Shape Analysis Toolbox for Medical Image Computing Projects

用于医学图像计算项目的形状分析工具箱

基本信息

批准号：
9354487
负责人：
Beatriz Paniagua
金额：
$ 52.35万
依托单位：
KITWARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-19 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9354487
关键词：
Affect Anatomy Atrophic Biological Biomedical Research Brain Charge Clinical Collaborations Communities Computer software Computers Data Development Documentation Educational workshop Ensure Epilepsy Event Four-dimensional Frequencies Functional disorder Future Glutamates Hippocampus (Brain)Image Imaging technology Industry Standard Informatics Intuition Link Longitudinal Studies Maintenance Measurement Measures Medical Medical Imaging Medical Research Methodology Methods Modeling Morphology Operative Surgical Procedures Outcome Pathologic Patients Performance Quantitative Evaluations Questionnaires Regression Analysis Research Research Personnel Resources Sampling Science Scientist Seizures Shapes Software Tools Statistical sensitivity Structure Testing Time Tissues Training Universities Update Validation Work bioimaging biomedical scientist craniofacial imaging study improved innovation interest maxillofacial meetings neuroimaging novel open source outreach public health relevance shape analysis skeletal statistics success tool usability visual information

项目摘要

DESCRIPTION (provided by applicant): The work proposed in this application aims to continue the maintenance, expansion, validation and dissemination of the SPHARM-PDM (SPherical HARMonics Point Distributed Models) shape analysis toolbox. Shape analysis is of high interest to the biomedical sciences due to its potential to precisely locate morphological changes in pathological structures. SPHARM-PDM is a successful and popular open-source software tool that has been used by the biomedical research community to analyze the morphology of anatomical structures. Most of the existing shape analysis packages lack of integration with publicly available segmentation software tools and are very complicated to use in general. These are the main reasons why shape analysis studies have been performed mainly by larger labs or through close collaboration with computer scientists that specialize in shape analysis. With this proposal we look into maintaining the core functionalities that made of SPHARM-PDM a successful toolbox, as well as into providing a close integration with important segmentation packages and dramatically extending the toolbox into a general shape analysis toolbox (Shape AnaLysis Toolbox, SALT). New methodologies will provide support for objects of non-spherical topology, skeletal models, four-dimensional (4D) models, and study-specific optimal model correspondence. All new methodologies of SALT will be then tested using three application case scenarios to evaluate the efficacy of the proposed new functionalities and to provide an illustration of usability and best practices for the user community. In parallel with th major development and maintenance efforts, we will continue providing excellent documentation, community resources, and user support.

描述（由申请人提供）：本申请中提出的工作旨在继续维护、扩展、验证和传播 SPHARM-PDM（SPherical HARMonics 点分布式模型）形状分析工具箱。形状分析对生物医学科学非常重要。由于其具有精确定位病理结构形态变化的潜力，SPHARM-PDM 是一种成功且流行的开源软件工具，已被生物医学研究界用来分析病理结构。大多数现有的形状分析软件包缺乏与公开可用的分割软件工具的集成，并且通常使用起来非常复杂，这些是形状分析研究主要由大型实验室或通过密切合作进行的主要原因。与专门从事形状分析的计算机科学家合作，我们着眼于维护使 SPHARM-PDM 成为成功工具箱的核心功能，并提供与重要分割包的紧密集成，并将工具箱显着扩展为通用形状。分析工具箱（形状AnaLysis Toolbox，SALT）。新方法将为非球形拓扑、骨架模型、四维 (4D) 模型和特定于研究的最佳模型对应关系提供支持，然后将使用三个应用程序来测试 SALT 的所有新方法。案例场景来评估所提议的新功能的功效，并为用户社区提供可用性和最佳实践的说明。在进行主要开发和维护工作的同时，我们将继续提供优秀的文档、社区资源和用户支持。