Differentiating clinical characteristics between two subtypes of antiphosphatidylethanolamine

区分抗磷脂酰乙醇胺两种亚型的临床特征

基本信息

批准号：
10654055
负责人：
Rosalind Ramsey-Goldman
金额：
$ 20万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10654055
关键词：
Antibodies Antigens Antiphospholipid Antibodies Antiphospholipid Syndrome Autoantibodies Binding Cardiolipins Cellular Membrane Characteristics Clinical Clinical Data Clinical Research Complement Activation Data Diagnosis Discipline of obstetrics Endocytosis Funding Mechanisms Future Goals High Prevalence Individual Investigation Knowledge Laboratories Learning Literature Lupus Coagulation Inhibitor Molecular Odds Ratio Pathogenesis Pathogenicity Pathway interactions Patient Care Patients Phosphatidylethanolamine Plasma Population Pregnancy Pregnancy Complications Preparation Proteins Research Retrospective Studies Sampling Secure Series Standardization Structure Symptoms Testing Thrombosis Venous Thrombosis beta 2-glycoprotein I clinical practice clinically significant cofactor complement 4b-binding protein complement system experimental study obstetrical complication preference prospective thrombotic thrombotic complications trafficking

项目摘要

ABSTRACT Antiphosphatidylethanolamine (aPE) autoantibodies are associated with clinical symptoms of antiphospholipid syndrome (APS). However, the clinical significance of aPE remains to be fully established. In an effort to define aPE, we discovered that aPE actually consists of two distinctive subtypes. This notion is based on our findings that there are two types of aPE antibodies – cofactor-independent (aPEi) and cofactor-dependent (aPEd), which have different antigens and pathogenic mechanisms. In the current effort, we will investigate the clinical characteristics of aPE subtypes in a retrospective study by testing the hypothesis that aPEi and aPEd antibodies have different associations with the clinical and laboratory criteria for APS. The new knowledge will help define and differentiate the two subtypes of aPE, with potentially important implications on diagnosis and patient care.

抽象的抗磷脂酰乙醇胺 (aPE) 自身抗体与抗磷脂的临床症状相关然而，aPE 的临床意义仍有待完全确定。 aPE，我们发现 aPE 实际上由两种不同的亚型组成，这个概念是基于我们的发现。 aPE 抗体有两种类型：辅因子独立型 (aPEi) 和辅因子依赖型 (aPEd)，具有不同的抗原和致病机制，目前我们将研究其临床。通过检验 aPEi 和 aPEd 抗体的假设，回顾性研究中 aPE 亚型的特征与 APS 的临床和实验室标准有不同的关联。新知识将有助于定义。并区分 aPE 的两种亚型，这对诊断和患者护理具有潜在的重要影响。