Endocrinology and Metabolism Training Program

内分泌与代谢培训计划

• 批准号: 10656328
• 负责人: DAVID A. D'ALESSIO
• 金额: $ 37.18万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10656328
• 关键词: Endocrinology; Training Programs

Project Summary/Abstract The Endocrinology and Metabolism Research Training Program (T32) at Duke University Medical Center is centered on clinical and basic science investigators in the Division of Endocrinology, as well as collaborators working in other divisions and departments. The broad goal of this program is to train the next generation of biomedical scientists working in Diabetes, Metabolism and related diseases. Post-doctoral participants in this program will be either board- eligible or board-certified physicians with training in Internal Medicine or Pediatrics, or PhD scientists pursuing careers in endocrine/metabolic research. The Duke Endocrinology T32 has a long track record of training successful investigators in diabetes, metabolic bone disease, and other areas of endocrine/metabolic research. A substantial majority (80% of trainees over the past two cycles of the grant) are in academic positions at major medical centers across the US and abroad. Most are in positions with substantial research components, supported by federal, foundation, or industry grants, and the remainder have significant teaching responsibilities. The program includes training opportunities in clinical, translational, and basic research. Mentors associated with this grant have funded research programs ranging from basic science (islet biology, mitochondrial function and energetics, metabolic flux, transcriptional regulation of metabolism), to preclinical physiology using mouse genetic models, clinical physiology in humans (insulin secretion, incretin function, exercise and metabolism, bariatric surgery) to implementation science (novel approaches to diabetes care and weight management), and outcomes research (clinical trials and epidemiology). Trainees will choose primary mentors, but have access to the full breadth of the mentorship team through collaborations, didactic teaching and seminars. Training is aimed at identifying important research questions, formulating incisive hypotheses and learning to design simple but dispositive experiments; technical and analytic proficiency will also be stressed. Individuals who complete the program will be capable of independent investigation and able to translate research accomplishments into significant advances with clinical relevance.

项目摘要/摘要 杜克大学医学中心的内分泌和代谢研究培训计划（T32）是 集中于内分泌学系的临床和基础科学研究者以及合作者 在其他部门和部门工作。该计划的广泛目标是训练下一代 在糖尿病，代谢和相关疾病中工作的生物医学科学家。博士后参与者 计划将是符合条件的董事会或经过董事会认证的医生，接受内科培训或 儿科或博士学位科学家从事内分泌/代谢研究中的职业。 Duke内分泌学T32在培训糖尿病的成功调查人员的悠久记录中， 代谢骨病和内分泌/代谢研究的其他领域。绝大多数（80％ 在过去的两个赠款周期中，受训人员在主要医疗中心处于学术职位 美国和国外。大多数人都拥有大量研究组件，在联邦支持下， 基金会或行业赠款，其余的教学责任。 该计划包括临床，转化和基础研究的培训机会。导师相关 这笔赠款资助了从基础科学（胰岛生物学，线粒体）等资助的研究计划 功能和能量学，代谢通量，代谢的转录调节），临床前生理学 使用小鼠遗传模型，人类的临床生理学（胰岛素分泌，泌尿固醇功能，运动和 代谢，减肥手术）实施科学（糖尿病护理和体重的新方法 管理）和结果研究（临床试验和流行病学）。学员将选择初选 导师，但可以通过合作，教学教学来访问指导团队的全部广度 和研讨会。培训旨在确定重要的研究问题，提出尖锐的假设 并学会设计简单但处于既定的实验；技术和分析能力也将是 强调。完成该计划的个人将能够独立调查并能够 将研究成就转化为临床相关性的重大进步。