EPIDEMIOLOGY OF OSTEOPOROSIS IN WOMEN WITH LUPUS - MAMDC PROJECT

狼疮女性骨质疏松症的流行病学 - MAMDC 项目

• 批准号: 7604235
• 负责人: Rosalind Ramsey-Goldman
• 金额: $ 0.32万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604235
• 关键词: EPIDEMIOLOGY; OSTEOPOROSIS; WOMEN; LUPUS; MAMDC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims to be addressed in this study are: 1) To estimate the differences in bone mineral density (BMD) at the hip and lumbar spine between 240 women with lupus and a comparable control group of 200 women matched by age, race, and menopause status; 2) To determine the association of lupus risk factors with low BMD in women with lupus, after controlling for traditional risk factors for low BMD; 3) To follow the subjects entered in the cross-sectional study over a two year period in order to estimate the difference in the rate of bone loss at the hip and lumbar spine between women with lupus and a comparable control group matched by age, race, and menopause status; and 4) To determine the association of lupus risk factors with increased rates of bone loss in women with lupus, after controlling for traditional risk factors for low BMD. The hypotheses to be examined in this study are: 1a) women with lupus have lower BMD at the hip and spine than matched controls; 1b) the negative effect of lupus on bone mineral density at the hip and spine is greater in Caucasian than in African-American women; 2a) traditional risk factors for low BMD (multiparty and menopause status, irregular menstrual cycles or premature menopause, avoidance of oral contraceptives and/or hormone replacement therapy, lower physical activity level, and decreased vitamin D levels) are associated with lower BMD at the hip or lumbar spine in women with lupus; 2b) lupus risk factors (greater disease activity, greater disease severity, higher corticosteroid burden, use of anticonvulsant drugs, and the presence of renal disease) are associated with lower BMD at the hip or lumbar spine in women with lupus, after controlling for traditional risk factors for low BMD; 3a) women with lupus have accelerated bone loss at the hip and spine during two additional years of lupus disease compared with matched controls followed for two years; 3b) the effect of lupus on the rate of bone loss at the hip and spine is greater in Caucasian than in African-American women; 4a) traditional osteoporosis risk factors (mentioned in 2a above) are associated with accelerated bone loss in women with lupus; and 4b) lupus risk factors (mentioned in 2b above) are associated with accelerated bone loss at the hip or lumbar spine in women with lupus, after controlling for traditional risk factors for low BMD.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究要解决的具体目标是： 1) 评估 240 名狼疮女性与由 200 名年龄、种族和性别相匹配的女性组成的对照组之间的髋部和腰椎骨矿物质密度 (BMD) 差异。更年期状态； 2) 在控制低 BMD 的传统危险因素后，确定狼疮危险因素与狼疮女性低 BMD 的关系； 3) 对参与横断面研究的受试者进行为期两年的跟踪，以估计狼疮女性与年龄、种族相匹配的对照组之间髋部和腰椎骨质流失率的差异和更年期状态； 4) 在控制低 BMD 的传统危险因素后，确定狼疮危险因素与狼疮女性骨质流失率增加的关系。 本研究要检验的假设是： 1a) 患有狼疮的女性的臀部和脊柱的 BMD 低于匹配的对照组； 1b) 狼疮对白种人髋部和脊柱骨矿物质密度的负面影响比非裔美国女性更大； 2a) 低 BMD 的传统危险因素（多方和绝经状态、月经周期不规则或过早绝经、避免口服避孕药和/或激素替代疗法、较低的体力活动水平和维生素 D 水平降低）与较低的 BMD 相关患有狼疮的女性的髋部或腰椎； 2b) 狼疮危险因素（更大的疾病活动性、更严重的疾病严重程度、更高的皮质类固醇负担、使用抗惊厥药物以及存在肾脏疾病）与狼疮女性髋部或​​腰椎的 BMD 较低相关，在控制传统方法后骨密度低的危险因素； 3a) 与两年后的匹配对照相比，患有狼疮的女性在狼疮病的另外两年内，髋部和脊柱的骨质流失加速； 3b) 狼疮对白种人髋部和脊柱骨质流失率的影响大于非裔美国女性； 4a) 传统的骨质疏松症危险因素（上文 2a 中提到的）与狼疮女性骨质流失加速相关； 4b) 在控制低 BMD 的传统危险因素后，狼疮危险因素（上文 2b 中提到的）与狼疮女性髋部或​​腰椎骨质流失加速相关。