THE SHARED GENETICS OF ALCOHOL-RELATED DISORDERS AND SCHIZOPHRENIA

酒精相关疾病和精神分裂症的共同遗传学

• 批准号: 9243628
• 负责人: Sarah Hartz
• 金额: $ 19.5万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9243628
• 关键词: Address; African American; Alcohol consumption; Alcohol-Related Disorders; American; Area; Clinical; Comorbidity; DSM-V; Data; Diagnostic; Doctor of Philosophy; Etiology; European; General Population; Genetic; Heavy Drinking; Hereditary Disease; Individual; Lead; Mediation; Mental disorders; Methodology; Modeling; Nicotine Dependence; Prevalence; Psychiatrist; Public Health; Research; Research Personnel; Risk; Sampling; Schizophrenia; Smoking; Statistical Methods; Statistical Models; Structure; Substance Use Disorder; Tobacco Use Disorder; Variant; Work; alcohol use disorder; genetic analysis; genetic variant; genome wide association study; genome-wide; improved; novel; pleiotropism; post-doctoral training; severe mental illness; statistics

Abstract Severe mental illness and substance use disorder frequently co-occur. Individuals suffering from schizophrenia—a common, persistent, and severe mental illness—have much higher rates of heavy alcohol use and smoking than the general population. Similarly, individuals with substance use disorder often suffer from other mental illnesses. For example, 22% of individuals with alcohol use disorder have another mental illness, compared to 11% of individuals without alcohol use disorder. Despite the prevalence of comorbidity, it is not known whether shared genetic factors contribute to schizophrenia and substance use disorders. In this study, we use existing genome-wide association study (GWAS) data and state-of-the-art statistical methodology to evaluate whether schizophrenia shares genetic factors with alcohol use disorder or nicotine dependence. Specifically, in aim 1 we will evaluate whether genetic factors that contribute to schizophrenia also contribute to alcohol use disorder and to nicotine dependence. Then, in aim 2, we will evaluate whether genetic factors that contribute to either alcohol use disorder or nicotine dependence also contribute to schizophrenia. This novel proposal is significant because it will lead to improved understanding of comorbidity of schizophrenia with alcohol use disorder and with nicotine dependence at a genetic level.

抽象的 严重的精神疾病和药物使用障碍经常同时发生。遭受的个人 精神分裂症（一种常见，持久和严重的精神疾病）的重酒率要高得多 使用和吸烟比一般人群。同样，患有药物使用障碍的人经常受苦 来自其他精神疾病。例如，22％的酒精饮用障碍患者有另一种精神 疾病，相比之下，有11％的没有饮酒障碍的人。尽管合并症患病率很高，但 尚不知道共同的遗传因素是否有助于精神分裂症和药物使用障碍。 在这项研究中，我们使用现有的全基因组协会研究（GWAS）数据和最先进的统计数据 评估精神分裂症是否与酒精使用障碍或尼古丁共享遗传因素的方法论 依赖性。特别是，在目标1中，我们将评估有助于精神分裂症的遗传因素是否有助于 还导致饮酒障碍和尼古丁依赖性。然后，在AIM 2中，我们将评估是否 导致酒精使用障碍或尼古丁依赖性的遗传因素也有助于 精神分裂症。这个新颖的建议很重要，因为它将提高对合并症的了解 精神分裂症患有酒精使用障碍和尼古丁依赖性的遗传水平。