Core 3: Pathology & Biospecimens Core

核心 3：病理学

• 批准号: 10716159
• 负责人: BRENDA Y HERNANDEZ
• 金额: $ 15.2万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10716159
• 关键词: Address; Affect; Asian Americans; Asian population; Biological Specimen Banks; Blood; Blood specimen; Breast; Cancer Burden; Cancer Center; Cancer Patient; Cancer Research Project; Cells; Choline Kinase; Clinical; Cohort Studies; Collection; Colorectal; Colorectal Cancer; Communities; Community Hospitals; Community Participation; Consent; Cultural Sensitivity; Development; Diagnosis; Disparate; Endometrial Carcinoma; Endometrium; Ensure; Equity; Ethnic Population; Etiology; Excess Mortality; Feces; Filipino; Formalin; Foundations; Freezing; Future; Goals; Hawaii; Hexokinase 2; Human; Image; Individual; Infrastructure; Investigation; Japanese; Japanese American; Length; Liver; Lung; MDM2 gene; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Mammary Gland Parenchyma; Medical; Methylation; Minority Groups; Minority Health Research; Multiple Myeloma; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Not Hispanic or Latino; Oral; Oral cavity; Organoids; Oropharyngeal; Outcome; Pacific Islander; Paraffin Embedding; Pathogenesis; Pathology; Pathway interactions; Population; Primary carcinoma of the liver cells; Procedures; Program Research Project Grants; Protein Kinase; Reliability of Results; Reporting; Research; Research Personnel; Resources; SPHK1 enzyme; Samoan; Sampling; Slide; Somatomedins; Specimen; Standardization; Stomach; TP53 gene; Testing; Tissues; Translational Research; Tumor Tissue; Universities; Urine; Viral hepatitis; anticancer research; biobank; cancer health disparity; cancer risk; career; diagnosis standard; epidemiology study; ethnic difference; ethnic disparity; ethnic diversity; ethnic minority; ethnic minority population; experience; human subject; malignant breast neoplasm; malignant stomach neoplasm; melanoma; minimally invasive; minority communities; minority health disparity; mortality; multi-ethnic; nonalcoholic steatohepatitis; programs; prospective; racial difference; racial disparity; racial minority; racial minority population; repository; sample collection; telomere; translational cancer research; translational potential; tumor; tumor registry

SUMMARY /ABSTRACT Access to relevant biospecimens is critical to translational research on minority populations. The lack of research specimens from racial and ethnic minority populations in the U.S. remains a barrier to understanding racial/ethnic differences in cancer development, progression, and outcomes. In particular, the paucity of clinical biospecimens from understudied populations, including Native Hawaiians, other Pacific Islanders, and Asian Americans has limited the ability to address critical disparities in cancer risk and outcomes affecting these U.S. communities. Hawaiʻi, the most ethnically diverse state in the nation, has experienced a higher burden of common cancers-- including liver, breast, lung, colorectum, endometrium, and stomach, compared to the U.S overall. Moreover, wide racial and ethnic disparities are observed within Hawaiʻi's uniquely diverse multiethnic population including Native Hawaiians who have the highest mortality for breast, liver, lung, and other common malignancies. The value of the biospecimens collected at the University of Hawaiʻi Cancer Center (UHCC) is evident in the breadth and scope of its translational research. Despite this progress, biorepository efforts at the UHCC to date have been fragmented and limited for certain types of specimens, especially fresh frozen tumor tissue. Current UHCC biospecimen resources include a statewide repository of clinically-annotated, de-identified archival formalin-fixed paraffin-embedded (FFPE) tumor tissue and prospectively and retrospectively collected blood, urine, oral rinses, and stool from consented individuals. In contrast, the collection of fresh frozen tissue has been largely limited to small scale collections for disparate investigator-initiated studies. There is a crucial need at UHCC to standardize and centralize the collection of fresh frozen tumor and blood from cancer patients in our participating community hospitals and to integrate these collections with existing resources in order to optimize their utility for cancer research. We propose to develop a Pathology and Biospecimen Core that will integrate and augment existing and new biospecimen resources with respect to their acquisition, processing, tracking, storage, and distribution and will support Project 1 (NASH/liver cancer), Project 2 (lung cancer), Project 3 (breast cancer), Career Enhancement Program (CEP) and Developmental Research Program (DRP) projects, as well as other UHCC investigations with the goal of developing a robust infrastructure to address differences in cancer risk and outcomes in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) ethnic minority populations. Aim 1 will focus on the development of a repository of paired fresh frozen tumor tissue and blood specimens from multiethnic cancer cases diagnosed in the state of Hawaiʻi with cancers of the lung, liver, breast, colorectum, endometrium, pancreas, and stomach. Potential cases will be identified via rapid reporting from medical facilities statewide through the NCI SEER Hawaiʻi Tumor Registry. For Aim 2, we will provide biospecimens from new and existing resources in support of Projects 1, 2, and 3, CEP and DRP projects, and future cancer research projects.

摘要/摘要 获取相关生物样本对于少数群体的转化研究至关重要。 来自美国少数民族人口的研究样本仍然是理解的障碍 癌症发生、进展和结果方面的种族/民族差异，特别是临床的缺乏。 来自未充分研究人群的生物样本，包括夏威夷原住民、其他太平洋岛民和亚洲人 美国人解决影响美国人的癌症风险和结果方面的重大差异的能力有限。 夏威夷是全国种族最多元化的州，承受着更高的负担。 与美国相比，常见癌症——包括肝癌、乳腺癌、肺癌、结直肠癌、子宫内膜癌和胃癌 总体而言，夏威夷独特的多元化多民族内部存在着广泛的种族和民族差异。 包括夏威夷原住民在内的人群，其乳腺癌、肝脏、肺部和其他常见疾病的死亡率最高 夏威夷大学癌症中心 (UHCC) 收集的生物样本的价值是 尽管取得了这些进展，但生物样本库的努力仍表现在其转化研究的广度和范围上。 迄今为止，UHCC 已被分割并仅限于某些类型的标本，尤其是新鲜冷冻肿瘤 当前的 UHCC 生物样本资源包括全州范围内的临床注释、去识别化的存储库。 存档福尔马林固定石蜡包埋 (FFPE) 肿瘤组织并前瞻性和回顾性收集 相比之下，收集的是来自同意的个体的血液、尿液、口腔冲洗液和粪便。 很大程度上仅限于不同研究者发起的研究的小规模收集。 UHCC 需要标准化和集中收集癌症患者的新鲜冷冻肿瘤和血液 在我们参与的社区医院中，并将这些藏品与现有资源整合起来，以便 我们建议开发一个病理学和生物样本核心，以优化其在癌症研究中的效用。 整合和增强现有和新的生物样本资源的获取， 处理、跟踪、存储和分发，并将支持项目 1（NASH/肝癌）、项目 2（肺癌） 癌症）、项目 3（乳腺癌）、职业提升计划 (CEP) 和发展研究计划 (DRP) 项目以及其他 UHCC 调查，其目标是开发强大的基础设施 解决亚裔美国人、夏威夷原住民和太平洋岛民癌症风险和结果的差异 (AANHPI) 少数民族人口的目标 1 将重点开发配对新鲜冷冻资源库。 夏威夷州诊断出的多种族癌症病例的肿瘤组织和血液样本 肺、肝、乳腺、结直肠、子宫内膜、胰腺和胃的潜在病例将通过以下方式识别。 为了实现目标 2，我们通过 NCI SEER 夏威夷肿瘤登记处从全州医疗机构进行快速报告。 将利用新资源和现有资源提供生物样本，以支持项目 1、2 和 3、CEP 和 DRP 项目和未来的癌症研究项目。