REGULATION OF NUTRIENT-STIMULATED INSULIN SECRETION BY GLP-1

GLP-1 对营养刺激的胰岛素分泌的调节

• 批准号: 7607741
• 负责人: DAVID A. D'ALESSIO
• 金额: $ 2.06万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607741
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Funding; Grant; Institution; Insulin; Intestinal Hormones; Measures; Nutrient; Persons; Regulation; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; design; glucagon-like peptide 1; insulin secretion; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to test the effect of the intestinal hormone GLP-1 to control insulin secretion in healthy persons and those with diabetes. To do this research volunteers will have insulin levels measured after meals on two occasions. The effect of GLP-1 will be determined by giving a blocker of GLP-,1 called exendin-(9-39, in one of the studies. By comparing insulin secretion with and without GLP-1 blockade, the effect of GLP-1 can be estimated from the difference in the two studies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究旨在测试肠激素GLP-1对健康患者和糖尿病患者中胰岛素分泌的影响。要做这项研究的志愿者将在两次进餐后测量胰岛素水平。 GLP-1的效果将通过给出GLP-的阻滞剂，1称为Exendin-（9-39，在其中一项研究中。通过比较有或没有GLP-1阻断的胰岛素分泌，可以从两项研究的差异中估算GLP-1的效果。