 暴露和结果确定，包括对RSV的监视和新型的生物测量存储库 鼻气道上皮细胞。独木舟队列还具有重要的信息，以进行纵向发展 气道微生物组和气道上皮。拟议的研究是创新的，并且及时 预期在来年获得多种RSV预防产品的许可（母疫苗和长期疫苗 对婴儿的作用单克隆抗体）。拟议的工作代表了一种新颖的，多方面的方法 识别和理解RSV感染严重程度和RSV感染年龄对哮喘的影响 风险和肺功能。这些问题的答案对于制定预防策略和 告知公共卫生对RSV非药物预防策略的期望并评估潜在 疫苗在预防终身慢性呼吸系统疾病方面的长期增值益处。这些数据可能 不仅在美国增强RSV疫苗的可接受性和吸收，而且几乎可以肯定会在 评估低收入国家和中等收入国家中RSV预防策略的成本效益。