Research Experience & Training Core

研究经历

• 批准号: 10698050
• 负责人: Ying Chen
• 金额: $ 7.43万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10698050
• 关键词: Address; Area; Biological; Biological Markers; Biomedical Research; Biosensor; Chemicals; Chemistry; Communication; Communities; Community Outreach; Competence; Connecticut; Data Analyses; Data Analytics; Development; Dioxanes; Discipline; Early identification; Education; Educational process of instructing; Educational workshop; Engineering; Ensure; Environmental Engineering technology; Environmental Health; Environmental Protection; Evaluation; Exposure to; Faculty; Fostering; Genetic; Goals; Government Agencies; Health; Hepatocarcinogenesis; Industry; Information Dissemination; Infrastructure; Interdisciplinary Study; Joints; Knowledge; Malignant neoplasm of liver; Medicine; Mentors; Mentorship; Monitor; Play; Population; Postdoctoral Fellow; Privatization; Process; Program Research Project Grants; Public Health; Public Health Schools; Research; Research Activity; Research Personnel; Risk; Role; Scientist; Students; Superfund; Technology; Toxicology; Training; Training Programs; Translational Research; Universities; University resources; Update; Water Pollutants; Water Supply; academic preparation; base; community engagement; data management; design; doctoral student; drinking water; environmental chemical; environmental chemistry; experience; exposed human population; improved; liver injury; medical schools; metabolomics; next generation; novel; oxidation; potential biomarker; pre-doctoral; programs; recruit; remediation; reproductive; sensor; skills; symposium; synergism

ABSTRACT The Yale Superfund Research and Training Program (YSRTP) will foster problem-based, solution-oriented research related to the theme of water contaminant fate, exposure, remediation, and adverse health effects. To be most effective, this endeavor requires cross-trained scientists, engineers, and biomedical researchers with wide-ranging communication skills to successfully address emerging research and health questions. The proposed YSRTP unites the fields of public health, medicine, genetics, environmental chemistry, environmental engineering, and chemical fate and transport. We will leverage this disciplinary diversity, departmental and University resources, and YSRTP’s diverse research areas and cores to produce trainees with depth in their specialized field, and a breadth of knowledge and professional experiences in environmental health, chemistry, and engineering; disciplines that are important for controlling exposure to hazardous environmental chemicals. The goal of the YSRTP Research Experience Training Coordination Core (RETCC) is to expand the breadth of educational, research, and professional development opportunities to pre- and post-doctoral trainees. Four specific aims are proposed. 1. Recruit a cadre of diverse, academically prepared doctoral students and post- doctoral researchers; 2. Provide interdisciplinary training through a requirement of cross-disciplinary coursework and focused training in community outreach, results dissemination, risk communication, and research translation; 3. Design and implement a program for interdisciplinary research exchanges within and external to Yale; and 4. Encourage trainee professional development through planned interactions with community partners, government agencies, and private industry. RETCC central activities will include specific symposia and workshops to broaden trainee education and research skillsets, mentorship programs to prepare students for candidacy exams and monitor dissertation progress; a graduate research seminar and other ancillary activities to encourage interaction among trainees and build a scholastic community, and an evaluation process to continually update and improve the RETCC. Training will leverage the broader Yale University teaching, research, and mentoring infrastructure and build synergies with the YSRTP cores in administration (research translation), community engagement and data management and analytics. This training core will focus on pre- and post-doctoral trainees working in the fields of chemistry, environmental engineering, public health, and biomedical research within the YSRTP and includes an interdisciplinary (environmental engineering and biomedical research) directorship. Specific research areas include: the effects of water contaminants on reproductive toxicology, evaluation of 1,4-Dioxane (1.4-DX) exposure and early biological effects in drinking water, identification of early vs. late 1,4-DX-induced liver damage and carcinogenesis and of potential biomarkers of exposure, biosensors and chemical sensors and online contaminant monitoring, development of next-generation, modular advanced oxidation process technology.

抽象的 耶鲁大学超级基金研究与培训计划（YSRTP）将促进基于问题的，面向解决方案的 与水污染物命运，暴露，补救和不良健康影响的主题有关的研究。到 最有效，这项努力需要经过培训的科学家，工程师和生物医学研究人员 大范围的沟通技巧成功地解决了新兴的研究和健康问题。这 拟议的YSRTP单位公共卫生，医学，遗传学，环境化学，环境 工程，化学命运和运输。我们将利用这种纪律多样性，部门和 大学资源以及YSRTP的潜水员研究领域和核心，以产生深度的学员 专业领域，以及环境健康，化学方面的知识和专业经验， 和工程；对于控制暴露于危险环境化学物质的学科。 YSRTP研究经验培训协调核心（RETCC）的目标是扩大 教育，研究和专业发展的机会，以提供前和博士后学员。四个 提出了具体目标。 1。招募由潜水员，学术准备的博士生和后的干部 博士研究人员； 2。通过跨学科的要求提供跨学科培训 课程和集中培训在社区宣传，结果传播，风险交流和 研究翻译； 3.设计和实施一个用于跨学科研究交流的计划和 耶鲁大学外部； 4。通过计划的互动来鼓励学员的专业发展 社区合作伙伴，政府机构和私营企业。 RETCC中央活动将包括特定的 研讨会和讲习班，以扩大学员的教育和研究技能，精明计划以准备 候选人考试的学生并监控论文进展；研究生研究和其他 辅助活动，以鼓励学员之间的互动和建立学术界，并 评估过程不断更新和改善RETCC。培训将利用更广泛的耶鲁大学 大学教学，研究和心理基础设施，并与YSRTP核心建立协同作用 管理（研究翻译），社区参与以及数据管理和分析。 该培训核心将重点关注在化学，环境领域工作的博士后学员 YSRTP内的工程，公共卫生和生物医学研究，包括跨学科 （环境工程和生物医学研究）董事职位。特定的研究领域包括：影响 在生殖毒理学上的水污染物，评估1,4-DX（1.4-DX）和早期 饮用水中的生物学作用，鉴定早期与1,4-DX诱导的肝损伤和 癌变以及暴露，生物传感器和化学传感器以及在线的潜在生物标志物 污染物监测，下一代，模块化高级氧化过程技术的发展。