PREDICTORS OF PREGNANCY OUTCOMES IN SLE AND APS

SLE 和 APS 妊娠结局的预测因素

• 批准号: 7604310
• 负责人: Rosalind Ramsey-Goldman
• 金额: $ 0.09万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604310
• 关键词: PREDICTORS; PREGNANCY; OUTCOMES; SLE; APS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study examined pregnancy outcomes over the course of the subject's pregnancy through three months postpartum. Physical examinations and urine and blood tests will be conducted during the subject's pregnancy and during the postpartum time period, as well as interviews with the subject regarding her pregnancy. A complete medical history will also be obtained. This information will be used to gain a better understanding of the relationship between pregnancy success and low complement deficiencies in women with Systemic Lupus Erythematosus (SLE) or Antiphospholipid syndrome (APS). The study will seek to measure the following outcomes/events: 1) unexplained fetal death occurring 12 weeks after gestation, 2) neonatal death prior to hospital discharge and due to complications of prematurity, 3) indicated preterm delivery prior to 36 weeks' gestation because of gestational hypertension, pre-eclampsia or placental insufficiency, and 4) intrauterine growth restriction (IUGR) which is defined as neonatal birth weight less than the 10th percentile for gestational age. Further, the study will also seek to identify whether classical, alternative, and terminal complement pathway activation will be detected in the circulation and placenta of patients with aPL antibodies, and associated with poor pregnancy outcomes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究检查了受试者从怀孕到产后三个月的妊娠结局。 将在受试者怀孕期间和产后期间进行体格检查以及尿液和血液检查，并就其怀孕情况对受试者进行访谈。 还将获得完整的病史。 该信息将用于更好地了解患有系统性红斑狼疮 (SLE) 或抗磷脂综合征 (APS) 的女性妊娠成功与低补体缺乏之间的关系。 该研究将寻求衡量以下结局/事件：1）妊娠 12 周后发生不明原因的胎儿死亡，2）出院前因早产并发症而导致的新生儿死亡，3）妊娠 36 周之前表明早产，因为妊娠高血压、先兆子痫或胎盘功能不全，以及 4) 宫内生长受限 (IUGR)，定义为新生儿出生体重低于正常体重胎龄的第 10 个百分位。 此外，该研究还将寻求确定是否会在具有 aPL 抗体的患者的循环和胎盘中检测到经典、替代和终末补体途径激活，以及是否与不良妊娠结局相关。