Investigating the longitudinal relationship between alcohol use, neurophysiological functioning, and Alzheimer disease biomarkers in the Collaborative Study on the Genetics of Alcoholism

在酒精中毒遗传学合作研究中调查饮酒、神经生理功能和阿尔茨海默病生物标志物之间的纵向关系

• 批准号: 10660983
• 负责人: Sarah Hartz
• 金额: $ 39.38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-20 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660983
• 关键词: Address; Adult; Affect; African American; Age; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Alleles; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid beta-Protein; Apolipoprotein E; Auditory; Blood Tests; Brain; Brain Pathology; Brain region; Clinical; Cognition; Communities; Complex; Data; Dementia; Demographic Factors; Development; Disease; Education; Elderly; Electroencephalography; Electrophysiology (science); Environmental Risk Factor; Evaluation; Event; Family; Funding; Genes; Genetic; Heavy Drinking; Impaired cognition; Knowledge; Light; Longitudinal Studies; Measurement; Measures; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neuropsychology; Onset of illness; Participant; Pattern; Phase; Plasma; Process; Psychopathology; Public Health; Research Personnel; Rest; Sampling; Semantics; Site; Span 20; Surveys; Testing; Visual; abeta deposition; age related; aging brain; alcohol effect; alcohol use disorder; cognitive task; comorbidity; demographics; design; drinking; genetic risk factor; genetics of alcoholism; high risk; imaging study; innovation; insight; member; mortality; neural; neural network; neuropathology; neurophysiology; neurotoxic; polygenic risk score; pre-clinical; protective factors; recruit; sample collection; structural imaging; substance use

Project Summary This is a study to investigate the relationship between trajectories of alcohol use, longitudinal changes in brain function, and the development of Alzheimer disease (AD). To address gaps in knowledge about the relationship between alcohol use and AD, we will integrate plasma Aβ testing and a measurement of clinical dementia into ongoing assessments of N=600 participants (age ≥ 50, 17% African American) in a large ongoing study of alcohol use disorder. We will leverage sample collection from the St. Louis site of the Collaborative Study on the Genetics of Alcoholism (COGA), a longitudinal, family-based study of alcohol use disorder funded by NIAAA for over 30 years, with extensive clinical, neuropsychological, electrophysiological, and genetic data from families densely affected by alcohol use disorder and community-based comparison families. The ongoing assessments of older COGA participants includes a comprehensive evaluation of alcohol use, neurophysiological measures including resting-state electroencephalogram (EEG) and event-related brain potentials (ERPs) acquired during cognitive tasks (same as in previous longitudinal assessments), and neuropsychological surveys. Together with existing COGA data, the new combined assessment will allow for creation of powerful measures of alcohol use, brain function, and neuropathology. This represents the first study to integrate AD biomarkers with comprehensive, longitudinal assessments of alcohol use. Aim 1 will examine the effect of alcohol consumption on preclinical AD and longitudinal changes in brain function and cognition in older adults. Aim 2 will investigate genetic, comorbid, environmental, and demographic factors as moderating the effect of alcohol consumption on AD biomarkers and brain function. The innovations include integration of state-of-the-art AD assessment, plasma biomarker of AD, brain function measures of neural synchronicity and connectivity, and comprehensive longitudinal assessment of alcohol use in a high-risk sample that has been followed over 20 years. This proposal is significant because the products and results will apply broadly to our understanding of both the development of AD and the long-term impact of alcohol on the brain.

项目摘要 这是一项研究，以研究酒精使用轨迹，大脑纵向变化之间的关系 功能，以及阿尔茨海默氏病（AD）的发展。解决有关知识的差距 酒精使用与AD之间的关系，我们将整合血浆Aβ测试和临床的测量 对n = 600名参与者（年龄≥50，17％非裔美国人）的痴呆症进行持续评估 正在进行的酒精使用障碍研究。我们将利用来自圣路易斯遗址的样本收集 关于酒精中毒遗传学（COGA）的合作研究，这是一项基于家庭的饮酒的纵向研究 由NIAAA资助的疾病已有30多年，具有广泛的临床，神经心理学，电生理学， 以及受酒精使用障碍和基于社区比较影响的家庭的遗传数据 家庭。对年长的COGA参与者的持续评估包括对酒精的全面评估 使用，包括静止状态脑电图（EEG）和事件相关的大脑在内的神经生理学措施 在认知任务（与以前的纵向评估相同）期间获得的电位（ERP），并且 神经心理学调查。与现有的COGA数据一起，新的合并评估将允许 创建对酒精使用，大脑功能和神经病理学的有力测量。 这是将AD生物标志物与全面的纵向评估相结合的首次研究 饮酒。 AIM 1将检查饮酒对临床前AD和纵向变化的影响 老年人的大脑功能和认知。 AIM 2将研究遗传，合并，环境和 人口统计学因素适度饮酒对AD生物标志物和大脑功能的影响。 创新包括整合最先进的广告评估，AD的等离子生物标志物，大脑功能 神经同步性和连通性的度量，以及对酒精使用的全面纵向评估 在20年以上的高风险样本中。该提议很重要，因为产品 结果将广泛地适用于我们对AD发展的理解和长期影响 大脑上酒精。