PANCREATIC ISLET CELL FUNCTION AND GLUCOSE TOLERANCE FOLLOWING TRANSPLANT

移植后的胰岛细胞功能和葡萄糖耐量

• 批准号: 7374497
• 负责人: DAVID A. D'ALESSIO
• 金额: $ 1.65万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374497
• 关键词: PANCREATIC; ISLET; CELL; FUNCTION; GLUCOSE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pancreatectomy is one approach to treating the pain syndrome associated with chronic pancreatitis. This leads to severe diabetes because of loss of pancreatic endocrine function. Isolation of the pancreatic islets at the time of surgery and return of these insulin containing cells, islet autotransplantation, is an experimental means of mitigating the diabetes associated with pancreatectomy. Previous work has established that this approach can lead to good outcomes with prevention of diabetes but it is not clear how long islet function persists after autotransplant. This study is designed to evaluate patients before and serially after islet autotransplant to determine their ability to secrete insulin and control their blood glucose. Subjects have insulin secretion measured after an infusion of arginine and during an oral glucose tolerance test. These tests are repeated at 6, 12, 24 and 36 months after surgery to determine the function of the islet grafts over time.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。胰腺切除术是治疗与慢性胰腺炎相关的疼痛综合征的一种方法。由于胰腺内分泌功能的丧失，这导致严重的糖尿病。胰岛在手术时分离胰岛和这些含胰岛素的细胞的返回（胰岛自动移植）是减轻与胰腺切除术相关的糖尿病的实验手段。先前的工作已经确定，这种方法可以通过预防糖尿病导致良好的结果，但是尚不清楚自动移植后的胰岛功能持续多长时间。这项研究旨在评估胰岛自养植物之前的患者，并在胰岛自养植物后连续串行，以确定他们分泌胰岛素和控制血糖的能力。受试者在输注精氨酸和口服葡萄糖耐受性测试后测量了胰岛素分泌。这些测试在手术后的6、12、24和36个月重复，以确定随着时间的推移胰岛移植物的功能。