PREDICTORS OF PREGNANCY OUTCOMES IN SLE AND APS

SLE 和 APS 妊娠结局的预测因素

• 批准号: 7604310
• 负责人: Rosalind Ramsey-Goldman
• 金额: $ 0.09万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604310
• 关键词: PREDICTORS; PREGNANCY; OUTCOMES; SLE; APS; PREDICTORS; PREGNANCY; OUTCOMES; SLE; APS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study examined pregnancy outcomes over the course of the subject's pregnancy through three months postpartum. Physical examinations and urine and blood tests will be conducted during the subject's pregnancy and during the postpartum time period, as well as interviews with the subject regarding her pregnancy. A complete medical history will also be obtained. This information will be used to gain a better understanding of the relationship between pregnancy success and low complement deficiencies in women with Systemic Lupus Erythematosus (SLE) or Antiphospholipid syndrome (APS). The study will seek to measure the following outcomes/events: 1) unexplained fetal death occurring 12 weeks after gestation, 2) neonatal death prior to hospital discharge and due to complications of prematurity, 3) indicated preterm delivery prior to 36 weeks' gestation because of gestational hypertension, pre-eclampsia or placental insufficiency, and 4) intrauterine growth restriction (IUGR) which is defined as neonatal birth weight less than the 10th percentile for gestational age. Further, the study will also seek to identify whether classical, alternative, and terminal complement pathway activation will be detected in the circulation and placenta of patients with aPL antibodies, and associated with poor pregnancy outcomes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究检查了在产后三个月的怀孕期间，妊娠结局。 身体检查，尿液和血液检查将在受试者的怀孕期间和产后期间进行，以及对受试者怀孕的访谈。 还将获得完整的病史。 这些信息将用于更好地了解妊娠成功与较低补体缺乏之间的关系，患有狼疮性红斑狼疮（SLE）或抗磷脂综合征（APS）的女性。 该研究将寻求衡量以下结果/事件：1）妊娠后12周发生无法解释的胎儿死亡，2）在出院前的新生儿死亡以及由于早产的并发症，3）指示在妊娠36周之前的早产，因为妊娠高血压是由于妊娠高度高度高度超高，预智能或胎儿的生长，以及与胎儿的固定依赖（4）内在（4）内部依赖（4）Incontictional（4）Incontional in Intratife and AtaTimentAntional in Intaintictimation（4）小于胎龄的第10个百分点。 此外，该研究还将寻求确定在具有APL抗体的患者的循环和胎盘中是否会检测到经典，替代性和末端补体途径激活，并且与妊娠结局差有关。