Mentorship in Clinical Complementary and Integrative Health Research

临床补充和综合健康研究的指导

• 批准号: 10670137
• 负责人: Ryan D Bradley
• 金额: $ 15.52万
• 依托单位: NATIONAL UNIVERSITY OF NATURAL MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670137
• 关键词: Administrative Supplement; Adult; Applications Grants; Appointment; Award; Awareness; Biological; Biological Markers; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Competence; Complementary Health; Critical Pathways; Data; Dedications; Doctor of Philosophy; Environment; Epidemiologist; Exposure to; Funding; Future; Future Generations; Goals; Health; Industry; Integrative Medicine; International; Investments; K-Series Research Career Programs; Laboratories; Measurement; Mediator; Medical Research; Medicine; Mentors; Mentorship; Methodology; Methods; National Center for Complementary and Integrative Health; Natural Products; Oregon; Pacific Northwest; Pharmacy Schools; Phase I Clinical Trials; Phase II Clinical Trials; Population; Positioning Attribute; Postdoctoral Fellow; Publications; Qualifying; Request for Proposals; Research; Research Activity; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Safety; Sampling; Science; Scientist; Structure; Training; Training Activity; Training Programs; Translational Research; United States; United States National Institutes of Health; Universities; Washington; Work; career; career development; clinical care; clinical epidemiology; cohort; equity, diversity, and inclusion; experience; graduate student; improved; interest; mid-career faculty; post-doctoral training; programs; response; skills; transcription factor; translational physician; translational scientist

Because over 50% of adults in the United States take complementary and integrative health (CIH) natural products for their health, the training of CIH practitioners and scientists to produce high-quality clinical research is imperative to identifying effective products for the safety of the public. As such, this proposal requests a K24 mid-career development award to expand and support mentorship in clinical natural product research by Dr. Ryan Bradley, ND, MPH. Dr. Bradley has demonstrated effective mentorship by the publication of all past mentees, and the progression of multiple mentees from graduate students to formal NIH post-doctoral training awards, and independent training awards. Dr. Bradley is currently a Program Director and mentor in the NCCIH- funded T90/R90 Building Research across Interdisciplinary Gaps (BRIDG) clinical research training program formed in partnership between the University of Washington (UW) and the National University of Natural Medicine (NUNM). Dr. Bradley provides mentorship for 10 post-doctoral trainees, including CIH clinicians and PhD scientists. Dr. Bradley is a primary mentor for a T90 trainee who has progressed onto a KL2 award at the UW, a CIH practitioner who received a NICCH administrative supplement to gain research experience on Dr. Bradley's R01-funded clinical trials, and a T32 post-doctoral trainee in the ORCCAMIND T32 program at Oregon Health & Sciences University (for which Dr. Bradley is a formal mentor). In addition to his positions as Director of Research, Senior Investigator and Associate Professor at the NUNM, he retains affiliate and adjunct appointments at 3 US-based and 2 international universities, thus Dr. Bradley is extremely well connected to assist mentees in identifying resources and collaborators for their research. The Specific Aims of this proposal are for Dr. Bradley to: 1. Dedicate consistent effort in the mentorship of promising trainees in T32, T90, R90, and KL2 programs in order to facilitate their progression in research training and independent research (Aim 1); 2. Refine and develop mentoring skills by pursuing additional training in: mentorship; diversity, equity and inclusion in research; and cutting-edge translational science methodologies (Aim 2); and 3. Provide exposure to translational science methods and provide publication opportunities for mentees through the collection of additional preliminary data related to recent clinical trials of specialized pro-resolvin mediators (SPM) and xanthohumol natural products, including product quality assessment, measurement of relevant biomarkers in stored biologic samples, and measurement of additional transcription factors (PCSK9) to extend the research to new clinical populations (Aim 3).

因为超过 50% 的美国成年人服用补充和综合健康 (CIH) 天然药物 为他们的健康提供产品，培训 CIH 从业者和科学家进行高质量的临床研究 为公众安全确定有效的产品势在必行。因此，该提案要求 K24 职业中期发展奖，旨在扩大和支持 Dr. 临床天然产品研究的指导。 瑞安·布拉德利 (Ryan Bradley)，ND，公共卫生硕士。布拉德利博士通过出版所有过去的著作展示了有效的指导 受训者，以及多名受训者从研究生到正式 NIH 博士后培训的进展 奖和独立培训奖。 Bradley 博士目前是 NCCIH 的项目总监和导师 - 资助 T90/R90 跨学科差距建设研究 (BRIDG) 临床研究培训计划 华盛顿大学 (UW) 和国立自然大学合作成立 医学（NUNM）。 Bradley 博士为 10 名博士后实习生提供指导，其中包括 CIH 临床医生和 博士科学家。 Bradley 博士是一名 T90 学员的主要导师，该学员已在 华盛顿大学 (UW) 是一位 CIH 从业者，他获得了 NICCH 行政补助，以获得对 Dr. 的研究经验。 Bradley 的 R01 资助的临床试验，以及俄勒冈州 ORCCAMIND T32 项目的 T32 博士后实习生 健康与科学大学（布拉德利博士是该大学的正式导师）。除了担任董事职务外 NUNM 研究部高级研究员和副教授，他保留了附属机构和兼职人员 Bradley 博士曾在 3 所美国大学和 2 所国际大学任职，因此与 协助受训者确定其研究的资源和合作者。本提案的具体目标 Bradley 博士将： 1. 持续努力指导 T32、T90、R90 和 KL2 计划，以促进他们在研究培训和独立研究方面的进步（目标 1）； 2. 通过接受以下方面的额外培训来完善和发展指导技能：多样性、公平性和包容性 在研究中；和尖端的转化科学方法（目标 2）； 3. 提供接触 转化科学方法，并通过收集为学员提供出版机会 与最近专门的促分解素介质 (SPM) 临床试验相关的其他初步数据和 黄腐酚天然产品，包括产品质量评估、相关生物标志物的测定 存储的生物样本，以及额外转录因子 (PCSK9) 的测量，以将研究扩展到 新的临床人群（目标 3）。

项目成果

Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline.

• DOI: 10.3233/jad-230004
• 发表时间: 2023
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Sandison, Heather;Callan, Nini G. L.;Rao, Rammohan V.;Phipps, John;Bradley, Ryan
• 通讯作者: Bradley, Ryan