Shape Analysis Toolbox: From medical images to quantitative insights of anatomy

形状分析工具箱：从医学图像到解剖学的定量见解

• 批准号: 10646162
• 负责人: Beatriz Paniagua
• 金额: $ 47.55万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-19 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646162
• 关键词: 3-Dimensional; Accounting; Algorithms; Anatomy; Architecture; Automobile Driving; Biological; Biological Markers; Biomedical Research; Brain; Classification; Clinical Research; Communities; Complex; Computer software; Consultations; Data; Development; Disease; Documentation; Educational workshop; Effectiveness; Ensure; Event; Fostering; Funding; Geometry; Goals; Image; Image Analysis; Infrastructure; Longitudinal Studies; Measures; Medical; Medical Imaging; Methodology; Methods; Modeling; Modernization; Nature; Online Systems; Pediatric cardiology; Phase; Population; Process; Publications; Research; Research Design; Research Personnel; Shapes; Software Tools; Statistical Methods; Structure; Surveys; Techniques; Testing; Time; Training; Ultrasonography; Variant; Visualization; base; biomedical imaging; biomedical scientist; clinical application; complex data; computer science; deep learning; design; digital; efficacy evaluation; fetal; geometric structure; imaging study; improved; innovation; insight; large scale data; longitudinal analysis; new technology; novel; open source; outreach; shape analysis; statistics; success; tool; usability; web site

PROJECT SUMMARY Three-dimensional shape lies at the core of understanding the physical objects that surround us. The Shape AnaLysis Toolbox (SALT) was created to be a dissemination vehicle for advanced shape modeling and analysis methodology as an open-source, comprehensive and freely distributed software. Over the past four years, we have been successful in increasing the ease of use and effectiveness of state-of-the-art shape analysis methodology for biomedical researchers in need of such techniques. We now propose necessary and novel enhancements to our methods and our dissemination model in order to continue maximizing the success of SALT. We will also modify the architecture of SALT to better integrate biomedical imaging research workflows by improving the efficiency and scripting capabilities so SlicerSALT can be deployed in batch mode for large-scale sequential computations. We will also shift our focus from shape modeling into state-of-the-art statistical shape analysis methodologies, necessary to serve clinical applications and to increase the interpretability of shape biomarkers. We will continue to disseminate novel example applications that best demonstrate how to use our tools to perform impactful research and will provide fully digital documentation for user support. The ultimate goal of SlicerSALT is to maximize the potential benefits of the geometric information contained in medical data and to expand its use beyond simple visualization to support clinical research.

项目摘要 三维形状是了解我们周围物理物体的核心。形状 分析工具箱（盐）被创建为用于高级形状建模和的传播工具 分析方法作为开源，全面且自由分布的软件。在过去的四个 多年来，我们已经成功地提高了最先进形状的易用性和有效性 需要此类技术的生物医学研究人员的分析方法。 现在，我们提出了对我们的方法和传播模型的必要和新颖的增强，以便 继续最大化盐的成功。我们还将修改盐的结构以更好地整合 生物医学成像研究工作流程通过提高效率和脚本功能，因此切片 可以在批处理模式下进行大规模顺序计算。我们还将将重点从 形状建模为最先进的统计形状分析方法，为临床服务所必需 应用并提高形状生物标志物的解释性。我们将继续传播小说 最能说明如何使用我们的工具进行有影响力的研究的示例应用程序并将提供 完全数字文档以用于用户支持。 切片的最终目标是最大化所包含的几何信息的潜在优势 医疗数据并扩大其用途，超出简单可视化以支持临床研究。

项目成果

An open-source solution for shape modeling and analysis of objects of challenging topologies.

用于形状建模和分析具有挑战性拓扑的对象的开源解决方案。

• DOI: 10.1117/12.2579716
• 发表时间: 2021
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Vicory,Jared;Allemang,David;Zukic,Dzenan;Prothero,Jack;McCormick,Matthew;Paniagua,Beatriz
• 通讯作者: Paniagua,Beatriz

Skeletons, Object Shape, Statistics

• DOI: 10.3389/fcomp.2022.842637
• 发表时间: 2022-10
• 期刊: Frontiers in computer science
• 影响因子: 2.6
• 作者: S. Pizer;J. S. Marron;J. Damon;Jared Vicory;A. Krishna;Zhiyuan Liu;Mohsen Taheri

Brain structure in sagittal craniosynostosis.

矢状位颅缝早闭的脑结构。

• DOI: 10.1117/12.2254442
• 发表时间: 2017
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Paniagua,Beatriz;Kim,Sunghyung;Moustapha,Mahmoud;Styner,Martin;Cody-Hazlett,Heather;Gimple-Smith,Rachel;Rumple,Ashley;Piven,Joseph;Gilmore,John;Skolnick,Gary;Patel,Kamlesh
• 通讯作者: Patel,Kamlesh

Conformal initialization for shape analysis applications in SlicerSALT.

SlicerSALT 中形状分析应用的保形初始化。

• DOI: 10.1117/12.2503894
• 发表时间: 2019
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Fang,Zhengyang;Mostapha,Mahmoud;Prieto,Juan;Styner,Martin
• 通讯作者: Styner,Martin

ESTIMATING SHAPE CORRESPONDENCE FOR POPULATIONS OF OBJECTS WITH COMPLEX TOPOLOGY.

估计具有复杂拓扑的物体群的形状对应性。

• DOI: 10.1109/isbi.2018.8363742
• 发表时间: 2018
• 期刊: Proceedings. IEEE International Symposium on Biomedical Imaging
• 作者: Fishbaugh,James;Pascal,Laura;Fischer,Luke;Nguyen,Tung;Boen,Celso;Goncalves,Joao;Gerig,Guido;Paniagua,Beatriz
• 通讯作者: Paniagua,Beatriz