Fine-scale eye-movement differences in psychosis and their contribution to abnormal vision

精神病中的精细眼动差异及其对视力异常的影响

基本信息

批准号：
10645812
负责人：
Brian Patrick Keane
金额：
$ 23.1万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10645812
关键词：
Adult Calibration Cerebellar vermis structure Characteristics Complex Custom Data Collection Differential Diagnosis Disparate Dorsal Dyskinetic syndrome Exhibits Eye Eye Movements Facial Expression Recognition Frequencies Functional disorder Future Goals Head Helmet Image Impairment Intervention Investigation Lateral Letters Light Literature Measurement Methods Motion Patients Perception Persons Phenotype Population Positioning Attribute Prefrontal Cortex Procedures Process Psychoses Psychotic Disorders PubMed Reading Reporting Research Resolution Retina Saccades Sample Size Schizophrenia Speed Stimulus Structure System Vision Visual Visual Acuity Visual impairment Writing attentional bias biobehavior caudate nucleus clinical predictors digital frontal eye fields gaze improved interest neural novel oculomotor oculomotor behavior prevent reading ability reading difficulties retinal imaging sample fixation statistics tool visual tracking

Adult Calibration Cerebellar vermis structure Characteristics Complex Custom Data Collection Differential Diagnosis Disparate Dorsal Dyskinetic syndrome Exhibits Eye Eye Movements Facial Expression Recognition Frequencies Functional disorder Future Goals Head Helmet Image Impairment Intervention Investigation Lateral Letters Light Literature Measurement Methods Motion Patients Perception Persons Phenotype Population Positioning Attribute Prefrontal Cortex Procedures Process Psychoses Psychotic Disorders PubMed Reading Reporting Research Resolution Retina Saccades Sample Size Schizophrenia Speed Stimulus Structure System Vision Visual Visual Acuity Visual impairment Writing attentional bias biobehavior caudate nucleus clinical predictors digital frontal eye fields gaze improved interest neural novel oculomotor oculomotor behavior prevent reading ability reading difficulties retinal imaging sample fixation statistics tool visual tracking

展开

项目摘要

Project summary/abstract Eye movement abnormalities in schizophrenia (SZ) have been documented for over 100 years, yet it remains unknown whether fine-scale eye movements differ in this population. This is unfortunate because the neural structures underlying oculomotor control are well-documented, implying that group differences could shed light on the underlying illness pathophysiology. Moreover, establishing fine-scale eye movement differences could in principle provide a distinguishing biobehavioral marker, which in turn could be used for differential diagnosis or clinical prediction. Additionally, fine-scale eye movements contribute to everyday activities, such as recognizing facial expressions at a distance, reading, and discriminating fine spatial stimuli. Therefore, it is conceivable that abnormal micro- eye movements could be associated with—and even causally related to—impairments of these visual functions in psychosis. Thus, a major goal of the research described in this proposal is to establish that fine-scale eye movements do indeed differ among those with psychosis (Aim 1). These differences will be assessed in people with a psychotic disorder and in well-matched healthy adults during steady fixation and in the presence of complex foveal stimuli. In contrast to possibly all prior psychosis studies, we will use a high- precision digital Dual Purkinje Image Eye-Tracker (1 arcmin resolution) with a head-stabilizing helmet to minimize small head motions, and frequent re-calibrations throughout data collection. Additionally, a custom-made system for gaze contingent display control, will enable the implementation of a state-of-the-art calibration procedure, which effectively reduces the gaze localization error to less than 5 arcmin. Since visual acuity and reading are often impaired among psychosis patients and may even portend a future psychotic disorder, we will attempt to generate group differences with tasks that probe these same processes. Moreover, to establish a reference baseline for fine oculomotor behavior and to consider hitherto unnoticed problems in fixational stability, we will assess small eye movement differences during steady fixation without an active task. Aside from assessing whether micro- eye movement differences characterize psychosis, we will also assess their relationship to visual perceptual deficits (Aim 2). In particular, we will probe for correlations between microsaccade characteristics and the magnitude of visual acuity and reading deficits. We will also consider whether trials with a higher rate of microsaccades are related to impaired reading or impaired visual acuity compared to trials without such eye movements, and whether image stabilization on the retina (which removes the benefits of microsaccades) worsens acuity more for controls than for patients. Findings will inform our understanding of how eye movement differences in psychosis are related to perception at the micro-scale, which in turn can suggest novel treatments or interventions for improving poor visual acuity and reading.

项目摘要/摘要精神分裂症（SZ）的眼睛运动异常已记录了100多年，但仍然存在尚不清楚该人群中的细眼运动是否有所不同。这很不幸，因为神经眼动控制的基础结构有据可查，这意味着群体差异可能会散发出光线关于潜在的疾病病理生理学。此外，建立精细的眼睛运动差异可能原理提供了一个区别的生物行为标记物，反过临床预测。此外，精细的眼睛运动有助于每天的活动，例如识别面部表情在远处，阅读和区分细小的空间刺激。因此，可以想象异常的微眼运动可能与这些动作有关，甚至不幸的是与这些运动有关精神病中的视觉功能。这是本提案中描述的研究的主要目标是确定精神病患者之间的精细眼球运动确实确实有所不同（AIM 1）。这些差异将是在稳定固定期间和在患有精神病患者和匹配健康的成年人中评估复杂的凹刺激的存在。与所有先前的精神病研究相反，我们将使用高精密数字双purkinje图像轨迹（1个Arcmin分辨率），带有头盔，以最大程度地减少小型头部动作，并经常在数据收集过程中重新校准。此外，定制系统对于凝视偶然的显示控制，将实现最先进的校准过程，这有效地将凝视定位误差降低到小于5个arcmin。由于视力和阅读是在精神病患者中经常受到损害与探测这些相同过程的任务生成组差异。此外，建立参考基线的精细眼球行为，并考虑固定稳定性中隐藏的未注意到的问题，我们将在稳定固定过程中评估小眼运动差异，而无需进行主动任务。除了评估微眼运动差异是否是精神病的特征，我们还将评估它们与视觉的关系感知定义（目标2）。特别是，我们将探测微扫描特征之间的相关性以及视力和阅读缺陷的大小。我们还将考虑是否率更高与没有这种眼睛的试验相比运动，以及在视网膜上的图像稳定（这消除了微扫视的好处）对照组的敏锐度比患者更恶化。调查结果将使我们对眼睛运动的理解有关精神病的差异与微尺度的感知有关，这反过来又暗示了新的治疗方法或改善视力差和阅读差的干预措施。