Research Program: Breast & Ovary Cancers

研究项目：乳房

• 批准号: 10636835
• 负责人: Cyrus M Ghajar
• 金额: $ 7.62万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10636835
• 关键词: BRCA1 gene; BRCA2 gene; Breast; Breast Cancer Prevention; Breast Cancer survivor; Breast Cancer therapy; Cancer Center Support Grant; Catchment Area; Center Core Grants; Cessation of life; Clinical; Communities; DNA; DNA Repair; Dedications; Defect; Derivation procedure; Detection; Diagnosis; Direct Costs; Disease; ERBB2 gene; Early Diagnosis; Exercise; Faculty; Fostering; Funding; Genetic Predisposition to Disease; Genetic Risk; Grant; Histologic; Hormonal; Incidence; Institution; Interdisciplinary Study; Intervention; Ionizing radiation; Localized Malignant Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Mammalian Oviducts; Mismatch Repair; Molecular; Mutation; Oncogenes; Ovary; PIK3CA gene; Paper; Peer Review; Peritoneum; Platinum Compounds; Poly(ADP-ribose) Polymerase Inhibitor; Population; Predisposition; Publishing; Reproductive Behavior; Research; Research Personnel; Research Project Grants; Research Support; Resistance; Resource Sharing; Resources; Risk; Risk Assessment; Secondary to; Serous; Survivors; Therapeutic; Tissues; Universities; Washington; Woman; Work; cancer care; cancer prevention; cancer type; cognitive rehabilitation; high risk; homologous recombination; hormone receptor-negative; improved; malignant breast neoplasm; meetings; member; molecular subtypes; mortality; overexpression; programs; rare cancer; recruit; response; stress reduction; survivorship; targeted treatment; therapeutic target; triple-negative invasive breast carcinoma

PROJECT SUMMARY: BREAST & OVARY CANCERS (BOC) The Breast & Ovary Cancers (BOC) Program brings together a highly cross-disciplinary and collaborative group of investigators dedicated to reducing the incidence and mortality of breast and ovary cancers. The program fosters interdisciplinary research at Fred Hutch (FH), University of Washington (UW), Seattle Cancer Care Alliance (SCCA), and in the community to improve cancer prevention, detection, diagnosis, and treatment. The BOC Program is led by Drs. Nancy Davidson and Elizabeth Swisher, along with Associate Program Leaders, Drs. Julie Gralow and Barbara Goff, who are leaders at the institutions described above. The Program aims to (1) improve strategies to assess risk, identify, screen, and prevent breast and ovary cancer in women, especially those at high risk and (2) develop targeted therapies for breast and ovary cancers with a special focus on improving response and predicting resistance. The BOC Program currently has 54 members with 11 based at Fred Hutch and 43 based at University of Washington. The current research support of BOC members is $14.7M (direct costs), of which $8.8M is peer- reviewed funding, including $3.5M from the NCI. BOC Program members published a total of 628 papers over the current grant period, of which 20% were intra-programmatic, 28% were inter-programmatic, and 47% had external co-authors. All 12 Consortium Shared Resources were utilized by BOC members in the course of their work. This P30 grant also assists this program by providing administrative and logistical support for BOC meetings, pilot funding for new research projects, and recruitment resources for new faculty.

项目摘要：乳腺癌和卵巢癌（BOC） 乳腺癌和卵巢癌（BOC）计划汇集了一个高度跨学科和协作的 一组研究人员致力于降低乳腺癌和卵巢癌的发病率和死亡率。这 计划在华盛顿大学（UW）的弗雷德·哈奇（FH）培养跨学科研究，西雅图癌症 护理联盟（SCCA），在社区中改善癌症预防，检测，诊断和 治疗。 BOC计划由Drs领导。南希·戴维森（Nancy Davidson）和伊丽莎白·斯威（Elizabeth Swisher）以及同事 计划负责人，博士。朱莉·格拉洛（Julie Gralow）和芭芭拉·高夫（Barbara Goff）是上述机构的领导人。 该计划旨在（1）改善评估风险，识别，筛查和预防乳房和卵巢的策略 女性的癌症，尤其是患有高风险的癌症，（2）开发针对乳腺癌和卵巢癌的靶向疗法 特别关注改善响应和预测阻力。 BOC计划目前有54名成员，其中11名位于弗雷德·哈奇（Fred Hutch），43位位于大学 华盛顿。 BOC成员的当前研究支持为1470万美元（直接费用），其中880万美元是同行 审查资金，包括NCI的350万美元。 BOC计划成员总共发表了628篇论文 当前的赠款期为20％，是截然期限的，28％是程序间的，有47％的 外部合着者。 BOC成员在其过程中使用了所有12个共享资源 工作。该P30赠款还通过为BOC提供行政和后勤支持来协助该计划 会议，新研究项目的试点资金以及新教师的招聘资源。