Molecular Analysis and Statistical Support Facility Core (MASS)

分子分析和统计支持设施核心 (MASS)

• 批准号: 10414005
• 负责人: Kun Lu
• 金额: $ 31.25万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414005
• 关键词: Address; Applications Grants; Area; Award; Bioinformatics; Biometry; Clinical; Communities; Competence; Conceptions; Consultations; Core Facility; Data; Data Analyses; Data Analytics; Data Collection; Data Science; Disease; Education and Outreach; Educational workshop; Ensure; Environmental Health; Faculty; Genomics; Grant; Health Sciences; Human Resources; Human Subject Research; Infrastructure; Interdisciplinary Study; Investigation; Laboratories; Lead; Medicine; Methods; Molecular; Molecular Analysis; North Carolina; Pathology; Pilot Projects; Predisposition; Public Health; Pulmonary Heart Disease; Research; Research Design; Research Methodology; Research Personnel; Sample Size; Science; Services; Statistical Methods; Technology; Training; Translating; Translational Research; Translations; Update; Work; analytical method; community engagement; data acquisition; data analysis pipeline; developmental disease; educational atmosphere; environment related cancer; improved; innovation; instrumentation; lectures; member; method development; novel; outreach; population based; programs; symposium; user-friendly

ABSTRACT The Molecular Analysis and Statistical Support (MASS) core supports the theme of the UNC Center for Environmental Health and Susceptibility (CEHS), translating interdisciplinary research on environmental health susceptibility to improve public health in North Carolina. The MASS will provide comprehensive, user-friendly, and efficient support for data acquisition, analysis, and interpretation needs of laboratory, clinical, and population-based investigations in environmental health. The MASS will provide access and facilitate utilization of a range of molecular cores and will integrate this support with rigorous and state-of-the-art biostatistics and bioinformatics assistance in study design, data acquisition, and data analysis to support translational research in the areas of Environmental Cancer, Cardiopulmonary Disease, and Developmental Disease (Aim 1). The MASS will develop and implement new molecular and statistical methods to meet investigators' analytic needs and to adapt to emerging data analysis strategies and unique data problems (Aim 2). The MASS will provide technical training, ranging from molecular methods to statistical, bioinformatics, and data science, for junior investigators through seminars, workshops, and symposia tailored to the needs of CEHS researchers (Aim 3). We collaborate with campus-wide efforts in genomics, exposure science, data science and computational medicine to expand the influence and expertise of CEHS investigators and junior investigators. Finally, the MASS subcores function collaboratively with the Integrated Health Sciences Facility Core (IHSFC) to support existing research, novel pilot projects, community engagement, and grant applications (Aim 4). Major program efforts and accomplishments during the past grant cycle include: updated infrastructure and instrumentation to enable CEHS investigators to access state-of-the-art analytical and molecular technologies; a new Method Development Award Program to support developing innovative new exposure science and molecular methods for CEHS investigators; and novel state-of-the-art data analysis pipelines for CEHS members. Faculty with expertise in molecular and quantitative methods development are available and serve as collaborators on pilot projects and external grants. Our MASS facility core provides a scalable, high quality, full service core facility to address data acquisition and analytic needs of our membership, from inception to implementation.

抽象的 分子分析和统计支持（MASS）核心支持UNC中心的主题 环境健康和易感性（CEHS），翻译有关环境的跨学科研究 改善北卡罗来纳州公共卫生的健康易感性。群众将提供全面的， 用户友好，有效的支持，以实验室，临床，临床，分析和解释需求 以及基于人群的环境健康调查。群众将提供访问和促进 利用一系列分子核，将将这种支持与严格和最先进的 研究设计，数据获取和数据分析方面的生物统计学和生物信息学协助以支持 环境癌，心肺疾病和发育领域的转化研究 疾病（目标1）。质量将开发和实施新的分子和统计方法来满足 研究者的分析需求并适应新兴的数据分析策略和独特的数据问题（目标 2）。群众将提供技术培训，从分子方法到统计，生物信息学和 数据科学，通过研讨会，研讨会和根据CEHS的需求量身定制的研讨会和研讨会 研究人员（目标3）。我们与校园范围内的基因组学，曝光科学，数据科学的努力以及 计算医学以扩大CEHS研究人员和初级研究人员的影响和专业知识。 最后，大量子核与集成健康科学机构核心（IHSFC）合作 为了支持现有研究，新颖的试点项目，社区参与和赠款应用程序（AIM 4）。主要的 在过去的赠款周期中的计划工作和成就包括：更新的基础架构和 仪器使CEHS研究人员能够访问最先进的分析和分子技术； 一个新的方法开发奖计划，以支持开发创新的新曝光科学和 CEHS研究人员的分子方法；以及CEHS的新型数据分析管道 成员。具有分子和定量方法开发方面具有专业知识的教师，并且可以作为 试点项目和外部赠款的合作者。我们的大众设施核心提供了可扩展，高质量，完整的 从成立到我们会员资格的数据获取和分析需求的服务核心设施，从成立到 执行。