KUH-TN Training Core

KUH-TN 训练核心

• 批准号: 10652603
• 负责人: Jeffrey L. Garvin
• 金额: $ 34.6万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652603
• 关键词: Area; Astronomy; Basic Science; Benign; Bibliography; Bioinformatics; Biometry; Career Choice; Clinical; Clinical Sciences; Committee Members; Communities; Computer software; Data; Development; Development Plans; Drug Targeting; Economics; Ecosystem; Engineering; Ethics; Evaluation; Feedback; Functional disorder; Funding; Goals; Hematology; Individual; Institution; Instruction; Kidney; Laboratories; Laboratory Research; Leadership; Logic; Malignant Neoplasms; Mentors; Methodology; Methods; Mission; Modeling; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; National Research Service Awards; Nature; Nephrology; Performance; Pharmaceutical Preparations; Policies; Postdoctoral Fellow; Price; Process; Production; Professional Organizations; Professional Role; Program Evaluation; Publications; Publishing; Recommendation; Registries; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Research Training; Role; San Francisco; Science; Scientist; Series; Son; Standardization; Structure; Surveys; TNFSF15 gene; Teacher Professional Development; Training; Underrepresented Populations; United States National Institutes of Health; Urology; Writing; anticancer research; career; career development; design; drug development; expectation; experience; faculty mentor; improved; innovation; interest; meetings; open data; pre-clinical; pre-clinical research; pre-doctoral; programs; recruit; responsible research conduct; skills; social cognitive theory; tool; wasting

Contact PD/PI: Sedor, John NRSA-Training-001 (104) The TL1 Research Training Core (TL1 Core) of the Cleveland Kidney, Urology and Hematology Training Network (KUH-TN) will provide a mentored research experience to predoctoral and postdoctoral trainees that will prepare them for a research career as independently funded investigators, with a focus on the core mission areas of the NIDDK: nephrology, benign urology and benign hematology (KUH). The cornerstone of the training is an intensive mentored research experience with an accomplished basic or clinical science mentor(s) in one of the KUH focus areas. This training experience is enriched with additional Core and Elective training components organized through the Professional Development Core and implemented within the TL1 core. The additional Core Training components are designed to ensure that each trainee receives in-depth instruction in the pathophysiology of the trainee's primary KUH focus area (i.e. nephrology, benign urology or benign hematology) as well as an introduction to the fundamental tools and skills broadly used in interdisciplinary and team science (i.e. scientific writing, biostatistics, responsible conduct of research, leadership and laboratory management) and an immersive clinical experience for trainees, who will not have this exposure through other training mechanisms.. Trainees will also be introduced to innovative scientific methodologies and research strategies through the KUH-TN biweekly seminar series organized by the Professional Development Core. The Elective Training components provide a variety of supplemental training experiences, customized for each trainee, as determined by the trainee and their mentor(s). Upon entering the program each trainee is assigned a Mentoring Committee that will have formal meetings with the trainee every six months. The Mentoring Committee includes a primary mentor, a professional development mentor and an additional committee member with related scientific expertise. The role of the primary research mentor is to provide material support and guidance toward the successful completion of all aspects of the mentored research project through weekly and ad hoc meetings. The role of the Professional Development Mentor will be to meet with trainees quarterly to assess progress toward career development and professional goals. The role of the additional committee member to provide additional expertise and an objective assessment of the trainee's research and professional development progress at the bi-annual committee meetings. Structured evaluation of Trainee's progress through the program is monitored by a Program Evaluation Committee using and Individual Development Plan that captures the goals and expectations of each trainees at the beginning of the year of training. The Program evaluation Committee will also provide feedback to Training faculty mentoring trainees and tools to improve their mentoring style. Finally The TL1 Core includes a Diversity and Recruitment Committee, whose role is to improve our engagement, recruitment and retention in research and related careers of all our trainees, especially individuals from underrepresented groups. Project Summary/Abstract Page 276 Contact PD/PI: Sedor, John NRSA-Training-001 (104) Bibliography and References Cited 1. Spruance, VM, Rankin, TL: Reimagining Institutional Research Training: Coordinating a Highly Interactive Community of Young Investigators Prepared to Excel. Clin J Am Soc Nephrol, 15: 1361-1363, 2020. 2. Lancaster, AK, Thessen, AE, Virapongse, A: A new paradigm for the scientific enterprise: nurturing the ecosystem. F1000Research, 7: 803, 2018. 3. Blank, R, Daniels, RJ, Gilliland, G, Gutmann, A, Hawgood, S, Hrabowski, FA, Pollack, ME, Price, V, Reif, LR, Schlissel, MS: A new data effort to inform career choices in biomedicine. Science, 358: 1388-1389, 2017. 4. Frechtling, JA: Logic Modeling Methods in Program Evaluation, San Francisco, CA, John WIley & Sons, 2007. 5. Lent, RW, Brown, SD, Hackett, GA: Toward a Unifying Social Cognitive Theory of Career and Academic Interest, Choice, and Performance. J Vocat Behav, 45: 79-122, 1994. 6. Chalmers, I, Glasziou, P: Avoidable waste in the production and reporting of research evidence. Lancet, 374: 86-89, 2009. 7. Prinz, F, Schlange, T, Asadullah, K: Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov, 10: 712, 2011. 8. Begley, CG, Ellis, LM: Drug development: Raise standards for preclinical cancer research. Nature, 483: 531- 533, 2012. 9. Baker, M: 1,500 scientists lift the lid on reproducibility. Nature, 533: 452-454, 2016. 10. Boulbes, DR, Costello, T, Baggerly, K, Fan, F, Wang, R, Bhattacharya, R, Ye, X, Ellis, LM: A Survey on Data Reproducibility and the Effect of Publication Process on the Ethical Reporting of Laboratory Research. Clin Cancer Res, 24: 3447-3455, 2018. 11. Freedman, LP, Cockburn, IM, Simcoe, TS: The Economics of Reproducibility in Preclinical Research. PLoS Biol, 13: e1002165, 2015. 12. Sandve, GK, Nekrutenko, A, Taylor, J, Hovig, E: Ten simple rules for reproducible computational research. PLoS Comput Biol, 9: e1003285, 2013. 13. Belmann, P, Droge, J, Bremges, A, McHardy, AC, Sczyrba, A, Barton, MD: Bioboxes: standardised containers for interchangeable bioinformatics software. GigaScience, 4: 47, 2015. 14. Moreews, F, Sallou, O, Menager, H, Le Bras, Y, Monjeaud, C, Blanchet, C, Collin, O: BioShaDock: a community driven bioinformatics shared Docker-based tools registry. F1000Research, 4: 1443, 2015. 15. Kurtzer, GM, Sochat, V, Bauer, MW: Singularity: Scientific containers for mobility of compute. PloS One, 12: e0177459, 2017. 16. Gruening, B, Sallou, O, Moreno, P, da Veiga Leprevost, F, Menager, H, Sondergaard, D, Rost, H, Sachsenberg, T, O'Connor, B, Madeira, F, Dominguez Del Angel, V, Crusoe, MR, Varma, S, Blankenberg, D, Jimenez, RC, BioContainers, C, Perez-Riverol, Y: Recommendations for the packaging and containerizing of bioinformatics software. F1000Research, 7, 2018. 17. Wofford, MF, Boscoe, BM, Borgman, CL, Pasquetto, IV, Golshan, MS: Jupyter Notebooks as Discovery Mechanisms for Open Science: Citation Practices in the Astronomy Community. Computing in Science & Engineering, 22: 5-15, 2020. 18. Collins, FS, Tabak, LA: Policy: NIH plans to enhance reproducibility. Nature, 505: 612-613, 2014. References Cited Page 277

联系 PD/PI：Sedor, John NRSA-Training-001 (104) 克利夫兰肾脏、泌尿科和血液学培训网络的 TL1 研究培训核心（TL1 核心） （KUH-TN）将为博士前和博士后学员提供指导性研究经验，帮助他们做好准备 他们作为独立资助的调查员从事研究职业，重点关注该中心的核心任务领域 NIDDK：肾病学、良性泌尿学和良性血液学（KUH）。培训的基石是 与一位杰出的基础或临床科学导师一起进行深入指导的研究经验，其中之一 KUH 重点领域。额外的核心和选修培训内容丰富了这种培训体验 通过专业发展核心组织并在 TL1 核心内实施。额外的 核心培训组件旨在确保每位学员都能接受深入的指导 受训者主要 KUH 重点领域的病理生理学（即肾病学、良性泌尿学或良性血液学） 以及跨学科和团队科学中广泛使用的基本工具和技能的介绍 （即科学写作、生物统计学、负责任的研究行为、领导力和实验室管理）以及 为学员提供身临其境的临床体验，他们不会通过其他培训接触到这种体验 机制...还将向学员介绍创新的科学方法和研究策略 通过专业发展核心组织的 KUH-TN 双周研讨会系列。选修课 培训组件提供了为每位学员定制的各种补充培训体验，例如 由受训者及其导师确定。进入该计划后，每个学员都会被分配一个指导 委员会每六个月与学员举行一次正式会议。指导委员会包括 一名主要导师、一名专业发展导师和一名具有相关科学知识的额外委员会成员 专业知识。主要研究导师的作用是为研究提供物质支持和指导 通过每周和特别会议成功完成指导研究项目的各个方面。这 专业发展导师的作用是每季度与学员会面，评估其进展情况 职业发展和职业目标。额外委员会成员的作用是提供额外的 专业知识以及对受训者的研究和专业发展进展的客观评估 每两年一次的委员会会议。对受训者在该计划中的进展进行结构化评估由 项目评估委员会使用个人发展计划来捕获目标和 每位学员在培训年初的期望。项目评估委员会将 还向指导受训者的培训教师提供反馈和工具，以改进他们的指导风格。最后 TL1 核心包括多元化和招聘委员会，其作用是提高我们的参与度， 招募和保留我们所有受训者的研究和相关职业，特别是来自 代表性不足的群体。 项目总结/摘要第 276 页 联系 PD/PI：Sedor, John NRSA-Training-001 (104) 参考书目和参考文献 1. Spruance, VM, Rankin, TL：重新构想机构研究培训：协调高度互动的培训 准备出类拔萃的年轻研究人员社区。临床肾病杂志，15：1361-1363，2020。 2. Lancaster, AK、Thessen, AE、Virapongse, A：科学事业的新范式：培育 生态系统。 F1000 研究，7：803，2018。 3. 布兰克，R，丹尼尔斯，RJ，吉利兰，G，古特曼，A，霍古德，S，赫拉博夫斯基，FA，波拉克，ME，普莱斯，V，赖夫，LR， Schlissel，MS：一项为生物医学职业选择提供信息的新数据工作。科学，358：1388-1389，2017。 4. Frechtling, JA：程序评估中的逻辑建模方法，加利福尼亚州旧金山，John WIley & Sons，2007 年。 5. Lent, RW、Brown, SD、Hackett, GA：走向职业和学术统一的社会认知理论 兴趣、选择和表现。 J Vocat Behav，45：79-122，1994。 6. Chalmers, I, Glasziou, P：研究证据的产生和报告中可避免的浪费。柳叶刀，374： 86-89，2009。 7. Prinz, F, Schlange, T, Asadullah, K：不管你信不信：我们在多大程度上可以依赖已发布的潜力数据 药物靶点？ Nat Rev Drug Discov，10：712，2011。 8. Begley, CG、Ellis, LM：药物开发：提高临床前癌症研究的标准。自然，483：531- 533，2012。 9. Baker, M：1,500 名科学家揭开了可重复性的神秘面纱。自然，533：452-454，2016。 10. Boulbes, DR, Costello, T, Baggerly, K, Fan, F, Wang, R, Bhattacharya, R, Ye, X, Ellis, LM：数据调查 重复性和出版过程对实验室研究道德报告的影响。 临床癌症研究，24：3447-3455，2018。 11. Freedman, LP、Cockburn, IM、Simcoe, TS：临床前研究中的再现性经济学。公共科学图书馆 生物，13：e1002165，2015。 12. Sandve, GK, Nekrutenko, A, Taylor, J, Hovig, E：可重复计算研究的十个简单规则。 《公共科学图书馆计算生物学》，9：e1003285，2013。 13. Belmann, P, Droge, J, Bremges, A, McHardy, AC, Sczyrba, A, Barton, MD：Bioboxes：标准化 可互换生物信息学软件的容器。千兆科学，4：47，2015。 14. Moreews, F, Sallou, O, Menager, H, Le Bras, Y, Monjeaud, C, Blanchet, C, Collin, O：BioShaDock：a 社区驱动的生物信息学共享基于 Docker 的工具注册表。 F1000 研究，4：1443，2015。 15. Kurtzer, GM、Sochat, V、Bauer, MW：奇点：计算移动性的科学容器。公共科学图书馆一号，12： e0177459，2017。 16. Gruening, B, Sallou, O, Moreno, P, da Veiga Leprevost, F, Menager, H, Sondergaard, D, Rost, H, 萨克森伯格，T，奥康纳，B，马德拉，F，多明格斯·德尔·安赫尔，V，克鲁索，MR，瓦尔马，S， Blankenberg, D, Jimenez, RC, BioContainers, C, Perez-Riverol, Y：包装建议 以及生物信息学软件的容器化。 F1000 研究，2018 年 7 月。 17. Wofford, MF、Boscoe, BM、Borgman, CL、Pasquetto, IV、Golshan, MS：Jupyter Notebooks 作为发现 开放科学机制：天文学界的引用实践。科学计算 与工程，22：5-15，2020。 18. Collins, FS，塔巴克，路易斯安那州：政策：NIH 计划提高可重复性。自然，505：612-613，2014。 引用的参考文献 第 277 页

项目成果

Photonic Lithotripsy: Near-Infrared Laser Activated Nanomaterials for Kidney Stone Comminution.

• DOI: 10.1021/acs.nanolett.3c01166
• 发表时间: 2023-06
• 期刊: Nano Letters
• 影响因子: 10.8
• 作者: Ian Houlihan;Benjamin Kang;Smita De;Vijay B. Krishna

Gene network profiling in muscle-invasive bladder cancer: A systematic review and meta-analysis.

• DOI: 10.1016/j.urolonc.2021.11.003
• 发表时间: 2022-05
• 期刊: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
• 影响因子: 2.7
• 作者: Isali, Ilaha;McClellan, Phillip;Calaway, Adam;Prunty, Megan;Abbosh, Phillip;Mishra, Kirtishri;Ponsky, Lee;Markt, Sarah;Psutka, Sarah P.;Bukavina, Laura
• 通讯作者: Bukavina, Laura

Transcriptome analysis suggests a central role for complement and C5aR1 in neutrophil activation in APS.

转录组分析表明补体和 C5aR1 在 APS 中性粒细胞激活中发挥核心作用。

• DOI: 10.1016/j.thromres.2023.08.014
• 发表时间: 2023
• 期刊: Thrombosis research
• 影响因子: 7.5
• 作者: Alarabi,Ahmed;Hubben,Anne;Barnard,John;Knight,JasonS;McCrae,KeithR
• 通讯作者: McCrae,KeithR

On demand plerixafor is safe and effective for hematopoietic progenitor cell mobilization in patients with light chain amyloidosis at risk for mobilization failure with G-CSF alone.

• DOI: 10.1038/s41409-023-01938-0
• 发表时间: 2023-05
• 期刊: BONE MARROW TRANSPLANTATION
• 影响因子: 4.8
• 作者: Hubben, Anne;Dima, Danai;Atieh, Tahani;Chaulagain, Chakra;Faiman, Beth;Ferraro, Christina;Mazzoni, Sandra;Williams, Louis;Samaras, Christy;Valent, Jason;Sauter, Craig;Anwer, Faiz;Khouri, Jack
• 通讯作者: Khouri, Jack

A preliminary evaluation of in vivo response to a filament-wound macroporous collagen midurethral sling in an ovine model.

• DOI: 10.1002/jbm.b.35120
• 发表时间: 2022-12
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
• 影响因子: 3.4
• 作者: Khalifa, Ahmad O.;Isali, Ilaha;Celik, Hakan;Mastran, Michael;McClellan, Phillip;Gillespie, Callan;Shankar, Subba;MacLennan, Gregory T.;Anderson, James M.;Schumacher, Fredrick R.;Akkus, Ozan;Hijaz, Adonis K.
• 通讯作者: Hijaz, Adonis K.