University of Utah Genetics Training Program

犹他大学遗传学培训计划

• 批准号: 10654719
• 负责人: KENT G GOLIC
• 金额: $ 58.88万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654719
• 关键词: Genetic; Training Programs; Universities; Utah

PROJECT SUMMARY/ABSTRACT The proposed Genetics Training Program (UGTP) at the University of Utah (UofU) will provide in-depth training in Genetics for a diverse group of 12 predoctoral students, arming them with scientific and professional knowledge and skills needed to conduct independent and rigorous research and become leaders within the biomedical research workforce. The U of U has a well-established, successful graduate training effort in genetics research, including a long-running Genetics T32 (45 years). The proposed new UGTP is an intensive two-year program of training in quantitative analysis, rigorous and transparent experimental practices, professional skills, the ethical practice of science, mentorship, and equity/inclusivity. These foundational objectives support the development of future multi-dimensional leaders and mentors in genetics research. The UGTP engages trainees at a formative stage of their career, in their 2nd and 3rd years of graduate school. Benefits of the program extend both before and after the intensive two-year training period. Completion of a pre-requisite first year graduate curriculum covering basic transmission genetics, ethical practices in research, critical thinking, hypothesis development, and understanding of rigor and reproducibility is required for the UGTP. Students who successfully pass a Capstone Exam administered at the end of Year 1, assessing trainee potential for independent research and rigor in scientific analysis and experimental thinking, are eligible for the UGTP. Each year about 12% of the approximately 50 TGE students are selected to become trainees. Trainees convene year-round in a suite of enriching activities. The central feature of the Training Program is a seminar course led by the PDs, limited to trainees, in which the students i) present research, critically evaluate progress, and discuss scientific best practices; undertake continued training in ii) RCR and iii) rigor, transparency, and reproducibility; participate in workshops on iv) professional development, v) mentoring; and vi) recognizing and responding to biased behaviors. Trainees present their research progress annually before the entire UofU Genetics community and select and host visiting genetics speakers throughout the year. Three advanced courses in quantitative and genetics analyses provide a breadth of training in the field of Genetics. The UGTP provides continuous mentorship in research and professional development: trainees develop IDPs with the Program Directors, adopt an extra mentor from the UGTP Steering Committee who provides guidance and communication with the UGTP, and participate in events aimed at career development and building an inclusive community. Following two years of UGTP-supported research with one of 61 UGTP faculty, trainees remain engaged through a novel initiative of near-peer mentorship, a program feature that supports the scientific and cultural development and mentoring skills of our trainees. The UGTP engages the entire UofU genetics community year-round through external speakers, Concepts in Genetics Seminars, and an Annual Retreat featuring trainee talks, plenary speakers, and poster presentations from the UofU genetics community.

项目摘要/摘要 犹他大学（UOFU）拟议的遗传学培训计划（UGTP）将提供深入的培训 在遗传学专业的12名学生的遗传学中，以科学和专业的方式武装他们 进行独立和严格研究所需的知识和技能，并成为领导者 生物医学研究人员。 U的U属于公认，成功的研究生培训工作 遗传学研究，包括长期运行的遗传学T32（45年）。拟议的新UGTP是一个密集的 定量分析，严格和透明实验实践的两年培训计划， 专业技能，科学的道德实践，指导和公平/包容性。这些基础 目标支持遗传学研究中未来多维领导者和导师的发展。 UGTP在职业生涯的成长阶段，在研究生院的第二年和三年中与学员互动。 该计划的好处延长了两年的密集培训期之前和之后。完成 第一年的第一年研究生课程涵盖基本传播遗传学，研究中的道德实践， 批判性思维，假设的发展以及对严格和可重复性的理解是 UGTP。成功通过了在第1年底进行管理的顶峰考试的学生，评估受训者 在科学分析和实验思维方面进行独立研究和严格的潜力，有资格 UGTP。每年，大约50名TGE学生中约有12％被选为学员。 学员全年在一系列丰富的活动中召集。培训计划的主要特征是 由PDS领导的研讨会课程仅限于受训者，在该课程中，学生i）进行研究，批判性评估 进步并讨论科学最佳实践；在ii）RCR和iii）严格的情况下进行持续培训， 透明度和可重复性；参加IV）专业发展的研讨会，v）指导；和 vi）认识并应对偏见行为。学员每年都会提出他们的研究进展 整个UOFU遗传学社区，全年选择和主持遗传学演讲者。三 定量和遗传学分析的先进课程为遗传学领域提供了广泛的培训。 UGTP提供了研究和专业发展的持续指导：受训者开发IDP 与计划主管一起，采用UGTP指导委员会的额外导师，该指导委员会提供指导 以及与UGTP的沟通，并参加旨在职业发展和建立的活动 包容性社区。在与61名UGTP教师之一的一名UGTP支持的研究中，受训者 通过一项近对指导的新型计划保持参与，该计划功能支持该计划 科学和文化发展和学员的指导技能。 UGTP与整个UOFU互动 遗传学社区全年通过外部演讲者，遗传学研讨会的概念和年度 由UOFU遗传学社区的务虚会，全体演讲者和海报演示的务虚会。

项目成果

Integrating Precision Medicine into the Standard of Care for Male Infertility: What Will it Take?

• DOI: 10.1016/j.eururo.2022.06.015
• 发表时间: 2022-10-01
• 期刊: EUROPEAN UROLOGY
• 影响因子: 23.4
• 作者: Kunisaki, Jason;Quinlan, Aaron;Hotaling, James
• 通讯作者: Hotaling, James

Chromosome Tug of War: Dicentric Chromosomes and the Centromere Strength Hypothesis.

• DOI: 10.3390/cells11223550
• 发表时间: 2022-11-10
• 期刊: CELLS
• 影响因子: 6
• 作者: Hill, Hunter J.;Golic, Kent G.
• 通讯作者: Golic, Kent G.

Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.

组蛋白 4 赖氨酸 5/12 乙酰化使 Pristionchus 口腔形态具有发育可塑性。

• DOI: 10.1038/s41467-023-37734-z
• 发表时间: 2023-04-13
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Werner, Michael S. S.;Loschko, Tobias;King, Thomas;Reich, Shelley;Theska, Tobias;Franz-Wachtel, Mirita;Macek, Boris;Sommer, Ralf J. J.
• 通讯作者: Sommer, Ralf J. J.

Rapid Evolution of Glycan Recognition Receptors Reveals an Axis of Host-Microbe Arms Races beyond Canonical Protein-Protein Interfaces.

• DOI: 10.1093/gbe/evad119
• 发表时间: 2023-07-03
• 期刊: GENOME BIOLOGY AND EVOLUTION
• 影响因子: 3.3
• 作者: Hilbert, Zoe A.;Haffener, Paige E.;Young, Hannah J.;Schwiesow, Mara J. W.;Leffler, Ellen M.;Elde, Nels C.
• 通讯作者: Elde, Nels C.

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma.

FoxA1/2 依赖性表观基因组重编程驱动肺腺癌谱系转换。

• DOI: 10.1101/2023.10.30.564775
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Gillis,Katherine;Orellana,WalterA;Wilson,Emily;Parnell,TimothyJ;Fort,Gabriela;Dadzie,HeadtloveEssel;Zhang,Xiaoyang;Snyder,EricL
• 通讯作者: Snyder,EricL