Clinical Core

临床核心

• 批准号: 10656363
• 负责人: Ian Frank
• 金额: $ 36.89万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10656363
• 关键词: AIDS clinical trial group; AIDS prevention; Abbreviations; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adult; Advisory Committees; Affect; Area; Award; Basic Science; Behavioral; Behavioral Research; Biological; Biological Markers; Biological Specimen Banks; Blood; Blood Component Removal; Cannulations; Caring; Characteristics; Child; Childhood; Cities; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Collaborations; Collection; Communities; Computerized Medical Record; Consultations; Data; Databases; Development; Education; Educational Activities; Eligibility Determination; Epidemiology; Faculty; Feedback; Fostering; Foundations; Funding; Grant; HIV; HIV Infections; HIV Vaccine Trials Network; HIV disparities; HIV prevention trials network; HIV risk; HIV/AIDS; Health; Health Services Research; Health system; Helper-Inducer T-Lymphocyte; Immunologics; Immunology; Individual; Industry; Institutional Review Boards; Interdisciplinary Study; International Maternal Pediatric Adolescent AIDS Clinical Trials; Interruption; Knowledge; Laboratories; Leadership; Link; Lymph; Lymphoid; Lymphoid Tissue; Maintenance; Manuals; Mental Health; Mentors; Mentorship; Mission; Modality; Outcome; Pathogenesis; Patient Care; Patients; Pediatric Hospitals; Pennsylvania; Perinatal; Peripheral Blood Mononuclear Cell; Persons; Philadelphia; Plasma; Population; Prevention; Prevention Research; Procedures; Process; Productivity; Psychosocial Factor; Public Health; Publications; Rectum; Reporting; Research; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Risk; Risk Behaviors; Risk Factors; Science; Serum; Services; Shipping; Specimen; Specimen Handling; Strategic Planning; Technology; Thoracic Duct; Tissues; Training; Translational Research; United States National Institutes of Health; Universities; University Hospitals; Virus; acronyms; antiretroviral therapy; aspirate; clinical epidemiology; clinical material; clinical research site; data resource; design; disparity reduction; dynamical evolution; epidemiology study; first-in-human; gastrointestinal; genital secretion; health data; improved; innovation; lymph node biopsy; lymphatic duct; medical schools; member; men who have sex with men; neutralizing antibody; operation; outreach; patient oriented; pre-exposure prophylaxis; programs; protocol development; psychosocial; recruit; rectal; research study; response; service utilization; substance use; success; transgender; translational study; transmission process; trend; volunteer; working group; young men who have sex with men

Core C: Clinical ABSTRACT The Penn CFAR Clinical Core (Core C) forms the central nexus for patient-oriented interdisciplinary research conducted by CFAR investigators to advance knowledge that will improve the lives of people affected by HIV/AIDS, including adults, adolescents (behaviorally infected), and children (perinatally infected). Core C's overarching objectives are to: (a) galvanize basic, translational, clinical, epidemiologic, and behavioral research by providing investigators with a broad range of data and clinical material from HIV-infected individuals, including both biomedical and behavioral data, and stored and freshly-acquired specimens including a highly innovative new program of access to lymphoid and other tissues; (b) support for recruitment of HIV-infected or at-risk individuals into clinical studies; (c) provide advice, consultation and expertise in utilization of these services and clinical study development; and (d) provide education, training, mentorship and leadership in clinical research. Core C is led by Drs. Ian Frank (Director), and Elizabeth Lowenthal and Vincent Lo Re (Co-Directors). Over the current funding period, Core C has contributed to >150 research projects with important discoveries in HIV reservoirs, first-in-human clinical trials, and other HIV/AIDS research priority areas. The Clinical Core achieves its mission through essential services for CFAR investigators including: (1) Data and subject recruitment via an Adult/Adolescent Database comprised of >3000 patients cared for at one adolescent and 4 adult HIV practices, and a Pediatric Database with longitudinal data on 275 perinatally infected children; (2) Patient material via the CFAR Adult/Adolescent & Pediatric Specimen Repositories linked to the Databases, and by procurement of fresh material, including blood, apheresis products, genital secretions, gastrointestinal tissue, lymph node biopsies & aspirates, and lymph via cannulation of the thoracic duct; (3) Consultation on design and execution of clinical and translational studies, assistance with IRB issues, and laboratory assistance with processing, storage, and shipment of clinical specimens; (4) Educational activities & mentorship for trainees and junior faculty to advance their research and enhance success in clinical/translational AIDS research. The Clinical Core's services, leadership and expertise have evolved over the current funding cycle in response to emerging opportunities and priorities identified through proactive strategic planning, user feedback, and input from internal and external advisors. The Core fosters research aligned with NIH and Penn CFAR HIV/AIDS research priorities, including the agendas of the two CFAR Scientific Working Groups: HIV Reservoirs & Tissue Immunology and Technology to Reduce HIV Disparities. Looking ahead, several recently-introduced innovations will be featured and expanded in the coming funding cycle, including access to lymphoid tissues relevant to understanding virus persistence, immunologic control and the HIV cure research agenda; increased emphasis on adolescent populations, and access to additional data resources relevant to research on HIV disparities and increased integration with Philadelphia Department of Health activities.

核心C：临床 抽象的 Penn CFAR临床核心（Core C）形成了面向患者的跨学科的中心联系 CFAR调查人员进行的研究旨在提高知识，以改善受影响的人们的生活 由艾滋病毒/艾滋病（包括成年人，青少年（行为感染）和儿童（围产期感染））。核心C 总体目标是：（a）基本，翻译，临床，流行病学和行为 通过为研究人员提供来自HIV感染者的广泛数据和临床材料的研究， 包括生物医学和行为数据，并存储和新鲜获得的标本，包括高度 创新的新计划，以获取淋巴机和其他组织； （b）支持招募HIV感染的 或处于临床研究中的处于危险中； （c）提供有关利用的建议，咨询和专业知识 这些服务和临床研究开发； （d）提供教育，培训，指导和 临床研究领导。 Core C由Drs领导。伊恩·弗兰克（董事）和伊丽莎白·洛芬塔尔和文森特 Lo Re（联合导演）。在当前的资助期间，核心C为> 150个研究项目做出了贡献 HIV水库，人类临床试验和其他HIV/AIDS研究优先领域的重要发现。 临床核心通过为CFAR调查人员提供基本服务来实现其使命，包括：（1）数据和数据 通过成人/青少年数据库招募的受试者招募，该数据库由一个青少年的> 3000名患者组成 和4种成人艾滋病毒习惯，以及一个儿科数据库，其中有275名受周期感染儿童的纵向数据； （2）通过CFAR成人/青少年和小儿标本存储库与数据库相关的患者材料， 并通过采购新鲜材料，包括血液，寄托产物，生殖器分泌物，胃肠道 组织，淋巴结活检和抽吸物以及通过胸腔管道插管的淋巴； （3）咨询 设计和执行临床和翻译研究，IRB问题的帮助以及实验室协助 随着临床标本的加工，存储和运输； （4）教育活动和指导 学员和初级教师可以进步他们的研究并增强临床/转化艾滋病研究的成功。 临床核心的服务，领导和专业知识在当前的资金周期中发展了 通过积极的战略计划，用户反馈和意见来确定新兴的机会和优先事项 来自内部和外部顾问。核心促进研究与NIH和Penn CFAR HIV/AIDS一致的研究 研究优先级，包括两个CFAR科学工作组的议程：HIV水库和组织 免疫学和技术减少艾滋病毒差异。展望未来，最近引入了 创新将在即将到来的资金周期中进行特征和扩展，包括进入淋巴组织 与了解病毒持久性，免疫控制和HIV治疗研究议程有关；增加 强调青少年人群，并访问与艾滋病毒研究有关的其他数据资源 差异和与费城卫生活动的融合增加。