The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve Health

俄勒冈州立大学临床和转化科学中心：推进当今的发现以改善健康

• 批准号: 10474122
• 负责人: REBECCA D JACKSON
• 金额: $ 133.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-29 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474122
• 关键词: Address; Adopted; Adoption; Biomedical Research; Child Health; Childhood; Clinic; Clinical Sciences; Collaborations; Communities; Competence; Data; Data Analytics; Data Science; Development; Discipline; Education; Environment; Faculty; Foundations; Goals; Government; Grant; Health; Health system; Individual; Industry; Informatics; Information Dissemination; Institutes; Knowledge; Longevity; Methodology; Methods; Mission; Multi-Institutional Clinical Trial; Ohio; Participant; Pathway interactions; Patients; Pediatric Hospitals; Population; Process; Publications; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Resources; Role; Science; Scientist; Secure; System; Time; Training; Training Programs; Training Support; Training and Education; Translational Research; Translations; Universities; Vision; Work; Workforce Development; base; career; career development; clinical center; college; data sharing; data to knowledge; education resources; health inequalities; improved; innovation; member; novel strategies; programs; research study; skill acquisition; tool; translational approach; translational pipeline

PROJECT SUMMARY Ohio includes a very diverse population, with many minority, underserved, and vulnerable communities (MUVP). The need to increase testing in Ohio’s MUVP is great – testing rates are only at 2.0 per 1000, with positivity rates indicating active community spread. With rapidly rising infection rates, ways to curb infection and morbidity/mortality are needed, especially in the most vulnerable populations. This RADx-UP Initiative Large Network proposal, RADx-UP Ohio, leverages the vast community partnership networks of the Ohio Center for Clinical and Translational Science Award and the OSU Comprehensive Cancer Center to identify reasons for and intervene to reduce disparities in COVID-19 education, testing, contact tracing, follow-up and treatment among MUVP in Ohio in a bi-directional academic-state-community partnership. This complements the work of Ohio Department of Health (ODH) emergency response to this pandemic. Our research process is guided by a socio-ecological model based on the Social Determinants of Health, the Proctor Model for Implementation Science2 and a Community-Based Participatory Research (CBPR) framework and prior preliminary work of the team, using an implementation science framework and overall program evaluation. The specific aims are to: Aim 1. Implement a multi-level intervention, built on effective interventions of the team, to increase the impact of COVID testing in MUVP in 12 selected counties informed by community partner input that will increase uptake of COVID-19 testing, knowledge of COVID-19 testing and results, and follow-up including contact tracing for positives. Aim 2. Assess the impact and sustainability of the intervention in different MUVP in Ohio. Aim 3. Interact with public health entities to disseminate successful strategies. The interventions will be culturally- appropriate and tailored to the needs of each MUVP in the 12 selected counties using an implementation science design, with counties randomized in a 3-wave step wedge design. RADx-Up Ohio includes the following Units: Community Engagement and Intervention; Testing; Statistics and Data Management); Human Subjects, and Evaluation. RADx-UP Ohio uses a hub and spoke model where the units provide expertise to support the activities of the 4 regional teams, each of which includes CHWs from each of the 3 individual counties with at least one community stakeholder to provide community context and ensure authentic partnerships are maintained. We will work closely with the RADx-UP Imitative components to successfully complete the aims.

项目摘要 俄亥俄州的人口非常多样，有许多少数，服务不足和弱势社区（MUVP）。 在俄亥俄州的MUVP中增加测试的需求很棒 - 测试率为每1000，率为2.0，为正率 表明积极的社区传播。感染率迅速上升，遏制感染的方法和 需要发病/死亡率，尤其是在最脆弱的人群中。这项RADX-UP计划很大 网络提案，俄亥俄州拉德克斯 - 俄亥俄州，利用俄亥俄州庞大的社区伙伴关系网络 临床和转化科学奖和OSU综合癌症中心，以确定原因 并干预以减少19日教育，测试，联系跟踪，随访和治疗的分布 在俄亥俄州的MUVP中，在双向学术国家社区伙伴关系中。这完成了 俄亥俄州卫生部（ODH）对这一大流行的紧急回应。我们的研究过程由 社会生态模型基于健康的社会决定因素，即实施的监理模型 Science2和基于社区的参与性研究（CBPR）框架和先前的初步工作 团队，使用实施科学框架和整体计划评估。具体目的是：目标 1。实施基于团队有效干预的多层次干预措施，以增加 MUVP中的COVID测试在12个选定的计数中由社区伙伴输入告知，这将增加吸收 COVID-19测试，COVID-19测试的知识和结果以及随访，包括接触跟踪 积极的。目标2。评估俄亥俄州不同MUVP干预措施的影响和可持续性。目标3。 与公共卫生实体互动以传播成功的策略。干预措施将是文化的 - 使用实施科学在12个选定县的每个MUVP的需求适当和量身定制 设计，县在3波步骤楔形设计中随机分组。 RADX-UP俄亥俄州包括以下单元： 社区参与和干预；测试；统计和数据管理）；人类主题，和 评估。 Radx-Up Ohio使用轮毂和辐条模型，单位提供专业知识来支持 四个区域团队的活动，每个团队都包括来自3个单个县每个县的CHW 至少有一个社区利益相关者提供社区环境并确保真实的伙伴关系是 维护。我们将与RADX-UP模拟组件紧密合作，以成功完成目标。