Shape Analysis Toolbox: From medical images to quantitative insights of anatomy

形状分析工具箱：从医学图像到解剖学的定量见解

基本信息

批准号：
10363506
负责人：
Beatriz Paniagua
金额：
$ 47.39万
依托单位：
KITWARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-19 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10363506
关键词：
3-Dimensional Accounting Address Algorithms Anatomy Architecture Automobile Driving Biological Biological Markers Biomedical Research Brain Classification Clinical Research Communities Complex Computer software Consultations Data Development Disease Documentation Educational workshop Ensure Event Fostering Funding Geometry Goals Image Analysis Infrastructure Longitudinal Studies Measures Medical Medical Imaging Methodology Methods Modeling Modernization Nature Online Systems Pediatric cardiology Phase Population Process Publications Research Research Design Research Personnel Shapes Software Tools Statistical Methods Structure Surveys Techniques Testing Three-Dimensional Image Time Training Ultrasonography Use Effectiveness Variant Visualization base biomedical imaging biomedical scientist clinical application complex data computer science deep learning design digital efficacy evaluation fetal geometric structure imaging study improved innovation insight large scale data longitudinal analysis new technology novel open source outreach shape analysis statistics success tool usability web site

项目摘要

PROJECT SUMMARY Three-dimensional shape lies at the core of understanding the physical objects that surround us. The Shape AnaLysis Toolbox (SALT) was created to be a dissemination vehicle for advanced shape modeling and analysis methodology as an open-source, comprehensive and freely distributed software. Over the past four years, we have been successful in increasing the ease of use and effectiveness of state-of-the-art shape analysis methodology for biomedical researchers in need of such techniques. We now propose necessary and novel enhancements to our methods and our dissemination model in order to continue maximizing the success of SALT. We will also modify the architecture of SALT to better integrate biomedical imaging research workflows by improving the efficiency and scripting capabilities so SlicerSALT can be deployed in batch mode for large-scale sequential computations. We will also shift our focus from shape modeling into state-of-the-art statistical shape analysis methodologies, necessary to serve clinical applications and to increase the interpretability of shape biomarkers. We will continue to disseminate novel example applications that best demonstrate how to use our tools to perform impactful research and will provide fully digital documentation for user support. The ultimate goal of SlicerSALT is to maximize the potential benefits of the geometric information contained in medical data and to expand its use beyond simple visualization to support clinical research.

项目概要三维形状是理解我们周围的物理对象的核心。形状 AnaLysis Toolbox (SALT) 的创建目的是作为高级形状建模和分析的传播工具分析方法作为一种开源、全面且免费分发的软件。过去四年多年来，我们成功地提高了最先进形状的易用性和有效性为需要此类技术的生物医学研究人员提供分析方法。我们现在对我们的方法和传播模型提出必要和新颖的改进，以便继续最大限度地提高 SALT 的成功率。我们还将修改SALT的架构以更好地集成通过提高生物医学成像研究工作流程的效率和脚本功能，SlicerSALT 可以以批处理模式部署以进行大规模顺序计算。我们也将把注意力从将形状建模转化为最先进的统计形状分析方法，这是服务临床所必需的应用并增加形状生物标志物的可解释性。我们将继续传播小说示例应用程序最好地演示了如何使用我们的工具进行有影响力的研究，并将提供用于用户支持的全数字文档。 SlicerSALT 的最终目标是最大限度地发挥其中包含的几何信息的潜在优势医疗数据，并将其用途扩展到简单的可视化之外，以支持临床研究。