Clinical

临床

• 批准号: 7684969
• 负责人: Ian Frank
• 金额: $ 33.69万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684969
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Adipose tissue; Adolescent; Adult; Basic Science; Behavioral; Behavioral Sciences; Biology of HIV Infection; Biology of HIV Transmission; Biopsy; Blood Component Removal; Cell Volumes; Cerebrospinal Fluid; Characteristics; Child; Childhood; Clinical; Clinical Research; Collecting Cell; Collection; Consultations; Data; Databases; Development; Discipline; Ensure; Equipment and supply inventories; Faculty; Failure; Funding; Gap Junctions; Gastrointestinal tract structure; HIV; Hepatitis Viruses; Hospitals; Individual; Interdisciplinary Study; Laboratories; Link; Longitudinal Studies; Lymph; Maintenance; Manuals; Mentors; Mission; Outcome; Outcomes Research; Patient Care; Patients; Peripheral; Philosophy; Plasma Cells; Population; Preparation; Prevention; Procedures; Process; Recruitment Activity; Research; Research Ethics Committees; Research Personnel; Research Priority; Research Support; Resources; Sampling; Science; Serum; Services; Shipping; Ships; Specimen; Specimen Handling; Structure; Tissues; Training and Education; Vaccines; Venous blood sampling; Viral Load result; Virus Replication; Women' s Health; base; clinical material; clinical phenotype; design; epidemiologic data; flexibility; gastrointestinal; genital secretion; high risk behavior; improved; meetings; patient oriented; protocol development; repository; vaccine development

The Clinical Core (Core C) forms the central nexus of clinical, translational and patient sample-based interdisciplinary HIV research conducted by Penn CFAR investigators. Its central objective is to offer basic, translational, clinical, epidemiologic, and behavioral science investigators from multiple programmatic disciplines quick access to a broad range of epidemiologic data and clinical material from HIV infected individuals characterized in detail, as well as the identification of HIV infected individuals for recruitment into cross sectional or longitudinal studies. In support of this mission the Clinical Core provides CFAR investigators with: (1) an Adult/Adolescent Database comprised of nearly 3000 patients cared for at Penn-affiliated adult HIV practices at four hospitals and one adolescent (behaviorally infected) practice, and a Pediatric Database including longitudinal data on 275 perinatally infected children; (2) Adult/Adolescent and Pediatric Specimen Repositories linked to the Databases, (3) the capability to supply investigators with fresh patient material, including large volumes of cells collected by phlebotomy or apheresis, genital secretions, gastrointestinal lymph tissue and peripheral adiopose tissue biopsies, and cerebrospinal fluid; and (4) the use of laboratory support for the processing, storage, and shipment of clinical specimens. In addition, the Clinical Core (5) provides a mentoring structure for trainees and junior faculty. In the coming funding cycle we plan to expand these services to further support CFAR investigator needs. The Adult/Adolescent Database will be enlarged to include 4000 subjects. A focused recruitment of subjects for inclusion in the Specimen Repository will be conducted to expand the volume of patient material from HIV infected individuals with specific clinical phenotypes, including acute illness, effective control of virus replication in the absence of therapy, high viral loads off therapy, virologic failure, dual-tropic or mixtures of R5+X4 virus, and hepatitis coinfection. HIV uninfected individuals engaged in high risk behaviors will be recruited for a new initiative concentrating on the biology of HIV transmission. Effort will be expended to augment the portfolio of interdisciplinary research focused on women's health issues, the biology of HIV infection in the gastrointestinal tract, and science related to the development of an effective vaccine. The services provided by the Clinical Core will be evaluated annually to ensure that investigators' needs are met and utilization of the resources is maximized.

临床核心（核心C）形成了临床，转化和患者样本的中心联系 Penn CFAR研究人员进行的跨学科HIV研究。它的核心目标是提供基本 来自多个程序化的翻译，临床，流行病学和行为科学研究者 学科快速进入广泛的流行病学数据和受HIV感染的临床材料 详细描述的个人，以及对艾滋病毒感染的个体的识别，以招募 横截面或纵向研究。为了支持此任务，临床核心为CFAR提供 研究人员： （1）一个成人/青少年数据库，该数据库由近3000名在Penn隶属的成年人 在四家医院和一个青少年（行为感染）实践和一个儿科数据库中的艾滋病毒练习 包括有关275名围产期感染儿童的纵向数据； （2）成人/青少年和小儿标本 链接到数据库的存储库，（3）为调查人员提供新鲜的患者材料的能力， 包括大量通过静脉切开术或分足，生殖器分泌，胃肠道收集的细胞 淋巴组织和外周adopose组织活检和脑脊液； （4）使用实验室 支持临床标本的加工，存储和装运。另外，临床核心（5） 为学员和初级教师提供指导结构。 在即将到来的资金周期中，我们计划扩大这些服务，以进一步支持CFAR调查员 需要。成人/青少年数据库将扩大，包括4000名受试者。专注的招聘 将进行包含在样品存储库中的受试者以扩大患者材料的体积 来自患有特定临床表型的艾滋病毒感染者，包括急性疾病，有效控制 病毒复制在没有治疗的情况下，高病毒负荷降低了治疗，病毒学衰竭，双性恋或 R5+X4病毒的混合物和肝炎共感染。艾滋病毒未感染的人从事高风险行为 将招募一项新计划，重点关注HIV传播的生物学。努力将被花费 为了增加跨学科研究的投资组合，重点是妇女的健康问题，艾滋病毒的生物学 胃肠道的感染以及与有效疫苗开发有关的科学。这 临床核心提供的服务将每年评估，以确保满足调查人员的需求 并最大程度地利用了资源。