Acquisition of Inductively Coupled Plasma Mass Spectrometry for Elemental Analysis

获取用于元素分析的电感耦合等离子体质谱仪

• 批准号: 10415598
• 负责人: Kun Lu
• 金额: $ 19.47万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415598
• 关键词: 14 year old; Biological Markers; Core Facility; Detection; Elements; Engineering; Equipment; Excision; Funding; Grant; Human Resources; Inductively Coupled Plasma Mass Spectrometry; Leadership; Mass Spectrum Analysis; Measurement; Metals; Minor; Modeling; Performance; Research; Research Personnel; Resources; Sampling; Services; Specialist; Technical Expertise; Time; United States National Institutes of Health; base; experience; instrumentation; research facility; success

PROJECT SUMMARY / ABSTRACT The S10 proposal seeks funding to purchase a new Agilent 8900 Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to replace our 14-year-old Agilent 7500 ICP-MS, which has been out of order since December 2020. The new ICP-MS will be housed in the Biomarker Mass Spectrometry Facility (BMSF), a shared UNC research facility that has successfully served the campus for over two decades. As an obsolete model, our 7500 ICP-MS was deemed unrepairable by Agilent service engineers. The 7500 ICP-MS, purchased with institutional funds in 2008, has been the workhorse equipment in the Facility and supported NIH grants totaling over $30 million in the last decade, demonstrating outstanding past performance of the ICP-MS at the BMSF to support funded research. The 7500 ICP-MS at the BMSF is the only shared ICP-MS resource on UNC campus. Unavailability of ICP-MS is very disruptive among our users and investigators, threatening the timely completion of active NIH-funded projects (~$18 million in next 5 years). Agilent ICP-MS remains best of its kind and Agilent 8900 ICP-MS has superb sensitivity and interference removal to enable the detection and quantitation of elements in diverse sample matrices with ultratrace levels of metals. The BMSF has great technical expertise in operating the ICP-MS, with a dedicated highly experienced research specialist. Dr. Lu, the Director of the BMSF, has over 15 years of experience in the mass spectrometry and metal analysis with ICP-MS, who has also established leadership in overseeing and managing research facilities/cores to support investigators in diverse fields. Selected 13 NIH-funded projects from 7 major (~76% AUT) and 3 minor users (~10% AUT), as outlined in this proposal, all have significant and urgent needs for state-of-the-art ICP-MS for sensitive elemental analysis. Our two decades of success has unequivocally established the BMSF as a key player in exposure measurement with ICP-MS. With everything in place at the BMSF, including unparalleled sensitive instrumentation, highly experienced personnel, a large user base, a strong leadership team and institutional commitment, the requested 8900 ICP-MS will continuously succeed as a valuable and unique resource to serve UNC and beyond.

项目摘要 /摘要 S10提案寻求资金购买新的Agilent 8900感应耦合等离子体质量 光谱法（ICP-MS）替换了我们14岁的Agilent 7500 ICP-MS，此后一直过失 2020年12月。新的ICP-MS将安置在生物标志物质谱设施（BMSF）中，该设施共享 UNC研究设施已成功为校园服务了二十年。作为一个过时的模型，我们 Agilent服务工程师认为7500 ICP-MS无法修复。使用的7500 ICP-MS 2008年的机构资金一直是该设施中的主力设备，并支持NIH赠款 在过去的十年中，超过3000万美元，证明了BMSF的ICP-MS过去表现出色 支持资助的研究。 BMSF的7500 ICP-MS是UNC校园上唯一共享的ICP-MS资源。 ICP-MS无法获得我们的用户和调查人员的破坏性，威胁到及时完成 活跃的NIH资助项目（未来5年内约1800万美元）。 Agilent ICP-MS仍然是同类和敏捷的最好的 8900 ICP-MS具有出色的灵敏度和干扰，以实现和定量 具有超级金属水平的不同样品矩阵中的元素。 BMSF具有良好的技术专业知识 经营ICP-MS，拥有一位专门的经验丰富的研究专家。 BMSF主任Lu博士， 拥有ICP-MS的质谱和金属分析经验超过15年 在监督和管理研究设施/核心方面建立了领导才能，以支持各种各样的研究者 字段。如概述 在此提案中，所有人都有对敏感元素分析的最新ICP-MS的巨大迫切需求。 我们的二十年成功已经确立了BMSF作为曝光度量的关键参与者 与ICP-MS。 BMSF的一切都到位，包括无与伦比的敏感仪器，高度 经验丰富的人员，大型用户群，强大的领导团队和机构承诺，要求 8900 ICP-MS将不断成功成为服务于UNC及以后的宝贵而独特的资源。