Molecular Analysis of Disease Pathways

疾病途径的分子分析

• 批准号: 10414315
• 负责人: Susan M Lunte
• 金额: $ 114.75万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414315
• 关键词: Basic Science; Biochemical; Biological; Biology; Biomedical Engineering; Biomedical Research; Centers of Research Excellence; Chemicals; Chemistry; Client; DNA Sequencing Facility; Development; Diagnosis; Disease; Disease Pathway; Environment; Faculty; Fees; Funding; Genomics; Goals; Grant; Health; Human; Infrastructure; Institution; Kansas; Laboratories; Mentors; Microfabrication; Microfluidics; Mission; Molecular Analysis; Molecular Biology; Pathway interactions; Phase; Pilot Projects; Positioning Attribute; Process; Request for Applications; Research; Research Personnel; Research Support; Science; Scientist; Services; Synthesis Chemistry; Technology; Universities; base; biomedical resource; career; faculty research; genome sequencing; member; nanofabrication; outreach; programs; recruit; senior faculty; success; voucher

PROJECT SUMMARY – OVERALL The COBRE CMADP was created in July 2012 to encourage basic research scientists to develop and implement new enabling technologies for the study of biological pathways and applied processes related to disease. Over the past nine years, CMADP investigators have pursued health-related research related to the molecular analysis of disease pathways. We have supported 24 junior faculty to date through research support and mentoring. The 18 faculty that have graduated from the program thus far have generated over $38.5 million in external funding. We also established three new Core Laboratories focused on enabling technologies for the study of disease: the Genome Sequencing Core, the Synthetic Chemical Biology Core and the KU Nanofabrication Facility (formerly the Microfabrication & Microfluidics Core). These three Cores brought new and essential enabling technologies to KU, allowing us to attract high-quality biomedical researchers and faculty to Kansas. As a result, CMADP strengthened both the human and the physical resources for biomedical research in the state. This application requests five years of funding for Phase 3 of our COBRE Center to pursue the following objectives: (1) to continue growing a critical mass of new and continuing investigators focused on the very broad theme of molecular analysis of disease pathways, (2) to continue a successful program of COBRE Pilot Project grants that utilize our Core Labs, and (3) to strengthen our existing Core Labs by expanding their capabilities and user bases, working with the KU Office of Research to position them for long-term sustainability based on a combination of fees generated plus a base of support from the University. The result will be a very strong cadre of successful mid-career biomedical research faculty and self-sustaining Core Labs that support research in molecular analysis of disease pathways statewide. We strongly believe that the overall impact of CMADP on biomedical research at KU and the state of Kansas will thus be substantial and enduring.

项目摘要 - 总体 CMADP成立于2012年7月，以鼓励基础研究科学家开发和实施 用于研究与疾病有关的生物学途径和应用过程的新促成技术。超过 过去的九年，CMADP调查人员进行了与分子分析有关的健康相关研究 疾病途径。我们已经通过研究支持和心理支持了24名初级教师。这 到目前为止，该计划毕业的18位教职员工创造了超过3850万美元的外部资金。 我们还建立了三个新的核心实验室，专注于促进疾病研究的技术： 基因组测序核心，合成化学生物学核心和KU纳米制作设施（以前 微加工和微流体核心）。这三个核心带来了新的和必不可少的能力技术 对KU，让我们能够吸引高质量的生物医学研究人员和教职员工来到堪萨斯州。结果，CMADP 加强了该州生物医学研究的人类和物理资源。此应用程序 要求我们的毛绒中心第3阶段的五年资金来追求以下目标：（1）继续 种植大量新的和持续的研究人员，专注于分子的广泛主题 疾病途径的分析，（2）继续成功的索伯飞行员项目赠款计划 我们的核心实验室和（3）通过扩大其功能和用户群来加强我们现有的核心实验室， 与KU研究办公室合作，将其定位为长期可持续性的基础 产生的饲料加上大学的支持基础。结果将是一个非常强大的成功干部 职业生物医学研究教师和自我维持的核心实验室，这些核心实验室支持分子分析中的研究 全州疾病途径。我们坚信，CMADP对生物医学研究的总体影响 因此，在KU和堪萨斯州将是实质性和持久的。