EPIDEMIOLOGY OF OSTEOPOROSIS IN WOMEN WITH LUPUS - MAMDC PROJECT

狼疮女性骨质疏松症的流行病学 - MAMDC 项目

• 批准号: 7604235
• 负责人: Rosalind Ramsey-Goldman
• 金额: $ 0.32万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604235
• 关键词: EPIDEMIOLOGY; OSTEOPOROSIS; WOMEN; LUPUS; MAMDC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims to be addressed in this study are: 1) To estimate the differences in bone mineral density (BMD) at the hip and lumbar spine between 240 women with lupus and a comparable control group of 200 women matched by age, race, and menopause status; 2) To determine the association of lupus risk factors with low BMD in women with lupus, after controlling for traditional risk factors for low BMD; 3) To follow the subjects entered in the cross-sectional study over a two year period in order to estimate the difference in the rate of bone loss at the hip and lumbar spine between women with lupus and a comparable control group matched by age, race, and menopause status; and 4) To determine the association of lupus risk factors with increased rates of bone loss in women with lupus, after controlling for traditional risk factors for low BMD. The hypotheses to be examined in this study are: 1a) women with lupus have lower BMD at the hip and spine than matched controls; 1b) the negative effect of lupus on bone mineral density at the hip and spine is greater in Caucasian than in African-American women; 2a) traditional risk factors for low BMD (multiparty and menopause status, irregular menstrual cycles or premature menopause, avoidance of oral contraceptives and/or hormone replacement therapy, lower physical activity level, and decreased vitamin D levels) are associated with lower BMD at the hip or lumbar spine in women with lupus; 2b) lupus risk factors (greater disease activity, greater disease severity, higher corticosteroid burden, use of anticonvulsant drugs, and the presence of renal disease) are associated with lower BMD at the hip or lumbar spine in women with lupus, after controlling for traditional risk factors for low BMD; 3a) women with lupus have accelerated bone loss at the hip and spine during two additional years of lupus disease compared with matched controls followed for two years; 3b) the effect of lupus on the rate of bone loss at the hip and spine is greater in Caucasian than in African-American women; 4a) traditional osteoporosis risk factors (mentioned in 2a above) are associated with accelerated bone loss in women with lupus; and 4b) lupus risk factors (mentioned in 2b above) are associated with accelerated bone loss at the hip or lumbar spine in women with lupus, after controlling for traditional risk factors for low BMD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在本研究中要解决的具体目的是：1）估计240名患有狼疮的妇女与髋关节和腰椎处的骨矿物质密度（BMD）的差异，以及与年龄，种族和更年期状态相匹配的200名女性的可比对照组； 2）在控制低BMD的传统危险因素之后，确定狼疮女性中狼疮风险因素与BMD低的关联； 3）要遵循两年内横断面研究中进入的受试者，以估计狼疮女性与狼疮女性与符合年龄，种族和更年期状态相匹配的可比对照组之间髋关节和腰椎骨质流失率的差异； 4）在控制低BMD的传统危险因素之后，确定狼疮风险因素与狼疮女性骨质流失率的关联。 在这项研究中要检查的假设是：1A）狼疮女性在臀部和脊柱上的BMD低于匹配的对照； 1b）白种人在高加索人中对髋关节和脊柱骨矿物质密度的负面影响要比非裔美国妇女更大。 2A）低BMD的传统危险因素（多律和更年期状态，不规则的月经周期或更年期，避免口服避孕药和/或激素替代疗法，较低的体育活动水平以及维生素D的降低）与Lupus女性的髋或脑脊柱较低的BMD相关。 2B）狼疮危险因素（疾病活动更大，疾病严重程度更大，皮质类固醇负担更高，使用抗惊厥药和肾脏疾病的存在）与狼疮女性在臀部或腰椎处于较低的BMD相关，在控制传统的BMD传统风险因素后， 3A）狼疮女性在另外两年的狼疮疾病中加速了臀部和脊柱的骨质流失，而随后进行了两年的匹配对照。 3b）白种人在高加索人中对髋关节和脊柱骨质流失率的影响要比非裔美国妇女大； 4A）传统的骨质疏松症风险因素（上述2a中提到）与狼疮女性的加速骨质流失有关；在控制低BMD的传统危险因素之后，狼疮的危险因素（上述2B中提到）与臀部或腰椎的加速骨质流失有关。