Egocentric and Allocentric Spatial Coding in Cortex

皮质中的自我中心和异中心空间编码

• 批准号: 10471228
• 负责人: Michael E Hasselmo
• 金额: $ 50.14万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-20 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10471228
• 关键词: Address; Applications Grants; Behavior; Brain; Cells; Code; Cognition; Cognitive; Cues; Darkness; Data; Dimensions; Drops; Environment; Generations; Goals; Grant; Head; Impairment; Individual; Laboratories; Light; Link; Location; Medial; Mental disorders; Modeling; Motion; Nature; Neurons; Pattern; Play; Population; Positioning Attribute; Property; Rattus; Rewards; Role; Running; Sensory; Shapes; Slice; Speed; Structure; Testing; Theta Rhythm; Time; Visual; awake; cognitive function; entorhinal cortex; experimental study; nervous system disorder; neurophysiology; novel; optogenetics; predictive modeling; relating to nervous system; response; sensory input; way finding

PROJECT SUMMARY/ABSTRACT The projects proposed in this new grant address the properties of spatial coding in cortical regions. Representations of spatial location are important for a broad range of cognitive functions, including the planning of goal-directed navigation. This grant proposes specific experiments to test modeling predictions about the existence of egocentric representations of boundaries and coding of running speed relevant to the formation of allocentric spatial representations in cortical structures. Specific Aim #1: Recordings of the neural spiking activity in retrosplenial cortex and entorhinal cortex will test the hypothesis that cortical regions must code the position of environmental boundaries in egocentric coordinates. This prediction arose from models of the formation of allocentric representations of boundaries which require input from an egocentric, view-centered coding of environmental boundaries. Experiments will extend preliminary data from this lab showing egocentric coding of boundaries in retrosplenial cortex. Models show that egocentric boundary cells could be combined with head direction input to code allocentric boundary position, which can drive coding of spatial location. Further experiments will test the influence of environmental boundaries on spiking activity in the entorhinal cortex and retrospenial cortex, including testing the influence of manipulations of the shape of the environment, the insertion of new boundaries and different reward locations, recordings in darkness, and testing coexistence of egocentric coding with allocentric coding by head direction cells. This experimental testing of the predictions from models will provide an important link for building our understanding of the coding of space for cognitive processing. Specific Aim #2: Recordings of neural spiking activity in retrosplenial cortex and entorhinal cortex will test the complementary hypothesis that coding of running speed also plays a role in generation of representations of spatial location, and how the coding of running speed varies over different time courses and may depend on sensory input from boundaries. Experiments will include analysis of the coding of running speed at different spatial scales in entorhinal cortex and retrosplenial cortex ranging from one second to many minutes. The time course will also be analyzed in experiments exploring the change in running speed representations when barrier features are obscured by darkness. This aim also includes whole cell patch recording in slices to analyze the time course of intrinsic spiking activity relevant to the circuit dynamics for coding of speed and location. Finally, optogenetic inactivation of specific populations of neurons in medial septum will test how inputs regulate the coding of spatial location and speed by neurons in the medial entorhinal cortex. These experiments will contribute to our understanding of the dynamics of cortical circuits that underlie the formation of allocentric spatial representations important to many aspects of cortical cognitive processing, including the planning of goal-directed behavior.

项目摘要/摘要 在这项新赠款中提出的项目介绍了皮质区域空间编码的属性。 空间位置的表示对于广泛的认知功能很重要，包括 计划导向导航。该赠款提出了特定的实验来测试建模预测 关于边界的以自负为中心表示和与 在皮质结构中形成同类空间表示。 特定目的＃1：腹膜后皮质和内嗅皮层中神经尖峰活动的记录将测试 皮层区域必须在以自我为中心的环境边界的位置进行编码的假设 坐标。该预测来自边界同类形成的模型 这需要从以自我为中心的，以视图为中心的环境边界编码的输入。实验会 从该实验室扩展了初步数据，显示了腹膜后皮层中边界的自我中心编码。型号 表明以自我为中心的边界细胞可以与头方向输入到代码中心边界相结合 位置，可以推动空间位置的编码。进一步的实验将测试环境的影响 内嗅皮质和递质皮层中峰值活动的边界，包括测试的影响 操纵环境形状，插入新边界和不同的奖励位置， 在黑暗中记录和测试以同类编码为中心编码的自我编码的共存 细胞。对来自模型预测的预测的实验测试将为建立我们的重要链接 了解认知处理空间的编码。 具体目的＃2：腹膜后皮质和内嗅皮层中神经尖峰活动的记录将测试 互补的假设，即跑步速度的编码也在产生的代表中起作用 空间位置以及运行速度的编码如何在不同的时间课程中变化，并且可能取决于 来自边界的感觉输入。实验将包括对不同的运行速度编码的分析 内嗅皮层中的空间尺度和脾后皮质的范围从一秒钟到很多分钟。时间 当课程还将在实验中进行分析，以探讨运行速度表示的变化 障碍特征被黑暗掩盖。此目的还包括切片中的整个单元格录制到 分析与电路动力学相关的固有尖峰活动的时间过程，以编码速度和 地点。最后，内侧隔膜中特定神经元特定群体的光学遗传灭活将测试如何 输入调节内侧内侧皮层中神经元的空间位置和速度的编码。这些 实验将有助于我们理解构成基础的皮质电路动力学 对于皮质认知处理的许多方面重要的同种形式空间表示，包括 计划指导行为。