Motion Compensated fMRI for Pre-Surgical Planning in Epilepsy

用于癫痫手术前规划的运动补偿功能磁共振成像

• 批准号: 10659634
• 负责人: SIMON K WARFIELD
• 金额: $ 67.11万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-02 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659634
• 关键词: Affect; Benefits and Risks; Brain; Childhood; Clinical; Collection; Compensation; Computer software; Data; Elderly; Elements; Ensure; Epilepsy; Excision; Feedback; Functional Magnetic Resonance Imaging; Head; Head Movements; Image; Individual; Institution; Instruction; Intractable Epilepsy; Magnetic Resonance Imaging; Measures; Monitor; Morphologic artifacts; Motion; Noise; Operative Surgical Procedures; Outcome Assessment; Outcome Measure; Participant; Patients; Performance; Persons; Pharmacotherapy; Physiologic pulse; Play; Positioning Attribute; Recording of previous events; Risk Assessment; Role; Scanning; Series; Signal Transduction; Slice; Techniques; Technology; Time; Training; clinical practice; cohort; cost; curative treatments; design; efficacy evaluation; functional MRI scan; imaging study; improved; individual patient; neurosurgery; new technology; novel; programs; prospective; recruit; simulation; volunteer

Project Summary Epilepsy affects about 1% of people, and one-third of cases do not respond effectively to drug treatment. Patients with drug-resistant epilepsy are candidates for surgical resection of the epileptogenic zone, a potentially curative treatment. Clinical functional MRI plays a critical role in planning for neurosurgery in epilepsy. FMRI provides data to localize eloquent cortex, to assess the risks and benefits of a planned surgical resection, and to allow a resection to be tailored to the individual patient. The primary challenge to acquiring high quality functional MRI is motion of the participant. Motion reduces the temporal signal-to-noise ratio (tSNR) by misaligning the BOLD signal, motion creates spin history artifact, and motion can move parts of the brain out of the imaging field of view. These artifacts in turn lead to both false positive and false negative detections of functional activity, which compromise the fidelity of functional localization. This is usually detected and corrected to the extent possible, by discarding motion corrupted data, and using only motion-free segments. Since sufficient data must be acquired for such an analysis, fMRI acquisitions are designed to acquire redundant data to allow for loss to motion. At our institution, and others, this additional imaging time alone has been estimated to more than double the cost of fMRI imaging studies. The loss of fidelity and increased cost due to motion compromises the utility of the fMRI in planning for surgery. This is especially critical in patients who have difficulty following instructions, such as elderly, ill, or pediatric subjects. There is an unmet need for improved motion monitoring, prospective and retrospective correction for motion for fMRI. To improve the utility and decrease the cost of fMRI, we propose to develop, apply and evaluate novel technology to enable real-time self-navigated motion monitoring and improved correction for fMRI, through the following four specific aims: Aim 1: Develop and evaluate reduction of motion enabled by real-time slice-by-slice motion monitoring during fMRI; Aim 2: Develop and evaluate the reduction of motion artifact from slice by slice retrospective motion correction; Aim 3: Develop and evaluate the reduction of motion artifact from real-time slice by slice prospective motion correction (PMC); Aim 4: Assess the utility of motion monitoring, retrospective motion correction and prospective motion correction for improving functional MRI for planning for epilepsy surgery.

项目概要 大约 1% 的人患有癫痫症，其中三分之一的病例对药物治疗没有有效反应。 耐药性癫痫患者适合手术切除致痫区，这是一种 临床功能性 MRI 在神经外科手术规划中发挥着关键作用。 FMRI 提供定位语言皮质的数据，以评估计划手术的风险和益处。 切除，并允许针对个体患者进行切除是获得的主要挑战。 高质量功能性 MRI 是参与者的运动，运动会降低时间信噪比。 (tSNR) 通过错位 BOLD 信号，运动会产生旋转历史伪影，并且运动可以移动部分 这些伪影反过来会导致假阳性和假阴性。 功能活动的检测，这会损害功能定位的保真度 这通常会被检测到。 并通过丢弃运动损坏的数据并仅使用无运动的数据来尽可能地进行纠正 由于此类分析必须获取足够的数据，因此功能磁共振成像采集旨在 在我们的机构和其他机构中，获取冗余数据以允许损失额外的成像时间。 据估计，仅此一项就会使功能磁共振成像研究的成本增加一倍以上。 由于运动而增加的成本会影响功能磁共振成像在手术计划中的效用。 对于难以遵循指示的患者（例如老年人、病人或儿科受试者）至关重要。 改进运动监测、功能磁共振成像运动的前瞻性和回顾性校正的需求尚未得到满足。 提高功能磁共振成像的实用性并降低成本，我们建议开发、应用和评估新技术 通过以下方式实现实时自导航运动监测并改进功能磁共振成像校正 四个具体目标： 目标 1：开发和评估通过实时逐层运动实现的运动减少 目标 2：开发并评估逐切片运动伪影的减少 回顾性运动校正；目标 3：开发并评估实时运动伪影的减少 逐层前瞻性运动校正 (PMC)；目标 4：回顾性评估运动监测的实用性 运动矫正和前瞻性运动矫正可改善功能性 MRI，从而规划癫痫 外科手术。