Methods for Fast and Efficient Oxygen Imaging

快速高效的氧气成像方法

• 批准号: 10698818
• 负责人: Mrignayani Kotecha
• 金额: $ 40万
• 依托单位: O2M TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10698818
• 关键词: 3-Dimensional; Acceleration; Acute; Animal Model; Attention; Clinic; Clinical; Complex; Computer software; Development; Electron Spin Resonance Spectroscopy; Environment; Evaluation; Fast Electron; Frequencies; Future; Goals; Hour; Human; Hypoxia; Image; Imaging Device; Inbred C3H Mice; Individual; Injury; Leg; Letters; Licensing; Machine Learning; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modeling; Myocardial Infarction; National Cancer Institute; Organ Transplantation; Oxygen; Pathway interactions; Performance; Perfusion; Periodicity; Phase; Physiologic pulse; Process; Radiation Dose Unit; Radiation therapy; Reporting; Resolution; Scientist; Speed; Stroke; System; Techniques; Technology; Testing; Time; Tissues; Tumor Biology; United States National Institutes of Health; Width; absorption; cancer imaging; cancer therapy; computerized data processing; deep learning; design; drug development; fibrosarcoma; image reconstruction; imager; imaging modality; imaging software; improved; in vivo; in vivo imaging; instrument; learning network; mouse model; pre-clinical; pressure; reconstruction; response; success; technology platform; therapy resistant; tool; tumor; tumor hypoxia

Abstract Intermittent or acute/cyclic hypoxia in tumors, with frequencies between a few cycles per minute to hours, is receiving increased attention because this type of hypoxia has been reported to have an influence on tumor malignancy as well as treatment resistance via increased expression of pro-survival pathways. Fast oxygen imaging methods are needed for the measurement of acute tumor hypoxia. Pulse electron paramagnetic resonance imaging (pEPRI) is a promising tool to provide three-dimensional partial oxygen pressure (pO2) maps in live tissues and tumors to assist with advanced studies of tumor biology, perfusion, drug development, and radiation treatment. Single point imaging (SPI), an acquisition technique developed at National Cancer Institute (NCI), is a subset of pEPRI methods that can be used for oxygen image acquisition. It provides high-resolution, high-fidelity images but is slow due to the need for acquiring each k-space point individually. In the current project, our goal is to improve the image acquisition speed of SPI by utilizing a combination of advanced hardware and deep learning. This will improve the imaging speed by many folds without compromising the image quality. These advances will be tested in a mouse model of fibrosarcoma tumor. This project will bring an NIH-developed technology to the commercial level. Our long-term goal is to imply the advanced hardware and software technologies of oxygen imaging to clinics to assist with oxygen-guided tumor treatments.

抽象的 肿瘤中的间歇性或急性/循环缺氧，频率在每分钟几个至小时之间， 由于据报道这种类型的缺氧对肿瘤有影响 恶性肿瘤和抗治疗性通过增加临床途径的表达。快速氧气 测量急性肿瘤缺氧需要成像方法。脉冲电子顺磁性 共振成像（PEPRI）是提供三维部分氧气（PO2）地图的有前途的工具 在活组织和肿瘤中，以帮助进行肿瘤生物学，灌注，药物开发和 辐射处理。单点成像（SPI），一种在国家癌症研究所开发的收购技术 （NCI）是可用于氧图像采集的pepri方法的子集。它提供了高分辨率， 高保真图像，但由于需要单独获取每个K空间点而慢。在电流中 项目，我们的目标是通过使用高级的组合来提高SPI的图像获取速度 硬件和深度学习。这将提高成像速度，而不会损害 图像质量。这些进步将在纤维肉瘤肿瘤的小鼠模型中进行测试。这个项目将带来一个 NIH开发的技术达到了商业层面。我们的长期目标是暗示高级硬件和 氧成像的软件技术到诊所，以帮助氧引导的肿瘤处理。