Association Study of Orofacial Cleft Risk Variants across All of Us Cancer Diagnoses

所有癌症诊断中口面裂风险变异的关联研究

• 批准号: 10654330
• 负责人: Mary L. Marazita
• 金额: $ 11.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10654330
• 关键词: Address; Administrative Supplement; Behavior Therapy; Child; Cleft Lip; Data; Data Set; Dental; Face; Genes; Genetic; Genetic Risk; Goals; Grant; Human; Individual; Infant Mortality; Intervention; Life; Live Birth; Malignant Neoplasms; Medical; Nutritional; Operative Surgical Procedures; Palate; Public Health; Risk Factors; Speech; Structural Congenital Anomalies; Treatment Cost; Variant; cancer diagnosis; cancer risk; comorbidity; data harmonization; feeding; genetic architecture; health economics; high risk; mortality; orofacial cleft; parent grant; risk variant

ABSTRACT This new grant is a Revision/Administrative Supplement to parent grant R03-DE032062. It has long been noted that individuals with orofacial clefts (OFCs) and their unaffected relatives have a higher risk of certain cancers. The hypothesis of this revision is that the association between OFC and cancer is in part due to genetic commonalities. In this Revision, we will investigate possible associations between OFC genetic risk variants with the cancer diagnoses in All of Us.

抽象的 这项新拨款是对父拨款 R03-DE032062 的修订/行政补充。早就有人注意到 患有口面裂 (OFC) 的个人及其未受影响的亲属患某些疾病的风险较高 癌症。本次修订的假设是 OFC 与癌症之间的关联部分是由于 遗传的共性。在本次修订中，我们将调查 OFC 遗传风险之间可能存在的关联 《我们所有人》中癌症诊断的变异。