Research Program: Breast & Ovary Cancers

研究项目：乳房

基本信息

批准号：
10636835
负责人：
Cyrus M Ghajar
金额：
$ 7.62万
依托单位：
FRED HUTCHINSON CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10636835
关键词：
BRCA1 gene BRCA2 gene Breast Breast Cancer Prevention Breast Cancer survivor Breast Cancer therapy Cancer Center Support Grant Catchment Area Center Core Grants Cessation of life Clinical Communities DNA DNA Repair Dedications Defect Derivation procedure Detection Diagnosis Direct Costs Disease ERBB2 gene Early Diagnosis Exercise Faculty Fostering Funding Genetic Predisposition to Disease Genetic Risk Grant Histologic Hormonal Incidence Institution Interdisciplinary Study Intervention Ionizing radiation Localized Malignant Neoplasm Malignant Neoplasms Malignant neoplasm of ovary Mammalian Oviducts Mismatch Repair Molecular Mutation Oncogenes Ovary PIK3CA gene Paper Peer Review Peritoneum Platinum Compounds Poly(ADP-ribose) Polymerase Inhibitor Population Predisposition Publishing Reproductive Behavior Research Research Personnel Research Project Grants Research Support Resistance Resource Sharing Resources Risk Risk Assessment Secondary to Serous Survivors Therapeutic Tissues Universities Washington Woman Work cancer care cancer prevention cancer type cognitive rehabilitation high risk homologous recombination hormone receptor-negative improved malignant breast neoplasm meetings member molecular subtypes mortality overexpression programs rare cancer recruit response stress reduction survivorship targeted treatment therapeutic target triple-negative invasive breast carcinoma

项目摘要

PROJECT SUMMARY: BREAST & OVARY CANCERS (BOC) The Breast & Ovary Cancers (BOC) Program brings together a highly cross-disciplinary and collaborative group of investigators dedicated to reducing the incidence and mortality of breast and ovary cancers. The program fosters interdisciplinary research at Fred Hutch (FH), University of Washington (UW), Seattle Cancer Care Alliance (SCCA), and in the community to improve cancer prevention, detection, diagnosis, and treatment. The BOC Program is led by Drs. Nancy Davidson and Elizabeth Swisher, along with Associate Program Leaders, Drs. Julie Gralow and Barbara Goff, who are leaders at the institutions described above. The Program aims to (1) improve strategies to assess risk, identify, screen, and prevent breast and ovary cancer in women, especially those at high risk and (2) develop targeted therapies for breast and ovary cancers with a special focus on improving response and predicting resistance. The BOC Program currently has 54 members with 11 based at Fred Hutch and 43 based at University of Washington. The current research support of BOC members is $14.7M (direct costs), of which $8.8M is peer- reviewed funding, including $3.5M from the NCI. BOC Program members published a total of 628 papers over the current grant period, of which 20% were intra-programmatic, 28% were inter-programmatic, and 47% had external co-authors. All 12 Consortium Shared Resources were utilized by BOC members in the course of their work. This P30 grant also assists this program by providing administrative and logistical support for BOC meetings, pilot funding for new research projects, and recruitment resources for new faculty.

项目摘要：乳腺癌和卵巢癌 (BOC) 乳腺癌和卵巢癌 (BOC) 项目汇集了高度跨学科和协作的团队致力于降低乳腺癌和卵巢癌的发病率和死亡率的研究小组。这项目促进 Fred Hutch (FH)、华盛顿大学 (UW)、西雅图癌症中心的跨学科研究护理联盟 (SCCA)，并在社区中改善癌症预防、检测、诊断和治疗治疗。 BOC 计划由博士领导。南希·戴维森 (Nancy Davidson) 和伊丽莎白·斯威舍 (Elizabeth Swisher) 以及同事项目负责人，博士。 Julie Gralow 和 Barbara Goff 是上述机构的领导者。该计划旨在 (1) 改进评估风险、识别、筛查和预防乳腺癌和卵巢癌的策略女性癌症，尤其是高危女性，以及 (2) 开发针对乳腺癌和卵巢癌的靶向疗法特别关注改善反应和预测阻力。 BOC 项目目前有 54 名成员，其中 11 名来自 Fred Hutch，43 名来自 University of University。华盛顿。目前 BOC 成员的研究支持为 1,470 万美元（直接成本），其中 880 万美元是同行费用审查了资金，包括来自 NCI 的 350 万美元。 BOC项目成员共发表论文628篇当前资助期，其中 20% 为计划内资助，28% 为计划间资助，47% 为计划间资助外部合著者。所有 12 个联盟共享资源均由 BOC 成员在其业务过程中使用工作。这笔 P30 赠款还通过为中国银行提供行政和后勤支持来协助该计划会议、新研究项目的试点资金以及新教师的招聘资源。