KUH-TN Training Core

KUH-TN 训练核心

• 批准号: 10457142
• 负责人: Jeffrey L. Garvin
• 金额: $ 37.44万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10457142
• 关键词: Area; Astronomy; Basic Science; Benign; Bibliography; Bioinformatics; Biometry; Career Choice; Clinical; Clinical Sciences; Committee Members; Communities; Computer software; Custom; Data; Development; Development Plans; Docking; Drug Targeting; Economics; Ecosystem; Engineering; Ensure; Ethics; Evaluation; Feedback; Functional disorder; Funding; Goals; Hematology; Immersion; Individual; Instruction; Kidney; Laboratories; Laboratory Research; Leadership; Logic; Malignant Neoplasms; Mentors; Methodology; Methods; Mission; Modeling; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; National Research Service Awards; Nature; Nephrology; Performance; Pharmaceutical Preparations; Policies; Price; Process; Production; Professional Role; Program Evaluation; Publications; Publishing; Recommendation; Registries; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Research Training; Role; San Francisco; Science; Scientist; Series; Son; Standardization; Structure; Surveys; TNFSF15 gene; Teacher Professional Development; Training; Underrepresented Populations; United States National Institutes of Health; Urology; Writing; anticancer research; base; career; career development; design; drug development; expectation; experience; faculty mentor; improved; innovation; interest; meetings; open data; pre-clinical; pre-clinical research; pre-doctoral; programs; recruit; responsible research conduct; skills; social cognitive theory; tool; wasting

Contact PD/PI: Sedor, John NRSA-Training-001 (104) The TL1 Research Training Core (TL1 Core) of the Cleveland Kidney, Urology and Hematology Training Network (KUH-TN) will provide a mentored research experience to predoctoral and postdoctoral trainees that will prepare them for a research career as independently funded investigators, with a focus on the core mission areas of the NIDDK: nephrology, benign urology and benign hematology (KUH). The cornerstone of the training is an intensive mentored research experience with an accomplished basic or clinical science mentor(s) in one of the KUH focus areas. This training experience is enriched with additional Core and Elective training components organized through the Professional Development Core and implemented within the TL1 core. The additional Core Training components are designed to ensure that each trainee receives in-depth instruction in the pathophysiology of the trainee's primary KUH focus area (i.e. nephrology, benign urology or benign hematology) as well as an introduction to the fundamental tools and skills broadly used in interdisciplinary and team science (i.e. scientific writing, biostatistics, responsible conduct of research, leadership and laboratory management) and an immersive clinical experience for trainees, who will not have this exposure through other training mechanisms.. Trainees will also be introduced to innovative scientific methodologies and research strategies through the KUH-TN biweekly seminar series organized by the Professional Development Core. The Elective Training components provide a variety of supplemental training experiences, customized for each trainee, as determined by the trainee and their mentor(s). Upon entering the program each trainee is assigned a Mentoring Committee that will have formal meetings with the trainee every six months. The Mentoring Committee includes a primary mentor, a professional development mentor and an additional committee member with related scientific expertise. The role of the primary research mentor is to provide material support and guidance toward the successful completion of all aspects of the mentored research project through weekly and ad hoc meetings. The role of the Professional Development Mentor will be to meet with trainees quarterly to assess progress toward career development and professional goals. The role of the additional committee member to provide additional expertise and an objective assessment of the trainee's research and professional development progress at the bi-annual committee meetings. Structured evaluation of Trainee's progress through the program is monitored by a Program Evaluation Committee using and Individual Development Plan that captures the goals and expectations of each trainees at the beginning of the year of training. The Program evaluation Committee will also provide feedback to Training faculty mentoring trainees and tools to improve their mentoring style. Finally The TL1 Core includes a Diversity and Recruitment Committee, whose role is to improve our engagement, recruitment and retention in research and related careers of all our trainees, especially individuals from underrepresented groups. Project Summary/Abstract Page 276 Contact PD/PI: Sedor, John NRSA-Training-001 (104) Bibliography and References Cited 1. Spruance, VM, Rankin, TL: Reimagining Institutional Research Training: Coordinating a Highly Interactive Community of Young Investigators Prepared to Excel. Clin J Am Soc Nephrol, 15: 1361-1363, 2020. 2. Lancaster, AK, Thessen, AE, Virapongse, A: A new paradigm for the scientific enterprise: nurturing the ecosystem. F1000Research, 7: 803, 2018. 3. Blank, R, Daniels, RJ, Gilliland, G, Gutmann, A, Hawgood, S, Hrabowski, FA, Pollack, ME, Price, V, Reif, LR, Schlissel, MS: A new data effort to inform career choices in biomedicine. Science, 358: 1388-1389, 2017. 4. Frechtling, JA: Logic Modeling Methods in Program Evaluation, San Francisco, CA, John WIley & Sons, 2007. 5. Lent, RW, Brown, SD, Hackett, GA: Toward a Unifying Social Cognitive Theory of Career and Academic Interest, Choice, and Performance. J Vocat Behav, 45: 79-122, 1994. 6. Chalmers, I, Glasziou, P: Avoidable waste in the production and reporting of research evidence. Lancet, 374: 86-89, 2009. 7. Prinz, F, Schlange, T, Asadullah, K: Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov, 10: 712, 2011. 8. Begley, CG, Ellis, LM: Drug development: Raise standards for preclinical cancer research. Nature, 483: 531- 533, 2012. 9. Baker, M: 1,500 scientists lift the lid on reproducibility. Nature, 533: 452-454, 2016. 10. Boulbes, DR, Costello, T, Baggerly, K, Fan, F, Wang, R, Bhattacharya, R, Ye, X, Ellis, LM: A Survey on Data Reproducibility and the Effect of Publication Process on the Ethical Reporting of Laboratory Research. Clin Cancer Res, 24: 3447-3455, 2018. 11. Freedman, LP, Cockburn, IM, Simcoe, TS: The Economics of Reproducibility in Preclinical Research. PLoS Biol, 13: e1002165, 2015. 12. Sandve, GK, Nekrutenko, A, Taylor, J, Hovig, E: Ten simple rules for reproducible computational research. PLoS Comput Biol, 9: e1003285, 2013. 13. Belmann, P, Droge, J, Bremges, A, McHardy, AC, Sczyrba, A, Barton, MD: Bioboxes: standardised containers for interchangeable bioinformatics software. GigaScience, 4: 47, 2015. 14. Moreews, F, Sallou, O, Menager, H, Le Bras, Y, Monjeaud, C, Blanchet, C, Collin, O: BioShaDock: a community driven bioinformatics shared Docker-based tools registry. F1000Research, 4: 1443, 2015. 15. Kurtzer, GM, Sochat, V, Bauer, MW: Singularity: Scientific containers for mobility of compute. PloS One, 12: e0177459, 2017. 16. Gruening, B, Sallou, O, Moreno, P, da Veiga Leprevost, F, Menager, H, Sondergaard, D, Rost, H, Sachsenberg, T, O'Connor, B, Madeira, F, Dominguez Del Angel, V, Crusoe, MR, Varma, S, Blankenberg, D, Jimenez, RC, BioContainers, C, Perez-Riverol, Y: Recommendations for the packaging and containerizing of bioinformatics software. F1000Research, 7, 2018. 17. Wofford, MF, Boscoe, BM, Borgman, CL, Pasquetto, IV, Golshan, MS: Jupyter Notebooks as Discovery Mechanisms for Open Science: Citation Practices in the Astronomy Community. Computing in Science & Engineering, 22: 5-15, 2020. 18. Collins, FS, Tabak, LA: Policy: NIH plans to enhance reproducibility. Nature, 505: 612-613, 2014. References Cited Page 277

与PD/PI联系：John NRSA-Training-001（104）的Setor： 克利夫兰肾脏，泌尿外科和血液学训练网络的TL1研究培训核心（TL1核心） （kuh-tn）将为托管前和博士后学员提供指导的研究经验，以准备 他们从事独立资助的研究人员的研究职业，重点是 NIDDK：肾脏学，良性泌尿科和良性血液学（KUH）。培训的基石是 在其中一位的一位基础或临床科学指导的基础或临床科学指导者中，有着密集的指导研究经验 Kuh焦点区域。这种培训经验丰富了其他核心和选择性培训组件 通过专业发展核心组织，并在TL1核心内实施。附加 核心培训组件旨在确保每个学员在 学员主要KUH焦点区域的病理生理（即肾脏学，良性泌尿科或良性血液学） 以及跨学科和团队科学广泛使用的基本工具和技能的介绍 （即科学写作，生物统计学，负责任的研究，领导和实验室管理）和 对学员的身临其境的临床经验，他们将不会通过其他培训进行这种接触 机制..学员还将被引入创新的科学方法论和研究策略 通过专业发展核心组织的KUH-TN双周研讨会系列。选修课 培训组件提供各种为每个学员定制的补充培训经验， 由实习生及其导师决定。输入计划后，每个学员被分配了指导 委员会将每六个月与学员举行正式会议。指导委员会包括 主要导师，专业发展导师和其他相关科学的委员会成员 专业知识。主要研究导师的作用是提供物质支持和指导 通过每周和临时会议成功完成指导研究项目的各个方面。这 专业发展导师的角色将是与学员每季度见面，以评估 职业发展和职业目标。额外委员会成员提供额外的角色 专业知识以及对学员的研究和专业发展进步的客观评估 两年一次的委员会会议。对学员通过该计划的进度的结构化评估由 计划评估委员会使用和个人发展计划，该计划符合目标和 在培训年初，每个学员的期望。计划评估委员会将 还为培训教师指导学员和工具提供反馈，以改善他们的指导风格。最后 TL1核心包括一个多样性和招聘委员会，其作用是改善我们的参与， 我们所有学员的研究及相关职业的招聘和保留，尤其是来自 代表性不足的群体。 项目摘要/摘要页面276 与PD/PI联系：John NRSA-Training-001（104）的Setor： 参考书目和参考文献 1。Spruance，VM，Rankin，TL：重新想象机构研究培训：协调高度互动 年轻调查人员的社区准备表现出色。 Clin J Am Soc Nephrol，15：1361-1363，2020。 2。兰开斯特，AK，泰森，AE，Virapongse，A：科学企业的新范式：培养 生态系统。 F1000 Research，7：803，2018。 3。Blank，R，Daniels，RJ，Gilliland，G，Gutmann，A，Hawgood，S，Hrabowski，FA，FA，Pollack，ME，Price，Price，V，Reif，Reif，LR，LR， Schlissel，MS：一项新的数据努力，以告知生物医学的职业选择。科学，358：1388-1389，2017。 4。JA Frechtling：计划评估中的逻辑建模方法，加利福尼亚州旧金山，John Wiley＆Sons，2007年。 5。借，RW，Brown，SD，Hackett，GA：迈向统一的职业和学术认知理论 兴趣，选择和表现。 J Vocat Chand，45：79-122，1994。 6. Chalmers，I，Glasziou，P：研究证据的生产和报告中可避免的废物。柳叶刀，374： 86-89，2009。 7。Prinz，F，Schlange，T，Asadullah，K：信不信由您：我们可以依靠有关潜在的已发表数据 药物目标？ Nat Rev Drug Discov，10：712，2011。 8。Begley，CG，Ellis，LM：药物开发：提高临床前癌症研究标准。大自然，483：531- 533，2012。 9。Baker，M：1,500名科学家在可重复性方面抬高了盖子。自然，533：452-454，2016。 10。Boulbes，Dr，Dr，Costello，T，Baggerly，K，Fan，F，Wang，R，Bhattacharya，R，Ye，Ye，X，Ellis，LM：一项有关数据调查 可重复性和出版过程对实验室研究道德报告的影响。 Clin Cancer Res，24：3447-3455，2018。 11。Freedman，LP，Cockburn，IM，Simcoe，TS：临床前研究中可重复性的经济学。 PLOS Biol，13：E1002165，2015。 12。Sandve，GK，Nekrutenko，A，Taylor，J，Hovig，E：可再现计算研究的十个简单规则。 PLOS Comput Biol，9：E1003285，2013。 13。Belmann，P，Droge，J，Bremges，A，MCHARDY，AC，SCZYRBA，A，BARTON，MD：BIBOBOXES：标准化 可互换生物信息学软件的容器。 Gigascience，4：47，2015。 14。Moreews，F，Sallou，O，Menager，H，Le Bras，Y，Monjeaud，C，Blanchet，C，Collin，o：bioshadock：a a 社区驱动的生物信息学共享基于Docker的工具注册表。 F1000 Research，4：1443，2015。 15。Kurtzer，GM，Sochat，V，Bauer，MW：奇异性：计算机活动性的科学容器。 Plos One，12： E0177459，2017。 16. Gruening，B，Sallou，O，Moreno，P，Da Veiga Leprevost，F，Menager，H，Sondergaard，D，D，Rost，H，H，H， Sachsenberg，T，O'Connor，B，Madeira，F，Dominguez del Angel，V，Crusoe，MR，Varma，S， Blankenberg，D，Jimenez，RC，Biocontainers，C，Perez-Riverol，Y：包装的建议 和生物信息学软件的容器。 F1000 Research，7，2018。 17. Wofford，MF，Boscoe，BM，Borgman，CL，Pasquetto，IV，Golshan，MS：Jupyter Notebooks作为Discovery 开放科学机制：天文学界的引文实践。科学计算 ＆Engineering，22：5-15，2020。 18。Collins，FS，Tabak，LA：政策：NIH计划增强可重复性。自然，505：612-613，2014。 引用的参考资料277