Microbiome Multi-Omics and Cognitive Decline in Latinos

微生物组多组学和拉丁裔认知能力下降

• 批准号: 10661289
• 负责人: Natalia Palacios
• 金额: $ 202.07万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661289
• 关键词: Acculturation; Address; Adult; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amino Acids; Amyloid; Area; Behavioral; Bifidobacterium; Bile Acids; Bioinformatics; Biological; Boston; Brain; Branched-Chain Amino Acids; Cholesterol Homeostasis; Cholic Acids; Chronic Disease; Cognition; Cognitive; Communication; Data; Dementia; Deoxycholic Acid; Diagnosis; Diet; Disparity; Ecosystem; Education; Epidemic; Epidemiology; Escherichia; Feces; Functional disorder; Funding; Future; Health; Human; Impaired cognition; Inflammation; Intervention; Investigation; Isoleucine; Latino Population; Leucine; Life Style; Light; Longitudinal Studies; Longitudinal cohort; Magnetic Resonance Imaging; Maps; Measures; Metabolic; Metabolic syndrome; Metagenomics; Microbial Taxonomy; Minority Groups; Nature; Neurocognitive; Neuroepidemiology; Neurotransmitters; Not Hispanic or Latino; Outcome; Participant; Pathway interactions; Pattern; Peptides; Plasma; Population; Prevention; Prevotella; Production; Prospective Studies; Proteins; Public Health; Puerto Rican; Research; Resolution; Risk; Role; Stress; Structure; Study of Latinos; United States National Institutes of Health; Update; Validation; Valine; Volatile Fatty Acids; Vulnerable Populations; brain health; cognitive function; cognitive testing; cohort; community based research; cytokine; dementia risk; dietary; fatty acid metabolism; gamma-Aminobutyric Acid; gut microbiome; gut microbiota; health disparity; high risk; metabolomics; microbial; microbial community; microbiome; microbiome composition; multiple omics; neurofilament; neuroinflammation; nonalzheimer dementia; pre-clinical; precision medicine; predictive modeling; prevent; prospective; response; social; social disparities; stool sample; tool development; translational impact

Project Summary/Abstract The epidemic of Alzheimer’s disease and associated cognitive decline is a critical public health challenge that will grow as the US and world populations age. US Latinos, and particularly Puerto Ricans, suffer a disproportionate burden: Puerto Ricans are at approximately double the risk of Alzheimer’s disease compared to non-Hispanic whites. Increasing evidence points to the bi-directional communication between the brain and the gut microbiome--the gut-microbiome-brain-axis--as an important factor in brain health. Despite the promising nature of this field, limited research has been done on the association between the microbiome and cognition, particularly in minority populations. Mapping the relationship between the gut microbiome and cognition in vulnerable populations such as US-based Puerto Ricans, with excess Alzheimer disease, is key to addressing current and preventing future health disparities. The proposed project will be the largest study in a minority population to date, and the first in Puerto Ricans, on the role of the gut microbiome in cognitive decline. The proposed study will leverage an established cohort--the Boston Puerto Rican Health Study (BPRHS), a longitudinal cohort with 1499 participants at baseline, three completed waves of cognitive assessments, recent MRI, and extensive covariate data. This project will develop a framework of how the human gut microbiome multi-omics contributes to cognitive trajectory and markers of AD/ADRD in Latinos. It will leverage previously collected stool samples, MRI, and 14 years of longitudinally collected data on cognition and covariates among participants of the BPRHS. Key strengths of this proposal include: 1) leverage of a large, NIH-funded prospective study of Boston area Puerto Ricans (P01AG023394, P50HL105185, R01AG055948), an underserved and understudied minority population 2) validated and updated prospective data on cognitive decline, MRI, dietary and lifestyle covariates 3) the interdisciplinary expertise of the research team, including chronic disease epidemiology, community-based research, cognition, the microbiome, MRI and predictive modeling. This study will have a strong translational impact, enabling future microbiome-targeted interventions to promote cognitive health and will contribute to the development of tools needed for a preclinical diagnosis and/or treatment of cognitive decline and Alzheimer’s disease among this vulnerable population.

项目摘要/摘要 阿尔茨海默氏病和相关认知能力下降的流行是一个关键的公共卫生挑战 随着美国和世界人口的年龄，将成长。美国拉丁美洲人，尤其是波多黎各人，遭受 不成比例的伯恩：波多黎各人的风险大约是阿尔茨海默氏病的两倍 非西班牙裔白人。增加证据指向大脑和大脑之间的双向交流 肠道微生物组 - 肠道微生物组 - 脑轴 - 是大脑健康的重要因素。尽管有 该领域的有希望的性质，对微生物组和 认知，尤其是在少数民族中。绘制肠道微生物组和 在弱势群体中的认知，例如美国的波多黎各人，患有多余的阿尔茨海默氏病，是至关重要的 解决当前并防止未来的健康差异。拟议的项目将是一项最大的研究 迄今为止的少数民族人口，也是波多黎各人的第一个人口 衰退。拟议的研究将利用已建立的队列 - 波士顿波多黎各人健康研究 （BPRHS），一个纵向队列，在基线上有1499名参与者，三个完整的认知波 评估，最近的MRI和广泛的协变量数据。 该项目将开发一个框架，说明人类肠道微生物组多派对认知的贡献 拉丁美洲人的AD/ADRD的轨迹和标记。它将利用先前收集的粪便样品，MRI和14 多年来，BPRH参与者的认知和协变量的纵向收集了数据。钥匙 该提案的优势包括：1）波士顿地区波士顿地区的大型，NIH资助的前瞻性研究的杠杆作用 RICAN（P01AG023394，P50HL105185，R01AG055948），服务不足的少数民族人口 2）验证和更新有关认知能力下降，MRI，饮食和生活方式协变量的预期数据3） 研究团队的跨学科专业知识，包括慢性疾病流行病学，基于社区 研究，认知，微生物组，MRI和预测建模。这项研究将具有很强的翻译 影响，从而实现未来的微生物组靶向干预措施以促进认知健康，并将有助于 开发临床前诊断和/或治疗认知能力下降所需的工具和阿尔茨海默氏症 这个脆弱人群中的疾病。